Endothelial cells maintain a reduced redox environment even as mitochondrial function declines

American Journal of Physiology - Cell Physiology

Volumn 283, Issue 6 52-6, 2002, Pages

  Carlisle, Ricarda ^a   Rhoads, Carol Ann ^a   Aw, Tak Yee ^a   Harrison, Lynn ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Cell size changes; Genomic instability; Glutathione; Human umbilical vein endothelial cells; Replicative senescence

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL DIVISION; CELL NUCLEUS; CELL SIZE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MITOCHONDRION; OXIDATION REDUCTION POTENTIAL; OXYGEN CONSUMPTION; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

EID: 0036889021     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00092.2002     Document Type: Article

References (53)

1. Allen RG, Tresini M, Keogh BP, Doggett DL, and Cristofalo VJ. Differences in electron transport potential, antioxidant defenses, and oxidant generation in young and senescent fetal lung fibroblasts (WI-38). J Cell Physiol 180: 114-122, 1999.
2. Alvarez E, Ruiz-Gutierrez V, Sobrino F, and Santa-Maria C. Age-related changes in membrane lipid composition, fluidity and respiratory burst in rat peritoneal neutrophils. Clin Exp Immunol 124: 95-102, 2001.
3. Aw TY. Cellular and molecular responses to oxidative stress and redox imbalance. Am J Clin Nutr 70: 557-565, 1999.
4. Bandy B and Davison AJ. Mitochondrial mutations increase oxidative stress: Implications for carcinogenesis and aging? Free Radic Biol Med 8: 523-539, 1990.
5. Barazzoni R, Short KR, and Nair KS. Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart. J Biol Chem 275: 3343-3347, 2000.
6. Barnett YA and King CM. An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans. Mutat Res 338: 115-128, 1995.
7. Berlett BS and Stadtman ER. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 272: 20313-20316, 1997.
8. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
9. Bürrig KF. The endothelium of advanced arteriosclerotic plaques in humans. Arterioscler Thromb 11: 1678-1689, 1991.
10. Chang E and Harley CB. Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci USA 92: 11190-11194, 1995.
11. Chen JC, Warshaw JB, and Sanadi DR. Regulation of mitochondrial respiration in senescence. J Cell Physiol 80: 141-148, 1972.
12. Chen KH, Reece LM, and Leary JF. Mitochondrial glutathione modulates TNF-α-induced endothelial cell dysfunction. Free Radic Biol Med 27: 100-109, 1999.
13. Cortopassi GA and Arnheim N. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res 18: 6927-6933, 1990.
14. Cottrell DA, Blakely EL, Borthwick GM, Johnson MA, Taylor GA, Brierley EJ, Ince PG, and Turnball DM. Roles of mitochondrial DNA mutations in disease and aging. Ann NY Acad Sci 908: 199-207, 2000.
15. Cristofalo VJ. Metabolic aspects of aging in diploid human cells. In: Aging in Cell and Tissue Culture, edited by Holeckovà E and Cristofalo VJ. New York: Plenum, 1970, p. 83-119.
16. Deutsch J. Glucose-6 phosphate dehydrogenase. Methods Enzymol 3: 190-196, 1983.
17. Dimiri GP, Lee X, Basile G, Acosta M, Scott G, Roskeley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacocke M, and Campisi J. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367, 1995.
18. Fenton M, Barker S, Kurz DJ, and Erusalimsky JD. Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries. Arterioscler Thromb Vasc Biol 21: 220-226, 2001.
19. Finkel T and Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 408: 239-247, 2000.
20. Goldberg DM and Spooner RJ. Glutathione reductase. Methods Enzymol 3: 258-264, 1983.
21. Goldstein S, Ballantyne SR, Robson AL, and Moerman EJ. Energy metabolism in cultured human fibroblasts during aging in vitro. J Cell Physiol 112: 419-424, 1982.
22. van Gorp RMA, Hornstra G, van Dam-Mieras MCE, and Heemskerk JWM. Function of glutathione peroxidase in endothelial cell vitality. Arch Biochem Biophys 382: 63-71, 2000.
23. Grillari J, Hohenwarter O, Grabherr RM, and Katinger H. Subtractive hybridization of mRNA from early passage and senescent endothelial cells. Exp Gerontol 35: 187-197, 2000.
24. Hamilton ML, Van Remmen H, Drake JA, Yang H, Guo ZM, Kewitt K, Walter CA, and Richardson A. Does oxidative damage to DNA increase with age? Proc Natl Acad Sci USA 98: 10469-10474, 2000.
