Management and treatment of hirsutism in the elderly woman

Annals of Long-Term Care

Volumn 10, Issue 11, 2002, Pages 41-47

  Legro, Richard S ^a,b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANDROGEN; DEXAMETHASONE; EFLORNITHINE; FINASTERIDE; FLUTAMIDE; GLUCOCORTICOID; GONADORELIN AGONIST; PLACEBO; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; SPIRONOLACTONE;

ADJUVANT THERAPY; AFRICAN TRYPANOSOMIASIS; AGING; ALOPECIA; ANDROGEN SYNTHESIS; CLINICAL EXAMINATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIFFERENTIAL DIAGNOSIS; DISEASE EXACERBATION; DRUG ABSORPTION; DRUG INDICATION; DRUG POTENCY; DRUG TOLERABILITY; DRY SKIN; DYSLIPIDEMIA; ELDERLY CARE; ELECTROLYSIS; ENZYME INHIBITION; FEMALE; FEMINIZATION; FOOD AND DRUG ADMINISTRATION; HAIR LOSS; HEPATITIS; HIRSUTISM; HORMONE SUBSTITUTION; HUMAN; HYPERKALEMIA; INHIBITION KINETICS; INSULIN RESISTANCE; LABORATORY TEST; LASER; LIVER TOXICITY; MENOPAUSE; NEPHROTOXICITY; PROSTATE CARCINOMA; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RASH; REGULATORY MECHANISM; REVIEW; SIDE EFFECT; SKIN IRRITATION; TERATOGENICITY; TREATMENT OUTCOME; VIRILIZATION;

EID: 0036880015     PISSN: 15247929     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (27)

1. Burger HG, Dudley EC, Cui J, et al. A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone binding globulin levels through the menopause transition. J Clin Endocrinol Metab 2000;85(8):2832-2838.
2. Hatch R, Rosenfield RL, Kim MH, Tredway D. Hirsutism: Implications, etiology, and management. Am J Obstet Gynecol 1981;140(7):815-830.
3. Derksen J, Moolenaar AJ, Van Seters AP, Kock DF. Semiquantitative assessment of hirsutism in dutch women. Br J Dermatol 1993;128(3):259-263.
4. Ayuk P, Stringfellow H, Donnai P, et al. Hirsutism of recent onset with marked hyperandrogenaemia and ovarian hyperthecosis after the menopause. Ann Clin Biochem 1998;35(Pt 1):145-148.
5. Koroscil TM, Harter SB, Ouweleen J, Blauer KL. Use of a gonadotropin releasing hormone agonist in the evaluation of postmenopausal virilization due to ovarian hyperthecosis. A case report. J Reprod Med 1996;41:259-262.
6. Fuller PJ, Pettigrew IG, Pike JW, Stockigt JR. An adrenal adenoma causing virilization of mother and infant. Clin Endocrinol (Oxf) 1983;18(2):143-153.
7. Phillips E, Bauman C. Safety surveillance of esterified estrogens-methyl-testosterone (Estratest and Estratest HS) replacement therapy in the United States. Clin Ther 1997;19(5):1070-1084.
8. Winters SJ, Talbolt E, Guzick DS, et al. Serum testosterone levels decrease in middle age in women with the polycystic ovary syndrome. Fertil Steril 2000;73(4):724-729.
9. Waggoner W, Boots LR, Azziz R. Total testosterone and DHEAS levels as predictors of androgen-secreting neoplasms: A populational study. Gynecol Endocrinol 1999;13(6):394-400.
10. De Leo V, Fulghesu AM, Ia Marca A, et al. Hormonal and clinical effects of GnRH-Agonist alone, or in combination with a combined oral contraceptive or flutamide in women with severe hirsutism. Gynecol Endocrinol 2000;14(6):411-416.
11. Balfour JA, McClellan K. Topical eflornithine. Am J Clin Dermatol 2001;2(3):197-201.
12. Malhotra B, Noveck R, Behr D, Palmisano M. Percutaneous absorption and pharmacokinetics of eflornithine HCl 13.9% cream in women with unwanted facial hair. J Clin Pharmacol 2001;41(9):972-978.
13. Simon J, Klaiber E, Wiita B, Bowen A, Yang HM. Differential effects of estrogen-androgen and estrogen-only therapy on vasomotor symptoms, gonadotropin secretion, and endogenous androgen bioavailability in postmenopausal women. Menopause 1999;6(2):138-146.
14. Falselti L, De Fusco D, Eleftheriou G, Rosina B. Treatment of hirsutism by finasteride and flutamide in women with polycystic ovary syndrome. Gynecol Endocrinol 1997;11:251-257.
15. Wong IL, Morris RS, Chang L, et al. A prospective randomized trial comparing finasteride to spironolactone in the treatment of hirsute women. J Clin Endocrinol Metab 1995;80(1):233-238.
16. Moghetti P, Tosi F, Tosti A,et al. Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: A randomized, double blind placebo-controlled trial. J Clin Endocrinol Metab 2000;85(1):89-94.
17. Lee O, Farquhar C, Toomath R, Jepson R. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. Cochrane Database of Systematic Reviews 2000;(2):CD000194.
18. Pucci E, Genazzani AD, Monzani F, et al. Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic ovary syndrome. Gynecol Endocrinol 1995;9(3):221-228.
19. Moghelti P, Castello R, Magnani CM, et al. Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism. J Clin Endocrinol Metab 1994;79(4):1115-1121.
20. Fruzzelti F, de Lorenzo D, Parrini D, Ricci C. Effects of finasteride, a 5 alpha-reductase inhibitor, on circulating androgens and gonadotropin secretion in hirsute women. J Clin Endocrinol Metab 1994;79(3):831-835.
21. Riltmaster RS, Thompson DL. Effect of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: The relative importance of the ovary and the adrenal in the pathogenesis of hirsutism. J Clin Endocrinol Metab 1990;70:1096-1102.
22. Judd HL, Judd GE, Lucas WE, Yen SS. Endocrine function of the postmenopausal ovary: Concentration of androgens and estrogens in ovarian and peripheral vein blood. J Clin Endocrinol Metab 1974;39(6):1020-1024.
23. Inaba M, Anthony J, McKinstry C. Histologic study of the regeneration of axillary hair after removal with subcutaneous tissue shaver. J Invest Dermatol 1979;72(5):224-231.
24. Richards RN, Uy M, Meharg G. Temporary hair removal in patients with hirsutism: A clinical study. Cutis 1990;45(3):199-202.
25. Dierickx CC. Hair removal by lasers and intense pulsed light sources. Sem Cutan Med Surg 2000;19(4):267-275.
26. Dierickx CC, Grossman MC, Farinelli WA, Anderson RR. Permanent hair removal by normal-mode ruby laser. Arch Dermatol 1998;134(7):837-842.
27. Handrick C, Alster TS. Comparison of long-pulsed diode and long pulsed alexandrite lasers for hair removal: A long-term clinical and histologic study. Dermatol Surg 2001;27(7):622-626.