Development of an atropselective methodology for axially chiral biaryls in the asymmetric synthesis of A-240610.0

Current Opinion in Drug Discovery and Development

Volumn 5, Issue 6, 2002, Pages 852-859

  Ku, Yi Yin ^a   Grieme, Tim ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Asymmetric synthesis; Atropisomeric control of axial chirality; Atropselective synthesis; Axial chiral biaryl; Axial chirality

Indexed keywords

2 PROPANOL; A 240610.0; ALLYL ALCOHOL; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; LACTONE; PREDNISOLONE; UNCLASSIFIED DRUG;

CHEMICAL REACTION; CHEMISTRY; CHIRALITY; CHRONIC INFLAMMATION; CYCLIZATION; DRUG EFFICACY; DRUG ISOLATION; DRUG PURIFICATION; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; GLUCOSE INTOLERANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROGENATION; IN VIVO STUDY; ISOMER; MITSUNOBU REACTION; OSTEOPOROSIS; PROCESS DEVELOPMENT; RACEMIC MIXTURE; REVIEW; SCALE UP; STEREOCHEMISTRY; TECHNIQUE;

ANIMALS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; STEREOISOMERISM; TECHNOLOGY, PHARMACEUTICAL;

EID: 0036868292     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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