Sustained reduction of hyperhomocysteinaemia with folic acid supplementation in predialysis patients

Nephrology Dialysis Transplantation

Volumn 14, Issue 12, 1999, Pages 2903-2906

  Jungers, Paul ^a   Joly, Dominique ^a   Massy, Ziad ^a   Chauveau, Philippe ^a   Nguyen, Anh Thu ^a   Aupetit, Joëlle ^a   Chadefaux, Bernadette ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Chronic renal failure; Folic acid; Hyperhomocysteinaemia; Predialysis

Indexed keywords

CREATININE; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PYRIDOXINE; RECOMBINANT ERYTHROPOIETIN;

ADULT; AGED; ARTICLE; CHRONIC KIDNEY FAILURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; FOLIC ACID BLOOD LEVEL; HEMODIALYSIS; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; VITAMIN SUPPLEMENTATION;

EID: 0032759969     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/14.12.2903     Document Type: Article

References (25)

1. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991; 324: 1149-1155
2. Stampfer MJ, Malinow MR, Willett WC. A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians. J Am Med Assoc 1992; 268: 877-881
3. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997; 337: 230-236
4. Chauveau P, Chadefaux B, Coude M, Aupetit J, Hannedouche T, Kamoun P, Jungers P. Increased plasma homocysteine concentration in patients with chronic renal failure. Miner Electrolyte Metab 1992; 18: 196-198
5. Chauveau P, Chadefaux B, Coudé M, Aupetit J, Hannedouche T, Kamoun P, Jungers P. Hyperhomocysteinemia, a risk factor for atherosclerosis in chronic uremic patients. Kidney Int 1993; 43 [Suppl. 41]: S72-S77
6. Bostom A, Lathrop L. Hyperhomocysteinaemia in end-stage renal disease: prevalence, etiology and potential relationship to arteriosclerotic outcomes. Kidney Int 1997; 52: 10-20
7. Parfrey PS. Cardiac and cerebrovascular disease in chronic uremia. Am J Kidney Dis 1993; 21: 77-80
8. Jungers P, Nguyen-Khoa T, Massy ZA, Zingraff J, Labrunie M, Descamps-Latscha B, Man NK. Incidence of atherosclerotic arterial occlusive accidents in predialysis and dialysis patients: a multicentric study in the Ile de France district. Nephrol Dial Transplant 1999; 14: 898-902
9. Jungers P, Chauveau P, Blandin O, Chadefaux B, Aupetit J, Labrunie M, Descamps-Latscha B, Kamoun P. Hyperhomocysteinemia is associated with atherosclerotic occlusive arterial accidents in predialysis chronic renal failure patients. Miner Electrolyte Metab 1997; 23: 170-173
10. Massy ZA, Chadefaux-Vekemans B, Chevalier A, Bader CA, Drücke TB, Legendre C, Lacour B, Kamoun P, Kreis H. Hyperhomocysteinaemia: a significant risk factor for cardiovascular disease in renal ransplant recipients. Nephrol Dial Transplant 1994; 9: 1103-1108
11. Bostom AG, Shemin D, Verhoef P, Nadeau MR, Jacques PF, Selhub J, Dworkin L, Rosenberg IH. Elevated fasting total plasma homocysteine level and cardiovascular disease outcomes in maintenance dialysis patients: a prospective study. Arterioscler Thromb Vasc Biol 1997; 17: 2554-2558
12. Wilcken DEL, Dudman NPB, Tyrrell PA, Robertson MR. Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: possible implications for prevention of vascular disease. Metabolism 1988; 37: 697-701
13. Chauveau P, Chadefaux B, Coudé M, Aupetit J, Kamoun P, Jungers P. Long-term folic acid (but not pyridoxine) supplementation lowers elevated plasma homocysteine level in chronic renal failure. Miner Electrolyte Metab 1996; 22: 106-109
14. Arnadottir M, Brattstrom L, Simonsen O, Thysell H, Hultberg B, Anderson A, Nilsson-Ehle P. The effect of high-dose pyridoxine and folic acid supplementation on serum lipid and plasma homocysteine concentrations in dialysis patients. Clin Nephrol 1993; 40: 236-240
15. Bostom AG, Shemin D, Lapane KL, Hume AL, Yoburn D, Nadeau MR, Bendich A, Selhub J, Rosenberg IH. High dose B-vitamin treatment of hyperhomocysteinemia in dialysis patients. Kidney Int 1996; 49: 147-152
16. Janssen MJ, Van Guldener C, De Jong GMT, Van den Berg M, Stehouver CDA, Donker AJM. Folic acid treatment of hyperhomocysteinemia in dialysis patients. Miner Electrolyte Metab 1996; 22: 110-114
17. Van Guldener C, Janssen MJFM, Lambert J, Ter Wee PM, Jakobs C, Donker AJM, Stehouwer CDA. No change in impaired endothelial function after long-term folic acid therapy of hyperhomocysteinaemia in haemodialysis patients. Nephrol Dial Transplant 1998; 13: 106-112
18. Van Guldener C, Janssen MJFM, Lambert J, Ter Wee PM, Donker AJM, Stehouwer CDA. Folic acid treatment of hyperhomocysteinemia in peritoneal dialysis patients: no change in endothelial function after long-term therapy. Perit Dial Int 1998; 18: 282-289
19. Refsum H, Heiland S, Ueland PM. Radioenzymatic determination of homocysteine in plasma and urine. Clin Chem 1985; 31: 624-628
20. Chadefaux B, Coudé M, Hamet M, Aupetit J, Kamoun P. Rapid determination of total homocysteine in plasma. Clin Chem 1989; 35: 2002
21. Cockcroft DW, Gault DA. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31-41
22. De Santo NG, Coppola S, Anastasio P, Coscarella G, Capasso G, Bellini L, Santangelo R, Massimo L, Siciliano A. Predicted creatinine clearance to assess glomerular filtration rate in chronic renal disease in humans. Am J Nephrol 1991; 11: 181-185
23. Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IG. Vitamin status and intake as primary determinants of hyperhomocysteinemia in an elderly population. J Am Med Assoc 1993; 270: 2693-2698
24. Robinson K, Gupta A, Dennis VW et al. Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrations. Circulation 1996; 94: 2743-2748
25. Man NK, Zingraff J, Jungers P. Long-term hemodialysis. Kluwer Academic Publishers, Dordrecht, 1995