Enhancement of anti-tumor immunity by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal agent, in athymic nude mice bearing human salivary adenocarcinoma: Role of natural killer cells

Anticancer Research

Volumn 22, Issue 6 A, 2002, Pages 3229-3239

  Okamoto, Masato ^a   Ohe, Go ^a   Furuichi, Sachiko ^a   Nishikawa, Hidetomo ^a   Oshikawa, Tetsuya ^a   Tano, Tomoyuki ^a   Uddin Ahmed, Sharif ^a   Yoshida, Hideo ^a   Moriya, Yoichiro ^b   Matsubara, Shuzo ^b   Ryoma, Yoshiki ^b   Saito, Motoo ^b   Sato, Mitsunobu ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Anti tumor immunity; Lipoteichoic acid; NK cells; Nude mice; OK 432

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 2; LIPOTEICHOIC ACID; MESSENGER RNA; PICIBANIL; SPHINGOLIPID ACTIVATOR PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ADENOCARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHROMIUM 51 RELEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; LYMPH NODE CELL; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALIVARY GLAND CARCINOMA; STREPTOCOCCUS; TH1 CELL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR IMMUNITY;

ADENOCARCINOMA; ANIMALS; ANTIBODIES; CELL MOVEMENT; COMBINED MODALITY THERAPY; CYTOKINES; G(M1) GANGLIOSIDE; HUMANS; IMMUNOTHERAPY; KILLER CELLS, NATURAL; LIPOPOLYSACCHARIDES; LYMPHOCYTES; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PICIBANIL; RNA, MESSENGER; SALIVARY GLAND NEOPLASMS; TEICHOIC ACIDS; TH1 CELLS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0036870654     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Okamoto H, Shoin S, Koshimura S and Shimizu R: Studies on the anticancer and streptolysin S-forming abilities of hemolytic streptococci. Jpn J Microbiol 11: 323-336, 1967.
2. Fukui H, Koshihara Y, Magamuta M, Mizutani Y and Uchida A: Production of interleukin 6 by human spleen cells stimulated with streptococcal preparation OK-432. Immunol Lett 21: 127-130, 1989.
3. Ichimura O, Suzuki S, Saito M, Sugawara Y and Ishida N: Augmentation of interleukin I and interleukin 2 production by OK-432. Int J Immunopharmacol 7: 463-470, 1985.
4. Oshimi K, Kano S, Takaku F and Okumura K: Augmentation of mouse natural killer cell activity by a streptococcal preparation, OK- 432. J Natl Cancer Inst 65: 1265-1269, 1980.
5. Saito M, Ebina T, Koi M, Yamaguchi T, Kamade Y and Ishida N: Induction of interferon-γ in mouse spleen cells by OK-432, a preparation of Streptococcus pyogenes. Cell Immunol 68: 187-192, 1982.
6. Misaki T, Watanabe Y, Lida Y, Hidaka A, Kasagi K, Fukushima H and Konishi J: Recruitment of T lymphocytes and induction of tumor necrosis factor in thyroid cancer by a local immunotherapy. Cancer Immunol Immunother 35: 92-96, 1992.
7. Fujimto T, Duda RB, Azilbasi A, Chen X, Mai M and O'Donnell MA: Streptococcal preparation OK-432 is a potent inducer of IL-12 and a T helper cell 1 dominant state. J Immunol 158: 5619-5626, 1997.
8. Okamoto T, Harada M, Tamada K, Yoshida H, Ito O, Kong YY, Takenoyama M, Hirashima C, Matsuzaki G and Nomoto K: Local injection of OK-432 can augment the Th1 T-cell response in tumor-draining lymph node cells and increase their immunotherapeutical potential. Int J Cancer 70: 598-605, 1997.
9. Yamamoto K, Tanaka R, Yoshida S, Ono K, Mori H, Taniguchi Y, Oda T and Watanabe T: Effects of OK-432 on the proliferation and cytotoxicity of lymphokine-activated killer (LAK) cells. J Immunother 22: 33-40, 1999.
