Virulence factor expression by Gram-positive cocci exposed to subinhibitory concentrations of linezolid

Journal of Antimicrobial Chemotherapy

Volumn 50, Issue 5, 2002, Pages 665-672

  Gemmell, Curtis G ^a   Ford, Charles W ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE DERIVATIVE; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; CLINDAMYCIN; COAGULASE; DEOXYRIBONUCLEASE; ERYTHROMYCIN; GLYCOPEPTIDE; HEMOLYSIN; LINEZOLID; M PROTEIN; METICILLIN; OXAZOLIDINONE DERIVATIVE; PROTEIN A; STREPTOLYSIN O; VIRULENCE FACTOR; ACETAMIDE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL INFECTION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOLYSIS; DRUG EFFECT; DRUG EFFICACY; ERYTHROCYTE; GRAM POSITIVE BACTERIUM; GRAM POSITIVE COCCI; ISOTOPE LABELING; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION; STAPHYLOCOCCUS AUREUS; STRAIN DIFFERENCE; STREPTOCOCCUS PYOGENES; TRANSLATION REGULATION; BIOSYNTHESIS; COMPARATIVE STUDY; HUMAN; METABOLISM; MICROBIOLOGY; PHAGOCYTE;

STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES;

ACETAMIDES; GRAM-POSITIVE COCCI; HUMANS; OXAZOLIDINONES; PHAGOCYTES; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; VIRULENCE FACTORS;

EID: 0036850669     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkf192     Document Type: Article

References (27)

1. Archer, G. L. (1998). Staphylococcus aureus: a well-armed pathogen. Clinical Infectious Diseases 26, 1179-81.
2. Schmitt, C. K., Meysick, K. C. & O'Brien, A. D. (1999). Bacterial toxins: friends or foes? Emerging Infectious Diseases 5, 224-34.
3. Ohlsen, K., Koller, K-P. & Hacker, J. (1997). Analysis of expression of the alpha-toxin gene (hla) of Staphylococcus aureus by using a chromosomally encoded hla::lacZ gene fusion. Infection and Immunity 65, 3606-14.
4. Ohlsen, K., Ziebuhr, W., Koller, K.-P., Hell, W., Wichelhaus, T. A. & Hacker, J. (1998). Effects of subinhibitory concentrations of antibiotics on alpha-toxin (hla) gene expression of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates. Antimicrobial Agents and Chemotherapy 42, 2817-23.
5. Forsgren, A. (1970). Significance of protein A production by staphylococci. Infection and Immunity 2, 672-3.
6. Nilsson, I.-M., Hartford, O., Foster, T. & Tarkowski, A. (1999). Alpha-toxin and gamma-toxin jointly promote Staphylococcus aureus virulence in murine septic arthritis. Infection and Immunity 67, 1045-9.
7. Patel, A. H., Nowlan, P., Weavers, E. D. & Foster, T. (1987). Virulence of protein A-deficient and alpha-toxin-deficient mutants of Staphylococcus aureus isolated by allele replacement. Infection and Immunity 55, 3103-10.
8. Bisno, A. L. & Stevens, D. L. (1996). Streptococcal infections of skin and soft tissue. New England Journal of Medicine 334, 240-5.
9. Widdowson, J. P., Maxted, W. R., Notley, C. M. & Pinney, A. M. (1974). The antibody responses in man to infection with different serotypes of group A streptococci. Journal of Medical Microbiology 7, 483-96.
10. Chaussee, M. S., Liu, J., Stevens, D. L. & Ferretti, J. J. (1997). Effects of environmental factors on streptococcal erythrogenic toxin A (SPEA) production by Streptococcus pyogenes. Advances in Experimental Medicine and Biology 418, 551-4.
11. Gemmell, C. G. (1984). Clindamycin and its action on the susceptibility of pathogenic bacteria to phagocytosis. Scandinavian Journal of Infectious Diseases 43, Suppl., 17-23.
12. Gemmell, C. G. (1995). Antibiotics and the expression of staphylococcal virulence. Journal of Antimicrobial Chemotherapy 36, 283-91.
13. Gemmell, C. G., Goutcher, S. C., Reid, R. & Sturrock, R. D. (1997). Role of certain virulence factors in a murine model of Staphylococcus aureus arthritis. Journal of Medical Microbiology 46, 208-13.
14. Stevens, D. L. (1999). The flesh eating bacterium: what's next? Journal of Infectious Diseases 179, Suppl. 2, S366-74.
15. Stevens, D. L. & Bryant, A. E. (1997). Streptolysin O modulates cytokine synthesis in human peripheral blood mononuclear cells. Advances in Experimental Medicine and Biology 418, 925-7.
16. Gemmell, C. G., Peterson, P. K., Schmeling, D., Kim, Y., Mathews, J., Wannamaker, L. et al. (1981). Potentiation of opsonization and phagocytosis of Streptococcus pyogenes following growth in the presence of clindamycin. Journal of Clinical Investigation 67, 1249-56.
17. Gemmell, C. G., Peterson, P. K., Schmeling, D. & Quie, P. G. (1982). Studies on the potentiation of phagocytosis of Streptococcus pyogenes by treatment with various antibiotics. Drugs Under Experimental and Clinical Research 8, 235-40.
18. Gemmell, C. G. & Shibl, A. (1976). The control of toxin and enzyme biosynthesis in staphylococci by antibiotics. In International Symposium on Staphylococci and Staphylococcal Infections, 3rd edn (Jeljaszewicz, J., Ed.), pp. 657-64. Gustav Fischer, Stuttgart, Germany.
19. Herbert, S., Barry, P. & Novick, R. D. (2001). Subinhibitory clindamycin inhibits transcription of exoprotein genes in Staphylococcus aureus. Infection and Immunity 69, 2996-3003.
20. Bernheimer, A. W. & Schwartz, L. L. (1963). Isolation and composition of staphylococcal alpha-toxin. Journal of General Microbiology 30, 455-68.
21. Stevens, D. L., Madaras-Kelly, K. J. & Richards, D. M. (1998). In vitro antimicrobial effects of various combinations of penicillin and clindamycin against four strains of Streptococcus pyogenes. Antimicrobial Agents and Chemotherapy 42, 1266-8.
22. Verdrengh, M., Springer, T. A., Gutierrez-Ramos, J. C. & Tarkowski, A. (1996). Role of intercellular adhesion molecule 1 in pathogenesis of staphylococcal arthritis and in host defense against staphylococcal bacteremia. Infection and Immunity 64, 2804-7.
23. Hiramatsu, K., Aritaka, N., Hanaki, H., Kawasaki, S., Hosoda, Y., Hori, S. et al. (1997). Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin. Lancet 350, 1670-3.
24. Livermore, D. M. (2000). Antibiotic resistance in staphylococci. International Journal of Antimicrobial Agents 16, Suppl. 1, S3-10.
25. Stevens, D. L., Smith, L. G., Bruss, J. B., McConnell-Martin, M. A., Duvall, S. E., Todd, W. M. et al. (2000). Randomized comparison of linezolid (PNU-100766) versus oxacillin-dicloxacillin for treatment of complicated skin and soft tissue infections. Antimicrobial Agents and Chemotherapy 44, 3408-13.
26. Stevens, D. L., Bryant, A. E. & Hackett, S. P. (1995). Antibiotic effects on bacterial viability, toxin production, and host response. Clinical Infectious Diseases 20, S154-7.
27. Stevens, D. L., Maier, K. A. & Mitten, J. E. (1987). Effect of antibiotics on toxin production and viability of Clostridium perfringens. Antimicrobial Agents and Chemotherapy 31, 213-8.