메뉴 건너뛰기




Volumn 22, Issue 6 C, 2002, Pages 4065-4071

Induction of Epstein-Barr virus (EBV) reactivation in Raji cells by doxorubicin and cisplatin

Author keywords

12 O Tetradecanoylphorbol 13 acetate (TPA); BMRF 1; BZLF1; Cisplatin; Doxorubicin; Epstein Barr virus (EBV); Viral reactivation; ZEBRA

Indexed keywords

BUTYRIC ACID; CALCIMYCIN; CALCIUM IONOPHORE; CISPLATIN; DOXORUBICIN; IMMUNOGLOBULIN ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSFORMING GROWTH FACTOR BETA; VIRUS PROTEIN;

EID: 0036875694     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (15)

References (47)
  • 1
    • 0030267198 scopus 로고    scopus 로고
    • Pathogenesis of Epstein-Barr virus and its associated malignancies
    • Raab-Traub N: Pathogenesis of Epstein-Barr virus and its associated malignancies. Semin Virol 7: 315-323, 1996.
    • (1996) Semin Virol , vol.7 , pp. 315-323
    • Raab-Traub, N.1
  • 2
    • 0000942113 scopus 로고    scopus 로고
    • Epstein-Barr virus
    • (Fields BN, Knipe DM, Howley PM, et al eds). Philadelphia, Lippicott-Raven Publishers
    • Rickinson AB and Kieff E: Epstein-Barr virus. In: Fields Virology, 3 ed (Fields BN, Knipe DM, Howley PM, et al eds). Philadelphia, Lippicott-Raven Publishers, 1996, pp. 2343-2496.
    • (1996) Fields Virology, 3 Ed. , pp. 2343-2496
    • Rickinson, A.B.1    Kieff, E.2
  • 3
    • 0033610075 scopus 로고    scopus 로고
    • A model for persistent infection with Epstein-Barr virus: The stealth virus of human B cells
    • Thorley-Lawson DA and Babcock GJ: A model for persistent infection with Epstein-Barr virus: the stealth virus of human B cells. Life Science 65: 1433-1453, 1999.
    • (1999) Life Science , vol.65 , pp. 1433-1453
    • Thorley-Lawson, D.A.1    Babcock, G.J.2
  • 4
    • 0030221665 scopus 로고    scopus 로고
    • Epstein-Barr virus in Hodgkin's disease
    • Herbst H: Epstein-Barr virus in Hodgkin's disease. Semin Cancer Biol 7: 183 -189, 1996.
    • (1996) Semin Cancer Biol , vol.7 , pp. 183-189
    • Herbst, H.1
  • 6
    • 0030221501 scopus 로고    scopus 로고
    • Epstein-Barr virus infection and the pathogenesis of nasopharyngeal carcinoma: Viral gene expression, tumour cell phenotype, and the role of the lymphoid stroma
    • Niedobitek G, Agathanggelou A and Nicholls JM: Epstein-Barr virus infection and the pathogenesis of nasopharyngeal carcinoma: viral gene expression, tumour cell phenotype, and the role of the lymphoid stroma. Semin Cancer Biol 7: 165-174, 1996.
    • (1996) Semin Cancer Biol , vol.7 , pp. 165-174
    • Niedobitek, G.1    Agathanggelou, A.2    Nicholls, J.M.3
  • 7
    • 0030221507 scopus 로고    scopus 로고
    • Epstein-Barr virus and gastric carcinoma
    • Osato T and Imai S: Epstein-Barr virus and gastric carcinoma. Semin Cancer Biol 7: 175-182, 1996.
    • (1996) Semin Cancer Biol , vol.7 , pp. 175-182
    • Osato, T.1    Imai, S.2
  • 8
    • 0030202943 scopus 로고    scopus 로고
    • Introduction: Epstein-Barr virus and non-B cell tumours
    • Young LS: Introduction: Epstein-Barr virus and non-B cell tumours. Semin Cancer Biol 7: 163-164, 1996.
