Mechanical environment, donor age, and presence of endothelium interact to modulate porcine artery viability ex vivo

Annals of Biomedical Engineering

Volumn 30, Issue 9, 2002, Pages 1117-1127

  Clerin, V ^a   Gusic, R J ^a   O'Brien, J ^b   Kirshbom, P M ^b   Myung, R J ^b   Gaynor, J W ^b   Gooch, Keith J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Carotid artery; Mechanical effects; Organ culture; Tissue engineering

Indexed keywords

BIOLOGICAL ORGANS; BIOMEDICAL ENGINEERING; HISTOLOGY; IMMUNOLOGY; LAMINAR FLOW; STATISTICAL METHODS; TISSUE CULTURE;

ARTERIES;

BLOOD VESSELS;

AGE; ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOMECHANICS; CAROTID ARTERY; HEMODYNAMICS; HISTOLOGY; IN VITRO STUDY; INSTRUMENTATION; NEWBORN; ORGAN CULTURE TECHNIQUE; ORGAN PRESERVATION; PERFUSION; PHYSIOLOGY; SWINE; TISSUE ENGINEERING; VASCULAR ENDOTHELIUM;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BIOMECHANICS; CAROTID ARTERIES; ENDOTHELIUM, VASCULAR; HEMODYNAMIC PROCESSES; MODELS, CARDIOVASCULAR; ORGAN CULTURE TECHNIQUES; ORGAN PRESERVATION; PERFUSION; SUS SCROFA; TISSUE ENGINEERING;

EID: 0036882371     PISSN: 00906964     EISSN: None     Source Type: Journal    
DOI: 10.1114/1.1519262     Document Type: Article

References (35)

