Disialoganglioside G D2 and a novel tumor antigen: Potential targets for immunotherapy of desmoplastic small round cell tumor

Medical and Pediatric Oncology

Volumn 39, Issue 6, 2002, Pages 547-551

  Modak, Shakeel ^a   Gerald, William ^a   Cheung, Nai Kong V ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Antibodies; Desmoplastic small round cell tumor; Immunotherapy; Monoclonal; Tumor antigen

Indexed keywords

ANTINEOPLASTIC AGENT; DISIALOGANGLIOSIDE GD2; DOXORUBICIN; GANGLIOSIDE GD2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 3F8; MONOCLONAL ANTIBODY 8H9; TUMOR ANTIGEN; UNCLASSIFIED DRUG; 3F8 ANTIBODY; DIAGNOSTIC AGENT; GANGLIOSIDE; GANGLIOSIDE, GD2; IMMUNOGLOBULIN G; MEMBRANE ANTIGEN;

ADOLESCENT; ADULT; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CANCER IMMUNOTHERAPY; CANCER RADIOTHERAPY; CELL MEMBRANE; CLINICAL ARTICLE; CONTROLLED STUDY; DESMOPLASTIC SMALL ROUND CELL TUMOR; DISEASE COURSE; DRUG TARGETING; EPITHELIUM TUMOR; FEMALE; FROZEN SECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MESENCHYMOMA; MOUSE; NEUROECTODERM TUMOR; NONHUMAN; PRIORITY JOURNAL; SARCOMA; SERODIAGNOSIS; STROMA; TUMOR CELL; IMMUNOLOGICAL PROCEDURES; IMMUNOLOGY; IMMUNOTHERAPY; MIDDLE AGED; NEOPLASM;

ADOLESCENT; ADULT; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; ANTIGENS, SURFACE; FEMALE; GANGLIOSIDES; HUMANS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; IMMUNOLOGIC TESTS; IMMUNOTHERAPY; MALE; MIDDLE AGED; NEOPLASMS;

EID: 0036882276     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/mpo.10151     Document Type: Article

References (26)

1. Gerald WL, Miller HK, Battifora H, et al. Intra-abdominal desmoplastic small round cell tumor. Report of 19 cases of a distinctive type of high-grade polyphenotypic malignancy affecting young individuals. Am J Surg Pathol 1991;15:499-513.
2. Ordonez NG, El-Naggar AK, Ro JY, et al. Intra-abdominal desmoplastic small cell tumor: A light microscopic, immunocytochemical, ultrastructural, and flow cytometric study. Hum Pathol 1993;24:850-865.
3. Ladanyi M, Gerald W. Fusion of the EWS and WTI genes in the desmoplastic small round cell tumor. Cancer Res 1994;54:2837-2840.
4. Lee SB, Kolquist KA, Nichols K, et al. The EWS-WTI translocation product induces PDGFA in desmoplastic small round cell tumour. Nat Genet 1997;17:309-313.
5. Froberg K, Brown RE, Gaylord H, et al. Intra-abdominal desmoplastic small round cell tumor: Immunohistochemical evidence for up-regulation of autocrine and paracrine growth factors. Ann Clin Lab Sci 1999;29:78-85.
6. Kushner BH, LaQuaglia MP, Wollner N, et al. Desmoplastic small round-cell tumor: Prolonged progression survival with aggressive multimodality therapy. J Clin Oncol 1996;14:1526-1531.
7. D2 antibody treatment of minimal residual stage 4 neuroblastoma diagnosed at more than 1 year of age. J Clin Oncol 1998;16:3053- 3060.
8. Cheung NK, Saarinen U, Neely J, et al. Monoclonal antibodies to a glycolipid antigen on human neuroblastoma cells. Cancer Res 1985;45:2642-2649.
9. Kramer K, Gerald W, Le Sauteur L, et al. Prognostic value of TrkA protein detection by monoclonal antibody 5C3 in neuroblastoma. Clin Cancer Res 1996;2:1361 -1367.
10. Gonzalez-Crussi F, Crawford SE, Sun CJ. Intra-abdominal desmoplastic small tumors with divergent differentiation. Observation on three cases of childhood. Am J Surg Pathol 1991;15:499-513.
11. Ordonez NG. Desmoplastic small round cell tumor: II: An ultrastructural and immunohistochemical study with emphasis on new immunohistochemical markers. Am J Surg Pathol 1998;22: 1314-1327.
12. Gerald WL, Ladanyi ML, De Alava E, et al. Clinical pathologic, and molecular spectrum of tumors associated with t(11;22) (p13;q12): Desmoplastic small round-cell tumor and its variants. J Clin Oncol 1998;16:3028-3036.
13. Weidner N, Tjoe J. Immunohistochemical profile of monoclonal antibody O13: Antibody that recognizes glycoprotein p30/32MIC2 and is useful in diagnosing Ewing's sarcoma and peripheral neuroepithelioma. Am J Surg Pathol 1994;18:486-494.
14. De Leij L, Helrich W, Stein R, et al. SCLC-cluster-2 antibodies detect the pancarcinoma/epithelial glycoprotein E GP-2. Int J Cancer 1994;8 (Suppl):60-63.
15. Barnoud R, Sabourin J, Pasquier D, et al. Immunohistochemical expression of WT1 by desmoplastic small round cell tumor. A comparative study with other small round cell tumors. Am J Surg Pathol 2000;24:830-836.
16. D2-specific monoclonal antibody 3F8 in human osteosarcoma. Cancer Res 1987;47:5377-5381.
17. D3 on human soft tissue sarcomas. Cancer 1992;70:633-638.
18. Cheung NK, Kushner BH, Yeh SDJ, et al. 3F8 monoclonal antibody treatment of patients with stage 4 neuroblastoma: A phase II study. Int J Oncol 1998;12:1299-1306.
19. Yeh SD, Larson SM, Burch L, et al. Radioimmunodetection of neuroblastoma with iodine-131-3F8: Correlation with biopsy, iodine-131-metaiodobenzylguanidine and standard diagnostic modalities. J Nucl Med 1991;32:769-776.
20. D2 ganglioside monoclonal antibody 3F8: A pilot trial. Eur J Nucl Med 1996;23:145-149.
21. D2 specific monoclonal antibody 3F8: A phase I study in patients with neuroblastoma and malignant melanoma. J Clin Oncol 1987;5: 1430-1440.
22. D2 loss following monoclonal antibody therapy is rare in neuroblastoma. Clin Cancer Res 1998;4:2135-2139.
23. Cheung NK, Heller G, Kushner BH, et al. Detection of neuroblastoma in bone marrow by immunocytology: Is a single marrow aspirate adequate? Med Pediatr Oncol 1999;32:84-87.
24. GD monoclonal antibodies: Correlation with patient survival. Cancer Res 1994;54:2228-2233.
25. Modak S, Kramer K, Gultekin SH, et al. Monoclonal antibody 8H9 targets a novel cell surface antigen expressed by a wide spectrum of human solid tumors. Cancer Res 2001;61:4048-4054.
26. Merino M, Navid F, Christensen N, et al. Immunomagnetic purging of Ewing's sarcoma from blood and bone marrow: Quantitation by real-time polymerase chain reaction. J Clin Oncol 2001;19:3649-3659.