    • (1996) Semin Cancer Biol , vol.7 , pp. 163-164
    • Young, L.S.1
  • 9
    • 0017876123 scopus 로고
    • Persisting oncogenic herpes virus induced by the tumor promoter TP
    • zur Hausen H, O'Neill FJ, Freese JK and Hecker E: Persisting oncogenic herpes virus induced by the tumor promoter TP. Nature 272: 373-375, 1978.
    • (1978) Nature , vol.272 , pp. 373-375
    • Zur Hausen, H.1    O'Neill, F.J.2    Freese, J.K.3    Hecker, E.4
  • 10
    • 0018930642 scopus 로고
    • Induction of Epstein-Barr virus antigens in human lymphoblastoid P3HR-1 cells with culture fluid of Fusobacteriumtum nucleatum
    • Ito Y, Kishishita M and Yanase S: Induction of Epstein-Barr virus antigens in human lymphoblastoid P3HR-1 cells with culture fluid of Fusobacteriumtum nucleatum. Cancer Res 40: 4329-4330, 1980.
    • (1980) Cancer Res , vol.40 , pp. 4329-4330
    • Ito, Y.1    Kishishita, M.2    Yanase, S.3
  • 11
    • 0022455453 scopus 로고
    • Calcium modulation activates Epstein-Barr virus genome in latently infected cells
    • Faggioni A, Zompetta C, Grimaldi S, Barile G, Frati L and Lazdins J: Calcium modulation activates Epstein-Barr virus genome in latently infected cells. Science 232: 1554-1556, 1986.
    • (1986) Science , vol.232 , pp. 1554-1556
    • Faggioni, A.1    Zompetta, C.2    Grimaldi, S.3    Barile, G.4    Frati, L.5    Lazdins, J.6
  • 12
    • 0028177364 scopus 로고
    • Endogenous TGF-beta contributes to the induction of the EBV lytic cycle in two Burkitt lymphoma cell lines
    • di Renzo L, Altiok A, Klein G and Klein E: Endogenous TGF-beta contributes to the induction of the EBV lytic cycle in two Burkitt lymphoma cell lines. Int J Cancer 57: 914-919, 1994.
    • (1994) Int J Cancer , vol.57 , pp. 914-919
    • Di Renzo, L.1    Altiok, A.2    Klein, G.3    Klein, E.4
  • 13
    • 0018129364 scopus 로고
    • Activation of latent Epstein-Barr virus by antibody to human IgM
    • Tovey MG, Lenoir G and Begon-Lours J: Activation of latent Epstein-Barr virus by antibody to human IgM. Nature 276: 270-272, 1978.
    • (1978) Nature , vol.276 , pp. 270-272
    • Tovey, M.G.1    Lenoir, G.2    Begon-Lours, J.3
  • 14
    • 0024590981 scopus 로고
    • Synchronous and sequential activation of latently infected Epstein-Barr virus genomes
    • Takada K and Ono Y: Synchronous and sequential activation of latently infected Epstein-Barr virus genomes. J Virol 63: 445-449, 1989.
    • (1989) J Virol , vol.63 , pp. 445-449
    • Takada, K.1    Ono, Y.2
  • 15
    • 0025341653 scopus 로고
    • Activation of latent EBV via anti-IgG-triggered, second messenger pathways in the Burkitt's lymphoma cell line Akata
    • Daibata M, Humphreys RE, Takada K and Sairenji T: Activation of latent EBV via anti-IgG-triggered, second messenger pathways in the Burkitt's lymphoma cell line Akata. J Immunol 144: 4788-4793, 1990.
    • (1990) J Immunol , vol.144 , pp. 4788-4793
    • Daibata, M.1    Humphreys, R.E.2    Takada, K.3    Sairenji, T.4
  • 16
    • 0025220792 scopus 로고
    • The switch between latency and replication of Epstein-Barr virus
    • Miller G: The switch between latency and replication of Epstein-Barr virus. J Infect Disease 161: 833-844, 1990.
