Plasma amino acid concentrations in healthy and cognitively impaired oldest-old individuals: Associations with anthropometric parameters of body composition and functional disability

British Journal of Nutrition

Volumn 88, Issue 5, 2002, Pages 563-572

  Ravaglia, Giovanni ^a   Forti, Paola ^a   Maioli, Fabiola ^a   Bianchi, Giampaolo ^a   Sacchetti, Loredana ^a   Talerico, Teresa ^a   Nativio, Valeria ^a   Mariani, Erminia ^b   Macini, Pierluigi ^c  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^c Emilia Romagna Regional Health Care Department   (Italy)

Author keywords

Body composition; Cognitive function; Oldest old; Physical disability; Plasma amino acids

Indexed keywords

ALANINE; ALBUMIN; AMINO ACID; ARGININE; ASPARAGINE; BRANCHED CHAIN AMINO ACID; C REACTIVE PROTEIN; CHOLESTEROL; CITRULLINE; CREATININE; CYSTINE; ESSENTIAL AMINO ACID; GLYCINE; HISTIDINE; ISOLEUCINE; LEUCINE; LYSINE; METHIONINE; NEUROTRANSMITTER; ORNITHINE; PHENYLALANINE; PROLINE; SERINE; SOMATOMEDIN C; TAURINE; THREONINE; TRIACYLGLYCEROL; TYROSINE; UNINDEXED DRUG; VALINE;

AGE; AGED; AMINO ACID BLOOD LEVEL; AMINO ACID TRANSPORT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BIOCHEMISTRY; BLOOD SAMPLING; BODY COMPOSITION; BRAIN; COGNITION; COGNITIVE DEFECT; COMMUNITY; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DAILY LIFE ACTIVITY; DEMENTIA; DIET RESTRICTION; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; FEMALE; GERIATRIC DISORDER; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; MINI MENTAL STATE EXAMINATION; MUSCLE MASS; NEUROTRANSMITTER RELEASE; PATHOGENESIS; PHYSICAL DISABILITY; PRECURSOR; PROTEIN CALORIE MALNUTRITION; VENOUS BLOOD;

EID: 0036848627     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN2002700     Document Type: Article

References (47)

1. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, 4th ed: DSM-IV. Washington, DC: American Psychiatric Association.
2. Antener I, Tonney G, Verwilghen AM & Mauron J (1981) Biochemical study of malnutrition. Part IV. Determination of amino acids in the serum, erythrocytes, urine and stool ultrafiltrates. International Journal for Vitamin and Nutrition Research 51, 64-78.
3. Bancel E, Strubel D, Bellet H, Polge A, Peray P & Magnan de Bornier B (1994) Effet de l'age et du sexe sur les concentrations des acides amines plasmatiques (Effect of the age and the sex on plasma concentration of amino acids). Annales de Biologie Clinique 52, 667-670.
4. Benabe JE & Martinez-Maldonado M (1998) The impact of malnutrition on kidney function. Mineral and Electrolyte Metabolism 24, 20-26.
5. Bonaccorso S, Lin A, Song C, Verkerk R, Kenis G, Bosmans E, Scharpe S, Vandewoude M, Dossche A & Maes M (1998) Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer's disease (DAT): lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT. