The role of N-acetyltransferase-2 and Glutathione S-transferase on the risk and aggressiveness of bladder cancer

Anticancer Research

Volumn 22, Issue 6 B, 2002, Pages 3801-3804

  Giannakopoulos, Xenofon ^a   Charalabopoulos, Konstantin ^a   Baltogiannis, Dimitrios ^a   Chatzikiriakidou, Anthi ^a   Alamanos, Yannis ^a   Georgiou, Ioannis ^a   Evangelou, Angelos ^a   Agnantis, Niki ^a   Sofikitis, Nikolaos ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

Author keywords

Bladder cancer; Glutathione s transferase; N acetyltransferase 2; Risk genotypes

Indexed keywords

ACYLTRANSFERASE; AROMATIC AMINE; CARCINOGEN; GLUTATHIONE TRANSFERASE; POLYCYCLIC AROMATIC COMPOUND;

ADULT; AGED; ARTICLE; BLADDER CANCER; BLADDER CARCINOGENESIS; CANCER GRADING; CANCER RISK; CANCER STAGING; CONTROLLED STUDY; DETOXIFICATION; ENVIRONMENTAL FACTOR; ENZYME ACTIVITY; ENZYME POLYMORPHISM; FEMALE; GENOTYPE; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

AGED; ARYLAMINE N-ACETYLTRANSFERASE; CARCINOMA, TRANSITIONAL CELL; CASE-CONTROL STUDIES; FEMALE; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; RISK FACTORS; URINARY BLADDER NEOPLASMS;

EID: 0036875488     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Perera FR: Environment and cancer: who are susceptible? Science 278: 1068-1073, 1997.
2. Silverman DT, Morrison AS and Devesa SS: Bladder cancer. In: Cancer Epidemiology and Prevention. Schottenfeld D, Fraumeni JF (eds), New York, Oxford, 1997.
3. Baltogiannis D, Tasos A, Voutsinas G, Dauaher H, Chambilomatis P and Giannakopoulos X: Bladder cancer mortality in the Epirus district population (Greece). Int Urol Nephrol 32: 377-379, 2001.
4. Lin HJ, Han C-Y, Lin BK and Hardy S: Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene. Pharmacogenetics 4: 125-134, 1994.
5. Hickman D and Sim E: Chromosomal localization of human genes for arylamine-N-acetyltransferase. Biochem J 297: 441, 1994.
6. Bell DA, Taylor JA, Paulson DF, Robertson SN, Mohler JL and Lucier GW: Genetic risk and carcinogen exposure: A common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst 85: 1159-1163, 1993.
7. D' Errico A, Malats N, Vineis P and Boffetta P: Review of studies of selected metabolic polymorphisms and cancer. In: Metabolic Polymorphisms and Susceptibility to Cancer, Vineis P, Malats N, Lang M, D' Errico A, Caporaso N, Cuzick J, Boffetta P (eds), Lyon, International Agency of Research of Cancer, 1999.
8. Green J, Banks E, Berrington A, Darby S, Deo H and Newton R: N-acetyltransferase-2 and bladder cancer: an overview and consideration of the evidence for gene-environment interaction. Br J Cancer 83: 412-17, 2000.
9. Johns LE and Houlston RJ: Glutathione S-transferase mul (gstm1) status and bladder cancer risk: a meta-analysis. Mutagenesis 5: 399-404, 2000.
10. Brockmoller J, Cascorbi I, Kerb R and Roots I: Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferase M1 and T1, microsomial epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk. Cancer Res 17: 3915-3925, 1996.
11. Kim WJ, Lee HL, Lee SC, Kim YT and Kim H: Polymorphisms of N-acetyltransferase 2, glutathione S-transferase no and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis. J Urol 164: 209-213, 2000.
12. Gabbani G, Hou SM, Nardini B, Marchioro M, Lambert B and Clonferpo E: GSTM1 and NAT2 genotypes and urinary mutagens in coke oven workers. Carcinogenesis 17: 1677-1681, 1996.
13. Schnakenberg E, Lustig M, Breuer R et al: Gender-specific effects of NAT2 and GSTM1 in bladder cancer. Clin Genet 4: 270-277, 2000.
14. Agundez JAG, Martinez C, Olivera M, Ledsema MC, Ladero JM and Benitez J: Molecular analysis of the arylamine N-acetyltransferase polymorphism in a Spanish population. Clin Pharmacol Ther 56: 202-209, 1994.
15. IARC: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Lyon, WHO, 1986.
16. Lower GM: Concepts in causality: chemically-induced human urinary bladder cancer. Cancer 49: 1056-1066, 1982.
17. Yu Mc, Ross RK, Chan KK et al: Glutathine S-transferase M1 genotype affects aminobiphenyl-hemoglobin adduct levels in white, black and Asian smokers and nonsmokers. Cancer Epidemiol Biomarkers Prev 4: 861-864, 1995.
18. Filiadis I, Georgiou I, Alamanos Y, Kranas V, Giannakopoulos X and Lolis D: Genotypes of N-acetyltransferase-2 and risk of bladder cancer: a case-control study. J Urol 161: 1672-165, 1999.
19. Georgiou I, Filiadis I, Alamanos Y, Bouda I, Giannakopoulos X and Lolis D: Glutathione S-transferase null genotypes in transitional cell bladder cancer. Eur Urol 37: 660-664, 2000.
20. Aktas D, Ozen H, Atsu N, Tekin A, Sozen S and Tuncbilek E: Glutathione S-transferase M1 gene polymorphism in bladder cancer patients. A marker for invasive bladder cancer? Cancer Genet Cytogenet 1: 1-4, 2001.
21. Risch A, Wallace DM, Bathers S and Sim E: Slow N-acetylation genotypes a susceptibility factor in occupational and smoking related bladder cancer. Hum Mol Genet 4: 231-236, 1995.
22. Viel JF and Challier B: Bladder cancer among French, farmers: does exposure to pesticides in vineyards play a part? Occup Environ Med 52: 587-592, 1995.
23. Marcus P, Hayes R, Vineis P et al: Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: A case-series meta-analysis of a gene-environment interaction. Cancer Epidemiol Biomarkers Prev 9: 461-467, 2000.