    • (1990) J Infect Disease , vol.161 , pp. 833-844
    • Miller, G.1
  • 17
    • 0030760456 scopus 로고    scopus 로고
    • Reactivation of Epstein-Barr virus: Regulation and function of BZLF 1 gene
    • Speck SH, Chatila T and Flemingtom E: Reactivation of Epstein-Barr virus: regulation and function of BZLF1 gene. Trends Microbiol 10: 399-405, 1997.
    • (1997) Trends Microbiol , vol.10 , pp. 399-405
    • Speck, S.H.1    Chatila, T.2    Flemingtom, E.3
  • 18
    • 0027199311 scopus 로고
    • Characteristic clinicopathologic features of Epstein-Barr virus-associated peripheral T-cell lymphoma
    • Cheng AL, Su IJ, Chen YC, Uen WC and Wang CH: Characteristic clinicopathologic features of Epstein-Barr virus-associated peripheral T-cell lymphoma. Cancer 72: 909-916, 1993.
    • (1993) Cancer , vol.72 , pp. 909-916
    • Cheng, A.L.1    Su, I.J.2    Chen, Y.C.3    Uen, W.C.4    Wang, C.H.5
  • 19
    • 0028206416 scopus 로고
    • Clinicopathological spectrum of haemophagocytic syndrome in Epstein-Barr virus-associated peripheral T-cell lymphoma
    • Yao M, Cheng AL, Su IJ, Lin MT, Uen WC, Tien HF, Wang CH and Chen YC: Clinicopathological spectrum of haemophagocytic syndrome in Epstein-Barr virus-associated peripheral T-cell lymphoma. Br J Haematol 87: 535-543, 1994.
    • (1994) Br J Haematol , vol.87 , pp. 535-543
    • Yao, M.1    Cheng, A.L.2    Su, I.J.3    Lin, M.T.4    Uen, W.C.5    Tien, H.F.6    Wang, C.H.7    Chen, Y.C.8
  • 21
    • 0027212267 scopus 로고
    • Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents
    • Tishler RB, Calderwood SK, Coleman N and Price BD: Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents. Cancer Res 53: 2212-2216, 1993.
    • (1993) Cancer Res , vol.53 , pp. 2212-2216
    • Tishler, R.B.1    Calderwood, S.K.2    Coleman, N.3    Price, B.D.4
  • 22
    • 0032514485 scopus 로고    scopus 로고
    • DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
    • Woo RA, McLure KG, Lees-Miller SP, Rancourt DE and Lee PWK: DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature 394: 700-704, 1998.
    • (1998) Nature , vol.394 , pp. 700-704
    • Woo, R.A.1    McLure, K.G.2    Lees-Miller, S.P.3    Rancourt, D.E.4    Lee, P.W.K.5
  • 23
    • 0029851730 scopus 로고    scopus 로고
    • Role of the stress-activated/c-Jun NH2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic agents
    • Osborn MT and Chambers TC: Role of the stress-activated/c-Jun NH2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic agents. J Biol Chem 172: 30950-30959, 1996.
    • (1996) J Biol Chem , vol.172 , pp. 30950-30959
    • Osborn, M.T.1    Chambers, T.C.2
  • 24
    • 0032499572 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase participates in the activation of NF-κB following DNA damage
    • Basu S, Rosenzwei KR, Youmell M and Price BD: The DNA-dependent protein kinase participates in the activation of NF-κB following DNA damage. Biochem Biophys Res Commun 247: 79-83, 1998.
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 79-83
    • Basu, S.1    Rosenzwei, K.R.2    Youmell, M.3    Price, B.D.4
  • 26
    • 0024469056 scopus 로고
    • Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos
    • Farrell PJ, Rowe DT, Rooney CM and Kouzarides T: Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos. EMBO J 8: 127-132, 1989.
    • (1989) EMBO J , vol.8 , pp. 127-132
    • Farrell, P.J.1    Rowe, D.T.2    Rooney, C.M.3    Kouzarides, T.4
  • 27
    • 0028197265 scopus 로고
    • The bZ1P transactivator of Epstein-Barr virus, BZLF1, functionally and physically interacts with the p65 subunit of NF-kappa B
    • Gutsch DE, Holley-Guthrie EA, Zhang Q, Stein B, Blanar MA, Baldwin AS and Kenney SC: The bZ1P transactivator of Epstein-Barr virus, BZLF1, functionally and physically interacts with the p65 subunit of NF-kappa B. Mol Cell Biol 14: 1939-1948,1994.
