Substance P may attenuate gastric hyperemia by a mast cell-dependent mechanism in the damaged gastric mucosa

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 277, Issue 5 40-5, 1999, Pages

  Rydning, Astrid ^a,b   Lyng, Oddveig ^a   Aase, Steinar ^a   Grønbech, Jon Erik ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

Calcitonin gene related peptide; Gastric hyperemia; Proteases

Indexed keywords

APROTININ; CALCITONIN GENE RELATED PEPTIDE; CROMOGLYCATE DISODIUM; KETOTIFEN; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SODIUM CHLORIDE; SUBSTANCE P;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME RELEASE; HYPEREMIA; LASER DOPPLER FLOWMETRY; MALE; MAST CELL DEGRANULATION; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH BLOOD FLOW; STOMACH MUCOSA LESION;

EID: 0032739409     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1999.277.5.g1064     Document Type: Article

References (40)

1. Beck, P. L., G. P. Morris, and J. L. Wallace. Reduction of ethanol-induced gastric damage by sodium cromoglycate and FPL-52694. Role of leukotrienes, prostaglandines, and mast cells in the protective mechanism. Can. J. Physiol. Pharmacol. 67: 287-293, 1989.
2. Brain, S. D., and T. J. Williams. Substance P regulates the vasodilator activity of calcitonin gene-related peptide. Nature 335: 73-75, 1988.
3. Caughey, G. H., F. Leidig, N. F. Viro, and J. A. Nadel. Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase. J. Pharmacol. Exp. Ther. 244: 133-137, 1988.
4. Craps, L. P. Immunologic and therapeutic aspects of ketotifen. J. Allergy Clin. Immunol. 76: 389-393, 1985.
5. Dzienis, H., J. E. Grønbech, J. E. Varhaug, J. Lekven, and K. Svanes. Regional blood flow and acid secretion associated with damage and restitution at the gastric surface epithelium in cats. Eur. Surg. Res. 19: 98-112, 1987.
6. Foreman, J. C., C. C. Jordan, P. Oehme, and H. Renner. Structure-activity relationships for some substance-P related peptides that cause wheal and flare reactions in human skin. J. Physiol. (Lond.) 335: 449-465, 1983.
7. Gervasoni, J. E., D. H. Conrad, T. E. Hugli, L. B. Schwartz, and S. Ruddy. Degradation of human anaphylatoxin C3a by rat peritoneal mast cells: a role for the secretory granule enzyme chymase and heparin proteoglycan. J. Immunol. 136: 285-292, 1986.
8. Goetzl, E. J., T. Chernov, F. Renold, and D. G. Payan. Neuropeptide regulation of the expression of immediate hypersensitivity. J. Immunol. 135: 802S-805S, 1985.
9. Grant, S. M., K. L. Goa, A. Fitton, and E. M. Sorkin. Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders. Drugs 40: 412-448, 1990.
10. Green, T., and G. J. Dockray. Characterization of the peptidergic afferent innervation of the stomach in the rat, mouse and guinea-pig. Neuroscience 25: 181-193, 1988.
11. Grønbech, J. E., K. Grong, J. E. Varhaug, J. Lekven, and K. Svanes. Gastric epithelial restitution at low luminal pH during influence of pentagastrin or cimetidine in the cat. Gastroenterology 93: 753-764, 1987.
12. Grønbech, J. E., and E. R. Lacy. Substance P attenuates gastric mucosal hyperemia after stimulation of sensory neurons in the rat stomach. Gastroenterology 106: 440-449, 1994.
13. Grønbech, J. E., and E. R. Lacy. Role of gastric blood flow in impaired defense and repair of aged rat stomachs. Am. J. Physiol. 269 (Gastrointest. Liver Physiol. 32): G737-G744, 1995.
14. Grønbech, J. E., and E. R. Lacy. Role of sensory afferent neurons in hypertonic damage and restitution of the rat gastric mucosa. Gastroenterology 111: 1474-1483, 1996.
15. Grønbech, J. E., K. Matre, L. Stangeland, and J. E. Varhaug. Gastric mucosal repair in the cat: role of the hyperemic response to mucosal damage. Gastroenterology 95: 311-320, 1988.
16. Guth, P. H., and F. W. Leung. Physiology of the gastric circulation. In: Physiology of the Gastrointestinal Tract, edited by L. R. Johnson. New York: Raven, 1987, vol. 2, p. 1031-1053.
17. Guttu, K., H. Sørbye, H. Gislason, K. Svanes, and J. E. Grønbech. Role of bicarbonate in blood flow-mediated protection and repair of damaged gastric mucosa in the cat. Gastroenterology 107: 149-159, 1994.
18. Heinemann, A., M. Jocic, G. Herzeg, and P. Holzer. Tachykinin inhibition of acid-induced gastric hyperemia in the rat. Br. J. Pharmacol. 119: 1525-1532, 1996.