1. Bardy, N., G.J. Karillon, R. Merval, J.L. Samuel, and A. Tedgui. Differential effects of pressure and flow on DNA and protein synthesis and on fibronectin expression by arteries in a novel organ culture system. Circ. Res. 77:684-694, 1995.
2. Bardy, N., R. Merval, J. Benessiano, J.L. Samuel, and A. Tedgui. Pressure and angiotensin II synergistically induce aortic fibronectin expression in organ culture model of rabbit aorta. Evidence for a pressure-induced tissue reninangiotensin system. Circ. Res. 79:70-78, 1996.
3. Birukov, K.G., S. Lehoux, A.A. Birukova, R. Merval, V.A. Tkachuk, and A. Tedgui. Increased pressure induces sustained protein kinase C-independent herbimycin A-sensitive activation of extracellular signal-related kinase 1/2 in the rabbit aorta in organ culture. Circ. Res. 81:895-903, 1997.
4. Brownlee, R.D., and B.L. Langille. Arterial adaptations to altered blood flow. Can. J. Physiol. Pharmacol. 69:978-983, 1991.
5. Chesler, N.C., B.S. Conklin, H.C. Han, and D.N. Ku. Simplified ex vivo artery culture techniques for porcine arteries. J. Vasc. Investigations 4:123-127, 1998.
6. Chesler, N.C., D.N. Ku, and Z.S. Galis. Transmural pressure induces matrix-degrading activity in porcine arteries ex vivo. Am. J. Physiol. 277:H2002-H2009, 1999.
7. Cho, A., L. Mitchell, D. Koopmans, and B.L. Langille. Effects of changes in blood flow rate on cell death and cell proliferation in carotid arteries of immature rabbits. Circ. Res. 81:328-337, 1997.
8. Clerin, V., J.W. Nichol, M. Petko, R.J. Myung, J.W. Gaynor, and K.J. Gooch. Tissue engineering of arteries by directed remodeling of intact arterial segments. Tiss. Eng. (in press).
9. Gooch, K.J., and C.J. Tennant, Mechanical Forces: Their Effects on Cells and Tissues. Berlin: Springer, 1997, p. 182.
10. Han, H.C., and D.N. Ku. Contractile responses in arteries subjected to hypertensive pressure in seven-day organ culture. Ann. Biomed. Eng. 29:467-475, 2001.
11. Herman, I.M., A.M. Brant, V.S. Warty, J. Bonaccorso, E.C. Klein, R.L. Kormos, and H.S. Borovetz. Hemodynamics and the vascular endothelial cytoskeleton. J. Cell Biol. 105:291-302, 1987.
12. Labadie, R.F., J.F. Antaki, J.L. Williams, S. Katyal, J. Ligush, S.C. Watkins, S.M. Pham, and H.S. Borovetz. Pulsatile perfusion system for ex vivo investigation of biochemical pathways in intact vascular tissue. Am. J. Physiol. 270:H760-H768, 1996.
13. Langille, B.L., M.P. Bendeck, and F.W. Keeley. Adaptations of carotid arteries of young and mature rabbits to reduced carotid blood flow. Am. J. Physiol. 256:H931-H939, 1989.
14. L'Heureux, N., L. Germain, R. Labbe, and F.A. Auger. In vitro construction of a human blood vessel from cultured vascular cells: A morphologic study. J. Vasc. Surg. 17:499-509, 1993.
15. L'Heureux, N., S. Paquet, R. Labbe, L. Germain, and F.A. Auger. A completely biological tissue-engineered human blood vessel. FASEB J. 12:47-56, 1998.
16. Liu, S.Q. Biomechanical basis of vascular tissue engineering. Crit. Rev. Biomed. Eng. 27:75-148, 1999.
17. Masood, L., K.E. Porter, and N.J. London. Endothelin-1 is a mediator of intimal hyperplasia in organ culture of human saphenous vein. Br. J. Surg. 84:499-503, 1997.
18. Miyashiro, J.K., V. Poppa, and B.C. Berk. Flow-induced vascular remodeling in the rat carotid artery diminishes with age. Circ. Res. 81:311-319, 1997.
19. Mount, L.E., and D.L. Ingram. The Pig as a Laboratory Animal. New York: Academic, 1971.
20. Nguyen, K., R. Schmedlen, and J.L. West. Culture of engineered vascular grafts under flow stimulated extracellular matrix synthesis. Ann. Biomed. Eng. 29:S-146, 2001.
21. Niklason, L.E., W. Abbott, J. Gao, B. Klagges, K.K. Hirschi, K. Ulubayram, N. Conroy, R. Jones, A. Vasanawala, S. Sanzgiri, and R. Langer. Morphologic and mechanical characteristics of engineered bovine arteries. J. Vasc. Surg. 33:628-638, 2001.
22. Niklason, L.E., J. Gao, W.M. Abbott, K.K. Hirschi, S. Houser, R. Marini, and R. Langer. Functional arteries grown in vitro. Science 284:489-493, 1999.
23. Porter, K.E., S. Nydahl, P. Dunlop, K. Varty, A.J. Thrush, and N.J. London. The development of an in vitro flow model of human saphenous vein graft intimal hyperplasia. Cardiovasc. Res. 31:607-614, 1996.
24. Porter, K.E., D.H. Olojugba, I. Masood, M. Pemberton, P.R. Bell, and N.J. London. Endothelin-B receptors mediate intimal hyperplasia in an organ culture of human saphenous vein. J. Vasc. Surg. 28:695-701, 1998.
25. Qiu, Y., and J.M. Tarbell. Interaction between wall shear stress and circumferential strain affects endothelial cell biochemical production. J. Vasc. Res. 37:147-157, 2000.
26. Recchia, F.A., B.J. Byrne, and D.A. Kass. Sustained vessel dilation induced by increased pulsatile perfusion of porcine carotid arteries in vitro. Acta Physiol. Scand. 166:15-21, 1999.
27. Seliktar, D., R.A. Black, R.P. Vito, and R.M. Nerem. Dynamic mechanical conditioning of collagen-gel blood vessel constructs induces remodeling in vitro. Ann. Biomed. Eng. 28:351-362, 2000.
28. Shinoka, T., D. Shum-Tim, P.X. Ma, R.E. Tanel, N. Isogai, R. Langer, J.P. Vacanti, and J.E. Mayer, Jr. Creation of viable pulmonary artery autografts through tissue engineering. J. Thorac. Cardiovasc. Surg. 115:536-545, discussion 545-546, 1998.
29. Soyombo, A.A., G.D. Angelini, A.J. Bryan, and A.C. Newby. Surgical preparation induces injury and promotes smooth muscle cell proliferation in a culture of human saphenous vein. Cardiovasc. Res. 27:1961-1967, 1993.
30. Tranquillo, R.T., T.S. Girton, B.A. Bromberek, T.G. Triebes, and D.L. Mooradian. Magnetically orientated tissue-equivalent tubes: Application to a cicumferentially orientated media-equivalent. Biomaterials 17:349-357, 1996.
31. Vorp, D.A., D.G. Peters, and M.W. Webster. Gene expression is altered in perfused arterial segments exposed to cyclic flexure ex vivo. Ann. Biomed. Eng. 27:366-371, 1999.
32. Vyalov, S., B.L. Langille, and A.L. Gotlieb. Decreased blood flow rate disrupts endothelial repair in vivo. Am. J. Pathol. 149:2107-2118, 1996.
33. Wechezak, A.R., D.E. Coan, R.F. Viggers, and L.R. Sauvage. Dextran increases survival of subconfluent endothelial cells exposed to shear stress. Am. J. Physiol. 264:H520-H525, 1993.
34. Weinberg, C., and E. Bell. Blood vessel model constructed from collagen and cultured vascular cells. Science 231:397-400, 1986.
35. Ziegler, T., and R.M. Nerem. Tissue engineering a blood vessel: Regulation of vascular biology by mechanical stresses. J. Cell. Biochem. 56:204-209, 1994.