    • (1994) Mol Cell Biol , vol.14 , pp. 1939-1948
    • Gutsch, D.E.1    Holley-Guthrie, E.A.2    Zhang, Q.3    Stein, B.4    Blanar, M.A.5    Baldwin, A.S.6    Kenney, S.C.7
  • 28
    • 0031550772 scopus 로고    scopus 로고
    • The bZip dimerization domain of the Epstein-Barr virus BZLF1 (Z) protein mediates lymphoid-specific negative regulation
    • Hong Y, Holley-Guthrie E and Kenney S: The bZip dimerization domain of the Epstein-Barr virus BZLF1 (Z) protein mediates lymphoid-specific negative regulation. Virol 229: 36-48, 1997.
    • (1997) Virol , vol.229 , pp. 36-48
    • Hong, Y.1    Holley-Guthrie, E.2    Kenney, S.3
  • 29
    • 0028268278 scopus 로고
    • Functional and physical interaction between p53 and BZLF1: Implication for Epstein-Barr virus latency
    • Zhang Q, Gutsch D and Kenney S: Functional and physical interaction between p53 and BZLF1: implication for Epstein-Barr virus latency. Mol Cell Biol 14: 1929-1938, 1994.
    • (1994) Mol Cell Biol , vol.14 , pp. 1929-1938
    • Zhang, Q.1    Gutsch, D.2    Kenney, S.3
  • 30
    • 0021323223 scopus 로고
    • Two deletions in the Epstein-Barr virus genome of the Burkitt Lymphoma nonproducer line Raji
    • Polack A, Delius H, Zimber U and Bornkamm GW: Two deletions in the Epstein-Barr virus genome of the Burkitt Lymphoma nonproducer line Raji. Virol 133: 146-157, 1984.
    • (1984) Virol , vol.133 , pp. 146-157
    • Polack, A.1    Delius, H.2    Zimber, U.3    Bornkamm, G.W.4
  • 31
    • 0036190104 scopus 로고    scopus 로고
    • The chemopreventive compound curcumin is an efficient inhibitor of Epstein-Barr virus BZLF1 transcription in Raji DR-LUC cells
    • Hergenhahn M, Soto U, Weninger A, Polack A, Hsu CH, Cheng AL and Rosl F: The chemopreventive compound curcumin is an efficient inhibitor of Epstein-Barr virus BZLF1 transcription in Raji DR-LUC cells. Mol Carcinogenesis 33: 137-145, 2002.
    • (2002) Mol Carcinogenesis , vol.33 , pp. 137-145
    • Hergenhahn, M.1    Soto, U.2    Weninger, A.3    Polack, A.4    Hsu, C.H.5    Cheng, A.L.6    Rosl, F.7
  • 32
    • 0029964835 scopus 로고    scopus 로고
    • A novel method for real time quantitative RT-PCR
    • Gibson UE, Heid CA and Williams PM: A novel method for real time quantitative RT-PCR.Genome Res 6: 995-1001, 1996.
    • (1996) Genome Res , vol.6 , pp. 995-1001
    • Gibson, U.E.1    Heid, C.A.2    Williams, P.M.3
  • 34
    • 0025861818 scopus 로고
    • Detection of specific polymerase chain reaction product by utilizing the 5'3' exonuclease activity of Thermus aquaticus DNA polymerase
    • Holland PM, Abramson RD, Watson R and Gelfand DH: Detection of specific polymerase chain reaction product by utilizing the 5'3' exonuclease activity of Thermus aquaticus DNA polymerase. Proc Natl Acad Sci USA 88: 7276-7280, 1991.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7276-7280
    • Holland, P.M.1    Abramson, R.D.2    Watson, R.3    Gelfand, D.H.4
  • 35
    • 0023916915 scopus 로고
    • Induction of Epstein-Barr virus antigens by hydroxyurea
    • Novakova Z and Roubal J: Induction of Epstein-Barr virus antigens by hydroxyurea. Acta Virologica 32: 160-163, 1988.
