How Bayer makes decisions to develop new drugs

Interfaces

Volumn 32, Issue 6, 2002, Pages 77-90

  Stonebraker, Jeffrey S ^a  

^a BAYER CORPORATION   (United States)

Author keywords

Decision analysis: applications; Industries: pharmaceutical

Indexed keywords

EID: 0036876864     PISSN: 00922102     EISSN: None     Source Type: Journal    
DOI: 10.1287/inte.32.6.77.6475     Document Type: Article

References (20)

1. Balthasar, H. U., R. A. A. Boschi, M. M. Menke. 1978. Calling the shots in R&D. Harvard Bus. Rev. 56(May-June) 151-160.
2. Bodily, S. E., M. S. Allen. 1999. A dialogue process for choosing value-creating strategies. Interfaces 29(6) 16-28.
3. Boschi, R. A. A., H. U. Balthasar, M. M. Menke. 1979. Quantifying and forecasting exploratory research success. Res. Management 22(5) 14-21.
4. DiMasi, J. A. 1995. New drug development: Cost, risk, and complexity. Drug Information J. 29(2) 375-384.
5. Grabowski, H., J. Vernon. 1994. Returns to R&D on new drug introductions in the 1980s. J. Health Econom. 13(4) 383-406.
6. Halliday, R. G., S. R. Walker, C. E. Lumley. 1992. R&D philosophy and management in the world's leading pharmaceutical companies. J. Pharm. Med. 2(3) 139-154.
7. Keefer, D. L. 1995. Facilities evaluation under uncertainty: Pricing a refinery. Interfaces 25(6) 57-66.
8. _, S. E. Bodily. 1983. Three-point approximation for continuous random variables. Management Sci. 29(5) 595-609.
9. Keeney, R. 1992. Value-Focused Thinking. Harvard University Press, Cambridge, MA.
10. Merkhofer, M. W. 1987. Quantifying judgmental uncertainty: Methodology, experiences, and insights. IEEE Trans. Systems, Man, Cybernetics SMC-17(5) 741-752.
11. Neudeck, B. L., K. Blumenschein, E. D. Endean, F. K. Loh, R. P. Rapp. 1997. Intra-arterial urokinase versus surgery for acute peripheral arterial occlusion. Amer. J. Health-System Pharm. 54(17) 1963-1968.
12. Ouriel, K., F. J. Veith, A. A. Sasahara. 1996. Thrombolysis on peripheral arterial surgery: Phase I results. J. Vascular Surgery 23(1) 64-73.
13. _, _, _. 1998. A comparison of recombinant urokinase with vascular surgery as initial treatment for acute arterial occlusion of the legs. New England J. Medicine 338(16) 1105-1111.
14. Poland, W. B. 1999. Simple probabilistic evaluation of portfolio strategies. Interfaces 29(6) 75-83.
15. Schmidt, R. L. 1996. A stochastic optimization model to improve production planning and R&D resource allocation in biopharmaceutical production processes. Management Sci. 42(4) 603-617.
16. Shephard, G. G., C. W. Kirkwood. 1994. Managing the judgmental probability elicitation process: A case study of analyst/manager interaction. IEEE Trans. Engrg. Management 41(4) 414-425.
17. Spetzler, C. S., C.-A. S. Staël von Holstein. 1975. Probability encoding in decision analysis. Management Sci. 22(3) 340-352.
18. STILE Investigators. 1994. Results of a prospective randomised trial evaluating surgery versus thrombolysis for ischaemia of the lower extremity. Ann. Surgery 220(3) 251-266.
19. Struck, M. M. 1994. Biopharmaceutical R&D success rates and development times. Bio/Technology 12(July) 674-677.
20. Tiggemann, R. F., D. A. Dworaczyk, H. Sabel. 1998. Project portfolio management: A powerful strategic weapon in pharmaceutical drug development. Drug Information J. 32(3) 813-824.