19. 2 receptor ligands. Neurosci. Lett. 237: 133-135, 1997.
20. Holzer, P., and P. H. Guth. Neuropeptide control of rat gastric mucosal blood flow. Increase by calcitonin gene-related peptide and vasoactive intestinal polypeptide, but not substance P and neurokinin A. Circ. Res. 68: 100-105, 1991.
21. Holzer, P., E. H. Livingston, and P. H. Guth. Sensory neurons signal for an increase in rat gastric mucosal blood flow in the face of pending acid injury. Gastroenterology 101: 416-423, 1991.
22. Holzer, P., E. H. Livingston, A. Saria, and P. H. Guth. Sensory neurons mediate protective vasodilation in rat gastric mucosa. Am. J. Physiol. 260 (Gastrointest. Liver Physiol. 23): G363-G370, 1991.
23. Karmeli, F., R. Eliakim, E. Okon, and D. Rachmilewitz. Gastric mucosal damage by ethanol is mediated by stubstance P and prevented by ketotifen, a mast cell stabilizer. Gastroenterology 100: 1206-1216, 1991.
24. Kwok, Y. N., and C. H. S. McIntosh. Release of substance P-like immunoreactivity from the vascularly perfused rat stomach. Eur. J. Pharmacol. 180: 201-207, 1990.
25. Lacy, E. R., and S. Ito. Rapid epithelial restitution of the rat gastric mucosa after ethanol injury. Lab. Invest. 51: 573-583, 1984.
26. Li, D. S., H. E. Raybould, E. Quintero, and P. E. Guth. Role of calcitonin gene-related peptide in gastric hyperemic response to intragastric capsaicin. Am. J. Physiol. 261 (Gastrointest. Liver Physiol. 24): G657-G661, 1991.
27. Li, D. S., H. E. Raybould, E. Quintero, and P. H. Guth. Calcitonin gene-related peptide mediates the gastric hyperemic response to acid back-diffusion. Gastroenterology 102: 1124-1128, 1992.
28. Main, I. H. M., and B. J. R. Whittle. A study of the vascular and acid-secretory responses of the rat gastric mucosa to histamine. J. Physiol. (Lond.) 257: 407-418, 1976.
29. Mersereau, W. A., and E. J. Hinchey. Effect of acidity on gastric ulceration induced by hemorrhage in the rat, utilizing a gastric chamber technique. Gastroenterology 64: 1130-1135, 1973.
30. Mio, M., K. Izushi, and K. Tasaka. Substance P-induced histamine release from rat peritoneal mast cells and its inhibition by antiallergic agents and calmodulin inhibitors. Immunopharmacology 22: 59-66, 1991.
31. Ritchie, W. P. Acute gastric mucosal damage induced by bile salts, acid and ischaemia. Gastroenterology 68: 699-707, 1975.
32. Shepherd, A. P., and J. W. Kiel. Gastrointestinal blood flow-measuring techniques. In: Handbook of Physiology. The Gastrointestinal System. Motility and Circulation. Bethesda: Am. Physiol. Soc., 1989, vol. 1, sect. 6, pt. 2, chapt. 37, p. 1335-1370.
33. Skolleborg, K. C., J. E. Grønbech, K. Grong, F. E. Åbyholm, and J. Lekven. Distribution of cardiac output during pentobarbital versus midazolam/fentanyl/fluanisone anesthesia in the rat. Lab. Anim. 24: 221-227, 1990.
34. Stead, R. H., M. F. Dixon, N. H. Bramwell, R. H. Riddell, and J. Bienenstock. Mast cells are closely apposed to nerves in the human gastrointestinal mucosa. Gastroenterology 97: 575-585, 1989.
35. Stead, R. H., M. Tomioka, G. Quinonez. G. T. Simon, S. Y. Felten, and J. Bienenstock. Intestinal mucosal mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves. Proc. Natl. Acad. Sci. USA 84: 2975-2979, 1987.
36. Stroff, T., S. Plate, J. S. Ebrahim, K. H. Erlich, M. Respondek, and B. M. Peskar. Tachykinin-induced increase in gastric mucosal resistance: role of primary afferent neurons, CGRP, and NO. Am. J. Physiol. 271 (Gastrointest. Liver Physiol. 34): G1017-G1027, 1996.
37. Svanes, K., S. Ito, K. Takeuchia, and W. Silen. Restitution of the surface epithelium of the in vitro frog gastric mucosa after damage with hyperosmolar sodium chloride. Gastroenterology 82: 1409-1426, 1982.
38. Walls, A. F., S. D. Brain, A. Desai, P. J. Jose, E. Hawkins, M. K. Church, and T. J. Williams. Human mast cell tryptase attenuates the vasodilatory activity of calcitonin gene related peptide. Biochem. Pharmacol. 43: 1243-1248, 1992.
39. 2α, and thromboxane mimetic U-46619 on rat submucosal microcirculation in vivo. Am. J. Physiol. 248 (Gastrointest. Liver Physiol. 11): G580-G586, 1985.
40. Winer, B. J. Statistical Principles in Experimental Design (2nd ed.). Tokyo, Japan: McGraw-Hill Kogakusha, 1971, p. 514-603.