    • (1988) Acta Virologica , vol.32 , pp. 160-163
    • Novakova, Z.1    Roubal, J.2
  • 36
    • 0021991338 scopus 로고
    • Enhanced expression of Epstein-Barr virus early antigens by antitubulin agents in a latently infected human lymphoblastoid cell
    • Fujita J, Yoshida O, Tokuda H, Sugawara K and Ito Y: Enhanced expression of Epstein-Barr virus early antigens by antitubulin agents in a latently infected human lymphoblastoid cell. Experientia 41: 372-373, 1985.
    • (1985) Experientia , vol.41 , pp. 372-373
    • Fujita, J.1    Yoshida, O.2    Tokuda, H.3    Sugawara, K.4    Ito, Y.5
  • 37
    • 0034667460 scopus 로고    scopus 로고
    • Activation of lytic Epstein-Barr virus (EBV) infection by radiation and sodium butyrate in vitro and in vivo: A potential method for treating EBV-positive malignancies
    • Westphal EM, Blackstock W, Feng W, Israel B and Kenney SC: Activation of lytic Epstein-Barr virus (EBV) infection by radiation and sodium butyrate in vitro and in vivo: a potential method for treating EBV-positive malignancies. Cancer Res 60: 5781-5788, 2000.
    • (2000) Cancer Res , vol.60 , pp. 5781-5788
    • Westphal, E.M.1    Blackstock, W.2    Feng, W.3    Israel, B.4    Kenney, S.C.5
  • 38
    • 0037086080 scopus 로고    scopus 로고
    • Chemotherapy induces lytic EBV replication and confers gancyclovir susceptibility to EBV-positive epithelial cell tumors
    • Feng WH, Isael B, Raab-Traub N, Busson P and Kenney SC: Chemotherapy induces lytic EBV replication and confers gancyclovir susceptibility to EBV-positive epithelial cell tumors. Cancer Res 62: 1920-1926, 2002.
    • (2002) Cancer Res , vol.62 , pp. 1920-1926
    • Feng, W.H.1    Isael, B.2    Raab-Traub, N.3    Busson, P.4    Kenney, S.C.5
  • 39
    • 0027379698 scopus 로고
    • Serine-173 of the Epstein-Barr virus ZEBRA protein is required for DNA binding and is a target for casein kinase II phosphorylation
    • Kolman RJL, Taylor N, Marshak DR and Miller G: Serine-173 of the Epstein-Barr virus ZEBRA protein is required for DNA binding and is a target for casein kinase II phosphorylation. Proc Natl Acad Sci USA 90: 10115-10119, 1993.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10115-10119
    • Kolman, R.J.L.1    Taylor, N.2    Marshak, D.R.3    Miller, G.4
  • 40
    • 0030947010 scopus 로고    scopus 로고
    • Alteration of a single serine in the basic domain of the Epstein-Barr virus ZEBRA protein separate its functions of transcriptional activation and disruption of latency
    • Francis A, Gradoville L and Miller G: Alteration of a single serine in the basic domain of the Epstein-Barr virus ZEBRA protein separate its functions of transcriptional activation and disruption of latency. J Virol 71: 3054-3061, 1997.
    • (1997) J Virol , vol.71 , pp. 3054-3061
    • Francis, A.1    Gradoville, L.2    Miller, G.3
  • 41
    • 0031687933 scopus 로고    scopus 로고
    • Activation of the Epstein-Barr virus transcription factor BZLF1 by 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation
    • Baumann M, Mischak H, Dammeier S, Kolch W, Gires O, Pich D, Zeidler R, Delecluse HJ and Hammerschidt W: Activation of the Epstein-Barr virus transcription factor BZLF1 by 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation. J Virol 72: 8105-8114, 1998.