10. Okamoto M, Kaji R, Kasetani H, Yoshida H, Moriya Y, Saito M and Sato M: Purification and characterization of interferon-γ-inducing molecule of OK-432, a penicillin-killed streptococcal preparation, by monoclonal antibody neutralizing interferon-γ-inducing activity of OK-432. J Immunother 13: 232-242, 1993.
11. Takada H, Kawabata Y, Arakaki R, Kusumoto S, Fukase K, Suda Y, Yoshimura T, Kokeguchi S, Kato K, Komuro T, Tanaka N, Saito M, Yoshida T, Sato M and Kotani S: Molecular and structural requirements of a lipoteichoic acid from Enterococcus hirae ATCC 9790 for cytokine-inducing, anti-tumor, and antigenic activities. Infect Immun 63: 57-65, 1995.
12. Okamoto M, Gohda H, Ohe G, Yoshida H, Matsuno T, Saito M and Sato M: Cytokine-inducing activity and anti-tumor effect of liposome-incorporated interferon-γ-inducing molecule derived from OK-432, a streptococcal preparation. J Immunother 23: 94-103, 2000.
13. Okamoto M, Ohe G, Oshikawa T, Nishikawa H, Furuichi S, Yoshida H, Matsuno T, Saito M and Sato M: Induction of Th1-type cytokines by lipoteichoic acid-related preparation isolated from OK-432, a penicillin-killed streptococcal agent. Immunopharmacal 49: 363-376, 2000.
14. Okamoto M, Ohe G, Oshikawa T, Furuichi S, Nishikawa H, Tano T, Ahmed SU, Yoshida H, Moriya Y, Saito M and Sato M: Enhancement of anti-cancer immunity by a lipoteichoic-acid-related molecule isolated from a penicillin-killed group A Streptococcus. Cancer Immunol Immunother 50: 408-416, 2001.
15. Herberman RB and Ortaldo JR: The natural Killer cells: Their role in defense against diseases. Science 214: 24-30, 1981.
16. Orange JS, Wang B, Terhorst C and Biron CA: Requirement for natural killer cell-produced interferon γ in defense against murine cytomegalo-virus infection and enhancement of this defense pathway by interleukin 12 administration. J Exp Med 182: 1045-1056, 1995.
17. Biron CA, Nguyan KB, Pien GC, Cousens LP and Salazar-Mather TP: Natural killer cells in antiviral defense: Function and regulation by innate cytokines. Annu Rev Immunol 17: 189-220, 1999.
18. Shirasuna K, Sato M and Miyazaki T: A neoplastic epithelial duct cell line established from an irradiated human salivary gland. Cancer 48: 745-752, 1981.
19. Sato M, Harada K, Yoshida H, Yura Y, Azuma M, Iga H, Bando T, Kawamata H and Takegawa Y: Therapy for oral squamous cell carcinoma by tegafur and streptococcal agent OK-432 in combination with radiotherapy: Association of the therapeutic effect with differentiation and apoptosis in the cancer cells. Apoptosis 2: 227-238, 1997.
20. Kawai K, Konishi Y, Izumi K, Sato M, Adachi M and Hozumi M: Enhancement of anticancer effects of radiation and conventional anticancer agents by a quinolinone derivative, vesnarinone: Studies on human gastric cancer tissue xenografts in nude mice. Anticancer Res 18: 405-412, 1998.
21. Lamon EW, Gatti RA, Kiessling R and Fenyo EM: Comparison of the allospecific and viral-specific immune responses to irradiated versus formaldehyde-fixed allogeneic Molony lymphoma cells in CBA mice. Cancer Res 35: 962-969, 1975.
22. Dong Z, Qi Z, Xie K and Fidler IJ: Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in LPS-responsive and LPS-nonresponsive murine macrophages. J Immunol 151: 2717-2724, 1993.
23. Schmidt HHHW, Warner TD, Nakane M, Forstermann U and Murad F: Regulation and subcellular location of nitrogen oxide synthase in RAW264.7 macrophages. Mol Pharmacol 41: 615-624, 1992.
