Comparative studies on extracellular protease secretion and glucoamylase production by free and immobilized Aspergillus niger cultures

Journal of Industrial Microbiology and Biotechnology

Volumn 29, Issue 5, 2002, Pages 259-263

  Papagianni, Maria ^a,b   Joshi, N ^a   Moo Young, M ^a  

^a Ohio University   (United States)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Aspergillus niger; Celite; Cell immobilization; Glucoamylase; Proteases

Indexed keywords

FUNGAL ENZYME; GLUCAN 1,4 ALPHA GLUCOSIDASE; PROTEINASE;

ARTICLE; ASPERGILLUS NIGER; BIOREACTOR; CELL ADHESION; CELL FREE SYSTEM; COMPARATIVE STUDY; ENZYME RELEASE; FUNGUS CULTURE; IMMOBILIZED CELL; MYCELIUM; NONHUMAN;

ASPERGILLUS NIGER; BIOREACTORS; ENDOPEPTIDASES; GLUCAN 1,4-ALPHA-GLUCOSIDASE; INDUSTRIAL MICROBIOLOGY;

ASPERGILLUS; ASPERGILLUS NIGER; FUNGI;

EID: 0036853060     PISSN: 13675435     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jim.7000289     Document Type: Article

References (29)

1. Araujo MLGC, RP Oliveira, RC Giordano and CO Hokka. 1996. Comparative studies on cephalosporin C production process with free and immobilized cells of Cephalosporium acremonium ATCC 48272. Chem Eng Sci 51: 2835-2840.
2. Basso A, L Martin, C Ebert, L Gardossi and P Linda. 2000. Controlling the hydration of covalently immobilized penicillin G amidase in low-water medium: Properties and use of Celite R-640. J Mol Catal B Enzym 8: 245-253.
3. Berka RM, M Ward, LJ Wilson, KJ Hayenga, KH Kodama, LP Carlomagno and SA Thomson. 1990. Molecular cloning and deletion of the aspergillopepsin A gene from Aspergillus awamori. Gene 86: 153-162.
4. Braun S and SE Vecht-Lifshitz. 1991. Mycelial morphology and metabolite production. TIBTECH 9: 63-68.
5. Chun GT and SN Agathos. 1991. Comparative studies of physiological and environmental effects on the production of cyclosporin A in suspended and immobilized cells of Tolypocladium inflatum. Biotechnol Bioeng 37: 256-265.
6. Chun GT and SN Agathos. 1993. Dynamic response of immobilized cells to pulse addition of L-valine in cyclosporin A biosynthesis. J Biotechnol 27: 283-294.
7. Costerton JW, KJ Cheng, GG Geesey, TI Lodd, JC Nickel, M Dasupta and TJ Marrie. 1987. Bacterial biofilms in nature and disease. Annu Rev Microbiol 41: 435-467.
8. Gbewonyo K and D Wang. 1983. Confining mycelial growth to porous microbeads: A novel technique to alter the morphology of non-Newtonian mycelial cultures. Biotechnol Bioeng 25: 967-983.
9. Gikas P and AG Livingston. 1997. Specific ATP and specific oxygen uptake rate in immobilized cell aggregates: Experimental and theoretical analysis using a structured model of immobilized cell growth. Biotechnol Bioeng 55(4): 660-673.
10. Gouka RJ, PJ Punt and JGM Hessing. 1996. Analysis of heterologous protein production in defined recombinant Aspergillus awamori strains. Appl Environ Microbiol 62: 1951-1957.
11. Gouka RJ, PJ Punt and CAMJJ van den Hondel. 1997. Efficient production of secreted proteins by Aspergillus: Progress, limitations and prospects. Appl Microbiol Biotechnol 47: 1-11.
12. Gwynne D and M Devchand. 1992. Expression of foreign proteins in the genus Aspergillus. In: Bennett JW and MA Klich (Eds), Aspergillus: Biology and Industrial Applications. Butterworth Heinemann, Boston, MA, pp. 202-214.
13. Jirku V. 1992. Permeabilization of covalently immobilized Saccharomyces cerevisiae. Acta Biotechnol 12: 333-336.
14. Jirku V. 1996. The use of covalently immobilized mycelia to modify the b-glucanase system of Aspergillus vesicolor. J Chem Technol Biotechnol 65: 179-185.
15. Jirku V. 1997. Changes in the starvation response through covalent cell attachment. Antonie van Leeuwenhoek 71: 369-373.
16. Laca A, C Quiros, LA Garcia and M Diaz. 1998. Modelling and description of internal profiles in immobilized cell systems. Biochem Eng J 1: 225-232.
17. Lee TH, GT Chun and YK Chang. 1997. Development of sporulation/immobilization method and its application for the continuous production of cyclosporin A by Tolypocladium inflatum. Biotechnol Prog 13: 546-550.
18. Lin W, RS Feldberg and E Clark. 1993. Kinetics of cell growth and heterologous glucoamylase production in recombinant Aspergillus nidulans. Biotechnol Bioeng 41: 273-279.
19. Mattern IE, JM van Noort, P Berg, DB Archer, IN Roberts and CAMJJ van den Hondel. 1992. Isolation and characterization of mutants of Aspergillus niger deficient in extracellular proteases. Mol Gen Genet 234: 332-336.
20. Papagianni M. 1995. Morphology and Citric Acid Production in Aspergillus niger Submerged Fermentation. PhD thesis. University of Strathclyde, Glasgow, UK.
21. Papagianni M. 1999. Fungal morphology. In: Kristiansen B, M Mattey and J Linden (Eds), Citric Acid Biotechnology. Taylor and Francis, London, pp. 69-84.
22. Papagianni M and M Moo-Young. 2002. Protease secretion in glucoamylase producer Aspergillus niger cultures: Fungal morphology and inoculum effects. Process Biochem 37: 1271-1278.
23. Schügerl K, SR Gerlach and D Siedenberg. 1997. Influence of the process parameters on the morphology and enzyme production of Aspergilli. Adv Biochem Eng Biotechnol 60: 195-267.
24. Shuler ML and F Kargi. 1992. Bioprocess Engineering. Prentice Hall, NJ.
25. van den Homberg JPTW, PJI van de Vondervoort, NCBA van der Heijden and J Visser 1995. New protease mutants in Aspergillus niger result in strongly reduced in vitro degradation of target proteins; genetical and biochemical characterization of seven complementation groups. Curr Genet 28: 299-308.
26. van den Homberg JPTW, PJI van de Vondervoort, L Fraissinet-Tachet and J Visser. 1997. Aspergillus as a host for heterologous protein production: The problem of proteases. TIBTECH 15: 256-263.
27. van Suijdam JC, NWF Kossen and PG Paul. 1980. An inoculum technique for the production of fungal pellets. Eur J Appl Microbiol Biotechnol 10: 211-221.
28. Willaert RG, GV Baron and L De Backer. 1996. Immobilized Living Cell Systems. Wiley, Chichester.
29. Wittler R, H Baumgardi, DW Lübbers and K Schügerl. 1986. Investigations of oxygen transfer into Penicillium chysogenum pellets by microprobe measurements. Biotechnol Bioeng 28: 1024-1036.