Effects of histamine H2-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide

Journal of Pharmacy and Pharmacology

Volumn 54, Issue 11, 2002, Pages 1559-1563

  Itoh, Hiroki ^a   Naito, Takafumi ^a   Takeyama, Masaharu ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CIMETIDINE; FAMOTIDINE; GASTROINTESTINAL POLYPEPTIDE; HISTAMINE H2 RECEPTOR ANTAGONIST; LACTOSE; NIZATIDINE; PLACEBO; RANITIDINE; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; ENZYME IMMUNOASSAY; GASTROINTESTINAL TRACT; HUMAN; HUMAN EXPERIMENT; MALE; METABOLIC INHIBITION; METABOLIC REGULATION; NORMAL HUMAN; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN SECRETION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STOMACH ACID SECRETION; STOMACH MUCOSA BLOOD FLOW; STOMACH PROTECTION; VENOUS BLOOD; VOLUNTEER; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; TIME;

ADULT; CALCITONIN GENE-RELATED PEPTIDE; CIMETIDINE; FAMOTIDINE; HISTAMINE H2 ANTAGONISTS; HUMANS; MALE; NIZATIDINE; RANITIDINE; SUBSTANCE P; TIME FACTORS; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0036850169     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/002235702117     Document Type: Article

References (24)

1. Amara, S. G., Jonas, V., Rosenfeld, M. G., Ong, E. S., Evans, R. M. (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298: 240-244
2. Bauerfeind, P., Hof, R., Hof, A., Cucala, M., Siegrist, S., von Ritter, C., Fischer, J. A., Blum, A. L. (1989) Effects of hCGRP I and II on gastric blood flow and acid secretion in anesthetized rabbits. Am. J. Physiol. 256: G145-G149
3. Costa, M., Furness, J. B., Pullin, C. O., Bornstein, J. (1985) Substance P enteric neurons mediate non-cholinergic transmission to the circular muscle of the guinea-pig intestine. Naunyn Schmiedebergs Arch. Pharmacol. 328: 446-453
4. 2-receptor antagonists in peptic ulcer disease. Efficacy in healing peptic ulcers. Drugs 44: 709-719
5. Fahrenkrug, J. (1993) Transmitter role of vasoactive intestinal peptide. Pharmacol. Toxicol. 72: 354-363
6. Goyal, R. K., Rattan, S., Said, S. (1980) VIP as a possible neurotransmitter of non-cholinergic non-adrenergic inhibitory neurons. Nature 288: 378-380
7. Grider, J. R. (1989) Tachykinins as transmitters of ascending contractile component of the peristaltic reflex. Am. J. Physiol. 257: G709-G714
8. Grider, J. R., Cable, M. B., Bitar, K. N., Said, S. I., Makhlouf, G. M. (1985) Vasoactive intestinal peptide. Relaxant neurotransmitter in tenia coli of the guinea pig. Gastroenterology 89: 36-42
9. Gronbech, J. E., Lacy, E. R. (1994) Substance P attenuates gastric mucosal hyperemia after stimulation of sensory neurons in the rat stomach. Gastroenterology 106: 440-449
10. Hokfelt, T., Johansson, O., Kellerth, J. O., Ljungdahl, A., Nilsson, G., Nygards, A., Pernow, B. (1977) Immunohistochemical distribution of substance P. In: von Euler, U. S., Pernow, B. (eds) Substance P. Raven Press, New York, pp 117-145
11. Katsoulis, S., Conlon, J. M. (1989) Calcitonin gene-related peptides relax guinea pig and rat gastric smooth muscle. Eur. J. Pharmacol. 162: 129-134
12. Kitagawa, T., Shimozono, T., Aikawa, T., Yoshida, T., Nakamura, H. (1981) Preparation and characterization of hetero-bifunctional cross-linking reagents for protein modifications. Chem. Pharm. Bull. 29: 1130-1133
13. Konturek, S. J., Radecki, T., Brzozowski, T., Piastucki, I., Dembinska-Kiec, A., Zmuda, A. (1981) Gastric cytoprotection by prostaglandins, ranitidine, and probanthine in rats. Role of endogenous prostaglandins. Scand. J. Gastroenterol. 16: 7-12
14. Kwok, Y. N., McIntosh, C. H. S. (1990) Release of substance P-like immunoreactivity from the vascularly perfused rat stomach. Eur. J. Pharmacol. 180: 201-207
15. 2-receptor antagonists in the dog: their possible role in gastric motor activity. Gastrointest. Motil. 2: 273-280
16. Nagano, T., Ikawa, K., Takeyama, M. (1998) Enzyme immunoassay of calcitonin gene-related peptide-like immunoreactive substance in human plasma and saliva. Jpn. J. Hosp. Pharm. 24: 363-369
17. Otsuka, M., Konishi, S., Yanagasiwa, M., Tsunoo, A., Akagi, H. (1982) Role of substance P as a sensory transmitter in spinal cord and sympathetic ganglia. Ciba Found. Symp. 91: 13-34
18. Rydning, A., Lyng, O., Aase, S., Gronbech, J. E. (1999) Substance P may attenuate gastric hyperemia by a mast cell-dependent mechanism in the damaged gastric mucosa. Am. J. Physiol. 277: G1064-G1073
19. Tache, Y., Pappas, T., Lauffenburger, M., Goto, Y., Walsh, J. H., Debas, H. (1984) Calcitonin gene-related peptide: potent peripheral inhibitor of gastric acid secretion in rats and dogs. Gastroenterology 87: 344-349
20. Takeyama, M., Mori, K., Takayama, F., Kondo, K., Kitagawa, K., Fujii, N. (1990a) Enzyme immunoassay of substance P-like immunoreactive substance in human plasma and saliva. Chem. Pharm. Bull. 38: 3494-3496
21. Takeyama, M., Wakayama, K., Takayama, F., Kondo, K., Fujii, N., Yajima, H. (1990b) Micro-enzyme immunoassay of vasoactive intestinal polypeptide (VIP)-like immunoreactive substance in bovine milk. Chem. Pharm. Bull. 38: 960-962
22. Trasforini, G., Margutti, A., Vergnani, L., Ambrosio, M. R., Valentini, A., Rossi, R., Portaluppi, F., Uberti, E. C. D. (1994) Evidence that enhancement of cholinergic tone increase basal plasma levels of calcitonin gene-related peptide in normal man. J. Clin. Endocrinol. Metab. 78: 763-766
23. 2-receptor antagonist, and its possible mechanism of action in dogs and rats. J. Pharmacol. Exp. Ther. 264: 152-157
24. von Euler, U. S., Gaddum, J. H. (1931) An unidentified depressor substance in certain tissue extracts. J. Physiol. 72: 74-87