24. Steuhr DJ, Kwon NS, Gross SS, Thiel BA, Levi R and Nathan CF: Synthesis of nitrogen oxide from L-arginine by macrophage cytosol: requirement for inducible and constitutive components. Biochem Biophys Res Commun 161: 420-426, 1990.
25. Böyum A: Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Invest 21: 77-89, 1967.
26. Timonen T and Saksela E: A simplified isotope release assay for cell-mediated cytotoxicity against anchorage-dependent target cells. J Immunol Meth 18: 123-32, 1977.
27. Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction. Anal Biochem 162: 156-159, 1987.
28. Okamoto M, Oshikawa T, Ohe G, Nishikawa H, Furuichi S, Tano T, Moriya Y, Saito M and Sato M: Severe impairment of anti-cancer effect of lipoteichoic acid-related molecule isolated from a penicillin-killed Streptococcus pyogenes in toll-like receptor 4-deficient mice. Int Immunopharmacol 1: 1789-1795, 2001.
29. Chow JC, Young DW, Golenbock DT, Christ WJ and Gusovsky F: Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274: 10689-10692, 1999.
30. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K and Akira S: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product. J Immunol 162: 3749-3752, 1999.
31. Aderem A and Ulevitch JR: Toll-like receptors in the induction of the innate immune response. Nature 406: 782-787, 2000.
32. Limin L, Kilbourn RG, Adams J and Fidler IJ: Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells. Cancer Res 51: 2531-2535, 1991.
33. Xie K, Huan GS, Dong Z, Juang SH, Gutman M, Xie QW, Nathan C and Fidler IJ: Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J Exp Med. 181: 1333-1343, 1995.
34. Xie K, Huang S, Dong Z, Juang SH, Wang Y and Fidler IJ: Destruction of bystander cells by tumor cells transfected with inducible nitric oxide (NO) synthase gene. J Natl Cancer Inst 89: 421-427, 1997.
35. Schirrmacher V, Bai L, Umansky V, Yu L, Xing Y and Qian Z: Newcastle disease virus activates macrophages for anti-tumor activity. Int J Oncol 16: 363-373, 2000.
36. Yu WG, Ogawa M, Mu J, Umehara K, Tsujimura T, Fujiwara H and Hamaoka T: IL-12-induced tumor regression correlates with in situ activity of IFN-gamma produced by tumor-infiltrating cells and its secondary induction of anti-tumor pathways. J Leukoc Biol 62: 450-457, 1997.
37. Li N and Karin M: Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms. Proc Natl Acad Sci USA 95: 13012-13017, 1998.
38. Ghosh S: Regulation of inducible gene expression by the transcription factor NF-kappaB. Immunol Res 19: 183-189, 1999.
39. Hallaham DE, Spriggs DR, Beckett MA, Kufe DW, Weichselbaum RR: Increased tumor necrosis factor mRNA after cellular exposure to ionizing radiation. Proc Natl Acad Sci USA 86: 10104-10107, 1989.
40. Sherman ML, Datta R, Hallaham DE, Weichselbaum RR and Kufe DW: Regulation of tumor necrosis factor gene expression by ionizing radiation in human myeloid leukemia cells and peripheral blood monocyte. J Clin Invest 87: 1794-1797, 1991.
41. Brach MA, Grup HJ, Kaisho T, Asano Y, Hirano T and Hermann F: Ionizing radiation induces expression of interleukin 6 by human fibroblasts involving activation of nuclear factor-B. J Biol Chem 268: 8466-8472, 1993.
42. Abo T: Extrathymic pathways of T-cell differentiation: a primitive and fundamental immune systeme. Microbiol Immunol 37: 247-258, 1993.
43. Boileau C, Houde M, Dulude G, Clegg CH and Perreault C: Regulation of extrathymic T cell development and turnover by oncostatin M. J Immunol 164: 5713-5120, 2000.