Vacuolar-type H+-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 24, 2002, Pages 3525-3528

  Yoshimoto, Yuya ^a   Jyojima, Takaaki ^a   Arita, Tsuyoshi ^a   Ueda, Minoru ^a   Imoto, Masaya ^a   Matsumura, Shuichi ^a   Toshima, Kazunobu ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAL DERIVATIVE; ADENOSINE TRIPHOSPHATASE; EPIDERMAL GROWTH FACTOR RECEPTOR; HYDROXYL GROUP; KANAMYCIN DERIVATIVE; LACTONE DERIVATIVE; ANTIINFECTIVE AGENT; CONCANAMYCIN F; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR; MACROLIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; TUMOR PROTEIN;

ACIDIFICATION; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; PH; PHYSIOLOGY;

ANTI-BACTERIAL AGENTS; APOPTOSIS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; MACROLIDES; NEOPLASM PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 0036889972     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00806-5     Document Type: Article

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