Biological effectiveness of isolated short electron tracks: V79-4 cell inactivation following low dose-rate irradiation with AlK ultrasoft X-rays

International Journal of Radiation Biology

Volumn 78, Issue 11, 2002, Pages 967-979

  Hill, M A ^a   Stevens, D L ^a   Bance, D A ^a   Goodhead, D T ^a  

^a MRC Radiat and Genome Stability U   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT 60; DNA;

ANIMAL CELL; ARTICLE; CONFOCAL LASER MICROSCOPY; DNA DAMAGE; DNA STRAND BREAKAGE; DOSIMETRY; ELECTRON; GAMMA IRRADIATION; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; X IRRADIATION; X RAY;

ALUMINUM; ANIMALS; CELL CYCLE; CELL LINE; CELL SIZE; CELL SURVIVAL; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRONS; FIBROBLASTS; LINEAR ENERGY TRANSFER; MICROSCOPY, CONFOCAL; POISSON DISTRIBUTION; RADIATION DOSAGE; RELATIVE BIOLOGICAL EFFECTIVENESS; TIME FACTORS; X-RAYS;

ANIMALIA; MAMMALIA;

EID: 0036850381     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/0955300021000016350     Document Type: Article

References (38)

1. Botchway, S. W., Stevens, D. L., Hill, M. A., Jenner, T. J. and O'Neill, P., 1997, Induction and rejoining of DNA double strand breaks in Chinese hamster V79-4 cells with characteristic aluminum K and copper L ultrasoft x-rays. Radiation Research, 148, 317-324.
2. Brenner, D. J., Bird, R. P., Zaider, M., Goldhagen, P., Kliaga, P. J. and Rossi, H. H., 1987, Inactivation of synchronised mammalian cells with low energy X-rays - Results and significance. Radiation Research, 110, 413-427.
3. Cucinotta, F. A., Nikjoo, H., O'Neill, P. and Goodhead, D. T., 2000, Kinetics of DSB rejoining and formation of simple chromosome exchange aberrations. International Journal of Radiation Biology, 76, 1463-1474.
4. DeLara, C. M., Hill, M. A., Jenner, T. J., Papworth, D. and O'Neill, P., 2001, Dependence of the yields on DNA double-strand breaks in Chinese hamster V79-4 cells on the photon energy of ultrasoft x rays. Radiation Research, 155, 440-448.
5. Folkard, M., Vojnovic, B., Prise, K. M. and Michael, B. D., 1987, An arrangement for irradiating cultured mammalian cells with low energy ultrasoft X-rays. Physics in Medicine and Biology, 32, 1615-1626.
6. Frankenberg, D., Kühn, H., Frankenberg-Schwager, M., Lenhard, W. and Beckonert, S., 1995, 0.3 keV carbon K ultrasoft X-rays are four rimes more effective than γ-rays when inducing oncogenic cell transformation at low doses. International Journal of Radiation Biology, 6, 593-601.
7. Goodhead, D. T., 1982, An assessment of the role of microdosimetry in radiobiology. Radiation Research, 91, 45-76.
8. Goodhead, D. T., 1985, Saturable repair models of radiation action in mammalian-cells. Radiation Research, 104, S58-S67.
9. Goodhead, D. T., 1992, Biophysical modelling in radiation protection. In K. H. Chadwick, G. Moschini and M. N. Varma (eds), Biophysical Modeling of Radiation Effects (Philadelphia: Adam Hilger), pp. 113-124.
10. Goodhead, D. T., 1994a, Soft x-ray radiobiology and synchrotron radiation. In Synchrotron Radiation in Biosciencies (Oxford: Oxford University Press), pp. 683-705.
11. Goodhead, D. T., 1994b, Initial events in the cellular effects of ionizing radiations: Clustered damage in DNA. International Journal of Radiation Biology, 65, 7-17.
12. Goodhead, D. T., Bance, D. A., Stretch, A. and Wilkinson, R. E., 1991, A versatile Pu-238 irradiator for radiobiological studies with alpha-particles. International Journal of Radiation Biology, 59, 195-210.
13. Goodhead, D. T. and Nikjoo, H., 1990, Current status of ultrasoft x-rays and track structure analysis as tools for testing and developing biophysical models of radiation action. Radiation Protection Dosimetry, 31, 343-350.
14. Goodhead, D. T. and Thacker, J., 1977, Inactivation and mutation of cultured mammalian cells by aluminium characteristic ultrasoft X-rays I. Properties of aluminium X-rays and preliminary experiments with Chinese hamster cells. International Journal of Radiation Biology, 31, 541-559.
15. Goodhead, D. T., Thacker, J. and Cox, R., 1981, Is selective absorption of ultrasoft x-rays biologically important in mammalian cell? Physics in Medicine and Biology, 96, 1115-1127.
16. Griffin, C. S., Hill, M. A., Papworth, D. G., Townsend, K. M. S., Savage, J. R. K. and Goodhead, D. T., 1998, Effectiveness of 0.28 keV carbon K ultrasoft X-rays at producing simple and complex chromosome exchanges in human fibroblasts in vitro detected using FISH. International Journal of Radiation Biology, 73, 591-598.
