Genomic structure and organization of kringles type 3 to 10 of the apolipoprotein (a) gene in 6q26-27

Gene

Volumn 196, Issue 1-2, 1997, Pages 1-8

  Mihalich, A ^a   Magnaghi, P ^a   Sessa, L ^a   Trubia, M ^a   Acquati, F ^a   Taramelli, R ^b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

Author keywords

Atherosclerosis; Evolution; Gene families; Thrombosis

Indexed keywords

APOLIPOPROTEIN A;

ARTICLE; CHROMOSOME 6Q; EVOLUTION; GENE; GENE MAPPING; GENE STRUCTURE; GENETIC POLYMORPHISM; HUMAN; KRINGLE DOMAIN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION MAPPING; SEQUENCE ANALYSIS;

APOLIPOPROTEINS A; BACTERIOPHAGES; CHROMOSOMES, ARTIFICIAL, YEAST; CHROMOSOMES, HUMAN, PAIR 6; CLONING, MOLECULAR; COSMIDS; EXONS; GENE AMPLIFICATION; HUMANS; INTRONS; KRINGLES; POLYMERASE CHAIN REACTION; RESTRICTION MAPPING;

EID: 0030852316     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(97)00091-7     Document Type: Article

References (27)

1. Boerwinkle, L., Menzel, H.J., Kraft, H.G., Utermann, G., 1989. Genetics of the quantitative Lp(a) lipoprotein trait. III. Contribution of Lp(a) glycoprotein phenotypes to normal lipid variation. Hum. Genet. 82, 73-78.
2. Boerwinkle, E., Leffert, C.C., Un, J., Lackner, C., Chiesa, G., Hobbs, H.H., 1992. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J. Clin. Invest. 90, 52-60.
3. Bopp, S., Köchl, S., Acquati, F., Magnaghi, P., Pethö-Schramm, A., Kraft, H.G., Utermann, G., Muller, H.J., Taramelli, R., 1995. Ten allelic apolipoprotein(a) 5′ flanking fragments exhibit comparable promoter activities in HepG2 cells. J. Lipid Res. 36, 1721-1728.
4. Byrne, C.D., Schwartz, K., Meer, K., Cheng, J.F., Lawn, R.M., 1994. The human apolipoprotein(a)/plasminogen gene cluster contains a novel homologue transcribed in liver. Arterioscler. Thromb. 14, 534-541.
5. Cohen, J.C., Chiesa, G., Hobbs, H.H., 1993. Sequence polymorphisms in the apolipoprotein(a) gene. J. Clin. Invest. 91, 1630-1636.
6. Ernst, A., Helmhold, M., Brunner, C., Armstrong, V.W., Muller, H.J., 1995. Identification of two functionally distinct lysine-binding sites in kringle 37 in kringles 32-36 of human apolipoprotein(a). J. Biol. Chem. 270, 6227-6234.
7. Frank, S., Durovic, S., Kostner, G.M., 1994. Structural requirements of apo(a) for the lipoprotein(a) assembly. Biochem. J. 304, 27-30.
8. Frazer, K., Narla, G., Zhang, J., Rubin, E., 1995. The apolipoprotein (a) gene is regulated by sex hormones acute-phase inducers in YAC transgenic mice. Nature Genet. 9, 424-430.
9. Guevara, G., Jan, A.Y., Knapp, R., Tulinsky, A., Morriset, J.D., 1993. Comparison of lig-binding sites of modeled apo(a) kringle-like sequences in human lipoprotein(a). Arterioscler. Thromb. 13, 758-770.
10. Kraft, H.G., Kochl, S., Menzel, H.J., Sholzer, C., Utermann, G., 1992. The apolipoprotein(a) gene: a transcribed hypervariable locus controlling plasma lipoprotein(a) concentration. Hum. Genet. 90, 220-230.
11. Lackner, C., Boerwinkle, E., Leffert, C.C., Rahmig, T., Hobbs, H.H., 1991. Molecular basis of apolipoprotein(a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis. J. Clin. Invest. 87, 2153-2161.
12. Lackner, C., Cohen, J.C., Hobbs, H.H., 1993. Molecular definition of the extreme size polymorphism in apolipoprotein(a). Hum. Mol. Genet. 2, 933-940.
