Reduction of plasma homocystein by folic acid in children with chronic renal failure

Pediatric Nephrology

Volumn 17, Issue 7, 2002, Pages 511-514

  Kang, Hee Gyung ^a   Lee, Byong Sop ^a   Hahn, Hyewon ^a   Lee, Jun Ho ^a   Ha, Il Soo ^a   Cheong, Hae Il ^a   Choi, Yong ^a,b  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Chronic renal failure; Folic acid; Homocysteine; Predialysis

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID DERIVATIVE; HOMOCYSTEINE; ANTIANEMIC AGENT; FOLIC ACID;

ADOLESCENT; AMINO ACID BLOOD LEVEL; ARTICLE; CARDIOVASCULAR DISEASE; CHILD; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE COURSE; FEMALE; HEMODIALYSIS; HUMAN; HYPERHOMOCYSTEINEMIA; KIDNEY TRANSPLANTATION; MALE; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; VITAMIN SUPPLEMENTATION; BLOOD; CLINICAL TRIAL; INFANT; PRESCHOOL CHILD;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; FOLIC ACID; HEMATINICS; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; INFANT; KIDNEY FAILURE, CHRONIC; MALE;

EID: 0036882283     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-002-0864-8     Document Type: Article

References (28)

1. Wilcken DE (1998) Novel risk factors for vascular disease: the homocysteine hypothesis of cardiovascular disease. J Cardiovasc Risk 5:217-221
2. Jungers P, Chauveau P, Bandin O, Chadefaux B, Aupetit J, Labrunie M, Descamps-Latscha B, Kamoun P (1997) Hyperhomocysteinemia is associated with atherosclerotic occlusive arterial accidents in predialysis chronic renal failure patients. Miner Electrolyte Metab 23:170-173
3. Jungers P, Joly D, Massy Z, Chauveau P, Nguyen AT, Aupetit J, Chadefaux B (1999) Sustained reduction of hyperhomocysteinemia with folic acid supplementation in predialysis patients. Nephrol Dial Transplant 14:2903-2906
4. Thambyrajah J, Landray MJ, McGlynn FJ, Jones HJ, Wheeler DC, Townend JN (2000) Does folic acid decrease plasma homocysteine and improve endothelial function in patients with predialysis renal failure? Circulation 102:871-875
5. Wilcken DE, Dudman NP, Tyrrell PA, Robertson MR (1988) Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: possible implication for prevention of vascular disease. Metabolism 37:697-701
6. Chauveau P, Chadefaux B, Coude M, Aupetit J, Kamoun P, Jungers P (1996) Long-term folic acid (but not pyridoxine) supplementation lowers elevated plasma homocysteine level. Miner Electrolyte Meta 22:106-109
7. Vilaseca MA, Moyano D, Artuch R, Ferrer I, Pineda M, Cardo E, Campistol J, Pavia C, Camacho JA (1998) Selective screening for hyperhomocysteinemia in pediatric patients. Clin Chem 44:662-663
8. Lilien M, Duran M, Hoeck K van, Poll-The BT, Schröder C (1999) Hyperhomocyst(e)inaemia in children with chronic renal failure. Nephrol Dial Transplant 14:366-368
9. Merouani A, Lamber M, Delvin EE, Genest JJ, Robitaille P, Rozen R (2001) Plasma homocysteine concentration in children with chronic renal failure. Pediatr Nephrol 16:805-811
10. Schwartz GJ, Brion LP, Spitzer A (1987) The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children and adolescents. Pediatr Clin North Am 34:571-590
11. Behrman RE, Kliegman RM, Jenson HB (2000) Textbook of pediatrics, 16th edn. Saunders, Philadelphia, p 2195
12. Refsum H, Ueland PM, Svardal AM (1989) Fully automated fluorescence assay for determining total homocysteine in plasma. Clin Chem 35:1921-1927
13. Vilaseca MA, Moyano D, Ferrer I, Artuch R (1997) Total homocysteine in pediatric patients. Clin Chem 43:690-692
14. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH (1993) Vitamin status and intake as primary determinants of homocysteine in an elderly population. JAMA 270:2693-2698
15. Moustapha A, Naso A, Nahlawi M, Gupta A, Arheart KL, Jacobsen DW, Robinson K, Dennis VW (1998) Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease. Circulation 97:138-141
16. Soria C, Chadefaux B, Coudé M, Gaillard O, Kamoun P (1990) Concentrations of total homocysteine in plasma in chronic renal failure. Clin Chem 36:2137-2138
17. Arnadottir M, Hutberg B, Nilsson-Ehle P, Thysell H (1996) The effect of reduced glomerular filtration rate on plasma total homocysteine concentration. Scand J Clin Lab Invest 56: 41-46
18. Bostom AG, Shemin D, Lapane KL, Hume AL, Yoburn D, Nadeau MR, Bendich A, Selhub J, Rosenberg IH (1996) High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients. Kidney Int 49:147-152
19. Crawford JF, Rosenthal AF, Spears C, Tabari H (2001) Normalization of homocysteine in dialysis patients by directed repletion, with apparent reduction of access thrombosis. Dial Transplant 30:512-521
20. Sunder-Plassmann G, Födinger M, Buchmayer G, Papagiannopoulos M, Wojcik J, Kletzmayr J, Enzenberger B, Janata O, Winkelmayer WC, Paul G, Auinger M, Barnas U, Hörl WH (2000) Effect of high dose folic acid therapy on hyperhomocysteinemia in hemodialysis patients: results of the Vienna multicenter study. J Am Soc Nephrol 11:1106-1116
21. Schröder CH, Boer AW de, Giesen AM, Monnens LAH, Blom H (1999) Treatment of hyperhomocysteinemia in children on dialysis by folic acid. Pediatr Nephrol 13:583-585
22. Kang HG, Ha IS, Cheong HI, Choi Y (2001) Effect of B vitamin on hyperhomocysteinemia in children with chronic renal failure. Pediatr Nephrol 16:C168
23. Chauveau P, Chadefaux B, Coude M, Aupetit J, Kamoun P, Jungers P (1996) Longterm folic acid (but not pyridoxine) supplementation lowers elevated plasma homocysteine level in chronic renal failure. Miner Electrolyte Metab 22:106-109
24. Touam M, Zingraff J, Jungers P, Chadefauz-Vekemans B, Drueke T, Massy ZA (1999) Effective correction of hyperhomocysteinemia in hemodialysis patients by intravenous folinic acid and pyridoxine therapy. Kidney Int 56:2292-2296
25. Hoffer LF, Bank I, Hongsprahbas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE (2000) A tale of two homocysteines - and two hemodialysis units. Metabolism 49:215-219
26. Van Guldener C, Janssen MJFM, Lambert J, Wee PM ter, Jakobs C, Donker AJM, Stehouwer CDA (1998) No change in impaired endothelial function after long-term folic acid therapy of hyperhomocysteinaemia in haemodialysis patients. Nephrol Dial Transplant 13:106-112
27. Harker LA, Ross R, Slichter SJ, Scott CR (1976) Homocystine-induced arteriosclerosis: the role of endothelial cell injury and platelet response in its genesis. J Clin Invest 58:731-741
28. Lentz SR, Sobey CT, Peigors DJ, Bhopatkar MY, Faraci FM, Malinow MR, Heistad DD (1996) Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J Clin Invest 98:24-29