17. Hahn, G. M. and Little, J. B., 1972, Plateau-phase cultures of mammalian cells: An in vitro model for human cancer. Current Topics in Radiation Research, 8, 39-83.
18. Henke, M., Gullikson, E. M. and Davis, J. C., 1993, X-ray interactions: Photoabsorption, scattering, transmission and reflection at E=50-30 000 eV, Z=1-92. Atomic Data and Nuclear Data Tables, 54, 181-342.
19. Hill, M. A., Stevens, D. L., Bance, D. A. and Goodhead, D. T., 1997, A versatile mammalian cell irradiation rig for low dose rate ultrasoft x-ray studies. In Microdosimetry an Interdisciplinary Approach (London: Royal Society of Chemistry), pp. 203-206.
20. Hill, M. A., Stevens, D. L., Townsend, K. M. S. and Goodhead, D. T., 2001, Comments on the recently reported low biological effectiveness of ultrasoft x rays. Radiation Research, 155, 503-510.
21. Hill, M. A., Vecchia, M. D., Townsend, K. M. S. and Goodhead, D. T., 1998, Production and dosimetry of copper L ultrasoft x-rays for biological and biochemical investigations. Physics in Medicine and Biology, 43, 351-363.
22. Hoshi, M., Goodhead, D. T., Brenner, D. J., Bance, D. A., Chmielewski, J. J., Paciotti, M. A. and Bradbury, J. N., 1980, Dosimetry comparison and characterisation of an Al K ultrasoft x-ray beam from an MRC cold-cathode source. Physics in Medicine and Biology, 30, 1029-1041.
23. ICRP, 1975, Reference man: Anatomical, physiological and metabolic characteristics. ICRP Publication 23 (Oxford: Pergamon).
24. Kellerer, A. M. and Rossi, H. H., 1978, A generalized formulation of dual radiation action. Radiation Research, 75, 471-488.
25. McCullagh, P. and Nelder, J. A., 1989, Generalized Linear Models (London: Chapman & Hall).
26. Meger Wells, C. M., Pearson, D. W., Deluca, P. M., Jr, Wells, G. M., Cerrina, F., Kennan, W. S. and Gould, M. N., 1991, Synchrotron-produced ultrasoft x-rays: A tool for investigating biophysical models of radiation action. International Journal of Radiation Biology, 59, 985-996.
27. Mitchell, J. B., Bedford, J. S. and Bailey, S. M., 1979a, Dose-rate effects in plateau-phase cultures of S3 HeLa and V79 cells. Radiation Research, 79, 552-567.
28. Mitchell, J. B., Bedford, J. S. and Bailey, S. M., 1979b, Dose-rate effects on the cell cycles and survival of S3 and V79 cells. Radiation Research, 79, 520-536.
29. Neary, G. J., 1970, Irradiation of simple biological specimens by charged particles. In The Uses of Cyclotrons in Chemistry, Metallurgy and Biology (London: Butterworth), pp. 194-203.
30. Nikjoo, H. and Goodhead, D. T., 1991, Track structure analysis illustrating the prominent role of low energy electrons in radiobiological effects of low-LET radiations. Physics in Medicine and Biology, 36, 229-238.
31. Nikjoo, H., O'Neill, P., Goodhead, D. T. and Terrissol, M., 1997, Computational modelling of low-energy electron-induced DNA damage by early physical and chemical events. International Journal of Radiation Biology, 71, 467-483.
32. Ottolengehi, A., Merzagora, M. and Paretzke, H. G., 1997, DNA complex lesions induced by protons and α-particles: Track structure characteristics determining linear energy transfer and particle type dependence. Radiation and Environmental Biophysics, 36, 97-103.
33. Pretlow, T. G., Weir, E. E. and Zettergren, J. G., 1975, Problems connected with separation of different kinds of cells. International Review of Experimental Pathology, 14, 91-204.
34. Raju, M. R., Carpenters, S. G., Chmielewski, J. J., Schillaci, M. E., Wilder, M. E., Freyer, J. P., Johnson, N. F., Schor, P. L., Sebring, R. J. and Goodhead, D. T., 1987, Radiobiology of ultrasoft X rays I. Cultured hamster cells (V79). Radiation Research, 110, 396-412.
35. Raju, M. R., Schillaci, M. E., Carpenter, S. G., Goodhead, D. T. and Ward, J. F., 1996, Radiobiology of ultrasoft x rays. V. Modification of cell inactivation by dimethyl sulfoxide. Radiation Research, 145, 563-567.
36. Thacker, J. and Stretch, A., 1983, Recovery from lethal and mutagenic damage during postirradiation holding and low-dose-rate irradiations of cultured hamster cells. Radiation Research, 96, 380-392.
37. Townsend, K. M. S. and Marsden, S. J., 1992, Nuclear area measurements on viable cells, using confocal microscopy. International Journal of Radiation Biology, 61, 549-551.
38. Townsend, K. M. S., Stretch, A., Stevens, D. L. and Goodhead, D. T., 1990, Thickness measurements on V79-4 cells: A comparison between laser scanning confocal microscopy and electron microscopy. International Journal of Radiation Biology, 38, 545-557.