    • (1998) J Virol , vol.72 , pp. 8105-8114
    • Baumann, M.1    Mischak, H.2    Dammeier, S.3    Kolch, W.4    Gires, O.5    Pich, D.6    Zeidler, R.7    Delecluse, H.J.8    Hammerschidt, W.9
  • 42
    • 0033021095 scopus 로고    scopus 로고
    • The interaction of mitogen-activated protein kinases to Epstein-Barr virus activation in Akata cells
    • Satoh T, Hoshikawa Y, Satoh Y, Kurata T and Sairenji T: The interaction of mitogen-activated protein kinases to Epstein-Barr virus activation in Akata cells. Virus genes 18: 57-64, 1999.
    • (1999) Virus Genes , vol.18 , pp. 57-64
    • Satoh, T.1    Hoshikawa, Y.2    Satoh, Y.3    Kurata, T.4    Sairenji, T.5
  • 43
    • 0034099654 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 stimulated expression of the Epstein-Barr virus BZLF1 immediate-early gene product ZEBRA by an indirect mechanism which requires the MAPK kinase pathway
    • Fahmi H, Cochet C, Hmama Z, Opolon P and Joab I: Transforming growth factor beta 1 stimulated expression of the Epstein-Barr virus BZLF1 immediate-early gene product ZEBRA by an indirect mechanism which requires the MAPK kinase pathway. J Virol 74: 5810-5818, 2000.
    • (2000) J Virol , vol.74 , pp. 5810-5818
    • Fahmi, H.1    Cochet, C.2    Hmama, Z.3    Opolon, P.4    Joab, I.5
  • 44
    • 0033982336 scopus 로고    scopus 로고
    • Epstein-Barr virus immediate-early proteins BZLF1 and BRLF1 activate ATF2 transcription factor by increasing the levels of phosphorylation p38 and c-Jun N-terminal kinases
    • Adamson AL, Darr D, Holley-Guthrie E, Johnson RA, Mauser A, Swenson J and Kenney S: Epstein-Barr virus immediate-early proteins BZLF1 and BRLF1 activate ATF2 transcription factor by increasing the levels of phosphorylation p38 and c-Jun N-terminal kinases. J Virol 74: 1224-1233, 2000.
    • (2000) J Virol , vol.74 , pp. 1224-1233
    • Adamson, A.L.1    Darr, D.2    Holley-Guthrie, E.3    Johnson, R.A.4    Mauser, A.5    Swenson, J.6    Kenney, S.7
  • 45
    • 0035919638 scopus 로고    scopus 로고
    • 12-O-tetradecanoylphorbol-13-acetate induces Epstein-Barr virus reactivation via NF-kappaB and AP-1 as regulated by protein kinase C and mitogen-activated protein kinase K
    • Gao X, Ikuta K, Tajima M and Sairenji T: 12-O-tetradecanoylphorbol-13-acetate induces Epstein-Barr virus reactivation via NF-kappaB and AP-1 as regulated by protein kinase C and mitogen-activated protein kinase K. Virol 286: 91-99, 2001.
    • (2001) Virol , vol.286 , pp. 91-99
    • Gao, X.1    Ikuta, K.2    Tajima, M.3    Sairenji, T.4
  • 46
    • 0025100316 scopus 로고
    • Role of herpes simplex virus reactivation in chemotherapy-induced oral mucositis
    • Redding SW: Role of herpes simplex virus reactivation in chemotherapy-induced oral mucositis. NCI Monographs 9: 103-105, 1990.
    • (1990) NCI Monographs , vol.9 , pp. 103-105
    • Redding, S.W.1
  • 47
    • 0032894969 scopus 로고    scopus 로고
    • Chemotherapy and bone marrow transplantation for cancer patients who are also chronic hepatitis B carriers: A review of the problem
    • Liang R, Lau GK and Kwong YL: Chemotherapy and bone marrow transplantation for cancer patients who are also chronic hepatitis B carriers: a review of the problem. J Clin Oncol 17: 394-398, 1999.
    • (1999) J Clin Oncol , vol.17 , pp. 394-398
    • Liang, R.1    Lau, G.K.2    Kwong, Y.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.