25. Harper ME, Monemdjou S, Ramsey JJ, and Weindruch R. Age-related increase in mitochondrial proton leak and decrease in ATP turnover reactions in mouse hepatocytes. Am J Physiol Endocrinol Metab 275: E197-E206, 1998.
26. Ho HY, Cheng ML, Lu FJ, Chou YH, Stern A, Liang CM, and Chiu DTS. Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. Free Radic Biol Med 29: 156-169, 2000.
27. Hu HL, Forsey RJ, Blades TJ, Barratt MEJ, Parmar P, and Powell JR. Antioxidants may contribute in the fight against ageing: An in vitro model. Mech Ageing Dev 121: 217-230, 2000.
28. Jones DP. Determination of pyridine dinucleotides in cell extracts by high-performance liquid chromatography. J Chromatogr 225: 446-449, 1981.
29. Jones DP and Mason HS. Apparatus for automatically maintaining cell suspension at low oxygen concentrations: The oxystat. Anal Biochem 90: 155-166, 1978.
30. Kumazaki T. Modulation of gene expression during aging of human vascular endothelial cells. Hiroshima J Med Sci 42: 97-100, 1993.
31. Lakatta EG. Cardiovascular regulatory mechanisms in advanced age. Physiol Rev 73: 413-467, 1993.
32. Lawler JM and Demaree SR. Relationship between NADP-specific isocitrate dehydrogenase glutathione peroxidase in aging skeletal muscle. Mech Ageing Dev 122: 291-304, 2001.
33. Lerman A, Edwards BS, Hallett JW, Heublein DM, Sandberg SM, and Burnett JC. Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. N Engl J Med 325: 997-1001, 1991.
34. Lima L, Malaise E, and Macieira-Coelho A. Aging in vitro effect of low dose rate irradiation on the division potential of chick embryonic fibroblasts. Exp Cell Res 73: 345-350, 1972.
35. Maier JAM, Statuto M, and Ragnotti G. Senescence stimulates U937-endothelial cell interactions. Exp Cell Res 208: 270-274, 1993.
36. Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, and Attardi G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 286: 774-779, 1999.
37. Miquel J, Ferrándiz ML, De Juan E, Sevila I, and Martinez M. N-Acetylcysteine protects against age-related decline of oxidative phosphorylation in liver mitochondria. Eur J Pharmacol 292: 333-335, 1995.
38. Noy N, Schwartz H, and Gafni A. Age-related changes in the redox status of rat muscle cells and their role in enzyme-aging. Mech Ageing Dev 29: 63-69, 1985.
39. Oh CW, Bump EA, Kim JS, Janigro D, and Mayberg MR. Induction of a senescence-like phenotype in bovine aortic endothelial cells by ionizing radiation. Radiat Res 156: 232-240, 2001.
40. Orr WC and Sohal RS. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263: 1128-1130, 1994.
41. Overbergh L, Valckx D, Waer M, and Mathieu C. Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine 11: 305-312, 1999.
42. Poston RN, Haskard DO, Coucher JR, Gall NP, and John. son-Tiedy RR. Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am J Pathol 140: 665-673, 1992.
43. Rajamanickam C, Merten S, Kwiatkowska-Patzer B, Chuang C, Zak R, and Rabinowitz M. Changes in mitochondrial DNA in cardiac hypertrophy in the rat. Circ Res 45: 505-515, 1979.
44. Reed DJ, Babson JR, Beatty PW, Brodie AE, Ellis WW, and Potter DW. High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Anal Biochem 106: 55-62, 1980.
45. Rikans LE and Hornbrook KR. Lipid peroxidation, antioxidant protection and aging. Biochim Biophys Acta 1362: 116-127, 1997.
46. Sanz N, Diez-Fernández C, Alvarez A, and Cascales M. Age-dependent modifications in rat hepatocyte antioxidant defense systems. J Hepatol 27: 525-534, 1997.
47. Shigenaga MK, Hagen TM, and Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci USA 91: 10771-10778 1994.
48. Sohal RS and Weindruch R. Oxidative stress, caloric restriction, and aging. Science 273: 59-63, 1996.
49. Tappel AL. Glutathione peroxidase and hydroperoxides. Methods Enzymol 52: 506-513, 1978.
50. Tokunaga O, Fan J, and Watanabe T. Atherosclerosis- and age-related multinucleated variant endothelial cells in primary culture from human aorta. Am J Pathol 135: 967-976, 1989.
51. Wilson PD and Franks LM. The effect of age on mitochondrial ultrastructure and enzymes. Adv Exp Med Biol 53: 171-183, 1975.
52. Xu D, Neville R, and Finkel T. Homocysteine accelerates endothelial cell senescence. FEBS Lett 470: 20-24, 2000.
53. Yoshida N, Granger DN, Anderson DC, Rothlein R, Lane C, and Kvietys PR. Anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells. Am J Physiol Heart Circ Physiol 262: H1891-H1898, 1992.