13. Magnaghi, P., Citterio, E., Malgaretti, N., Acquati, F., Ottolenghi, S., Taramelli, R., 1994. Molecular characterization of the human apo(a)plasminogen gene family clustered on the telomeric region of chromosome 6 (6q26-27). Hum. Mol. Genet. 3, 437-442.
14. Magnaghi, P., Mihalich, A., Taramelli, R., 1994. Several liver specific DNAse hypersensitive sites are present in the intergenic region separating human plasminogen apopoprotein(a) genes. Biochem. Biophys. Res. Commun. 205, 930-935.
15. Malgaretti, N., Acquati, F., Magnaghi, P., Bruno, L., Pontoglio, M., Rocchi, M., Saccone, S., Della Valle, G., D'Urso, M., Le Paslier, D., Ottolenghi, S., Taramelli, R., 1992. Characterization by yeast artificial chromosome cloning of the linked apolipoprotein(a) and plasminogen genes and identification of the apolipoprotein(a) flanking region. Proc. Natl. Acad. Sci. USA 89, 11584-11588.
16. Mancini, F.P., Mooser, V., Guerra, R., Hobbs, H.H., 1995. Sequence microheterogeneity in apolipoprotein(a) gene repeats and the relationship to plasma Lp(a) levels. Hum. Mol. Genet. 4, 1535-1542.
17. McLean, J.W., Tomlinson, J.E., Kuang, W.J., Eaton, D., , LChen, E.Y., Fless, G., Scanu, A.M., Lawn, R.M., 1987. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature 330, 132-137.
18. Meroni, G., Buraggi, G., Mantovani, R., Taramelli, R., 1996. HNF-1 and AP3-like motif mediate the tissue specificity of the human plasminogen gene. Eur. J. Biochem. 236, 373-382.
19. Mooser, V., Mancini, F.P., Bopp, S., Pethö-Schramm, A., Guevara, R., Boerwinkle, E., Muller, H.J., Hobbs, H.H., 1995. Sequence polymorphism in the apo(a) gene associated with specific levels of Lp(a) in plasma. Hum. Mol. Genet. 4, 173-181.
20. Perombelon, N., Soutar, A.K., Knight, B., , L1994. Variation in lipoprotein(a) concentration associated with different apolipoprotein(a) alleles. J. Clin. Invest. 93, 1481-1492.
21. Pesole, G., Gerardi, A., Di Jeso, F., Saccone, C., 1994. The peculiar evolution of apolipoprotein(a) in human and rhesus macaque. Genetics 136, 255-260.
22. Sanger, P., Nicklen, S., Coulson, A.R., 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463-5467.
23. Tomlinson, J.E., Mc Lean, J.W., Lawn, R.M., 1989. Rhesus monkey apolipoprotein(a) sequence, evolution and sites of synthesis. J. Biol. Chem. 264, 5957-5965.
24. Trommsdorff, M., Köchl, S., Lingenhel, A., Kronenberg, F., Delport, R., Vermaak, H., Lemming, L., Klausen, I.C., Faergeman, O., Utermann, G., Kraff, H.G., 1995. A pentanucleotide repeat polymorphism in the 5′ control region of the apolipoprotein(a) gene is associated with lipoprotein(a) plasma concentration in Caucasians. J. Clin. Invest. 96, 150-157.
25. Utermann, G., 1989. The mysteries of lipoprotein(a). Science 246, 904-910.
26. Van der Hoek, Y.Y., Wittekoek, M.E., Beisiegel, U., Kastelein, J.P.J., Koschinsky, M.L., 1993. The apolipoprotein(a) kringle IV repeats which differ from the major repeat kringle are present in variably-sized isoforms. Hum. Mol. Genet. 2, 361-366.
27. Wade, D., Clarke, J.G., Lindahl, G.E., Liu, A.C., Zysow, K., Meer, K., Schwartz, K., Lawn, R.M., 1993. 5′ control regions of the apolipoprotein(a)gene and members of the related plasminogen gene family. Proc. Natl. Acad. Sci. USA 90, 1369-1373.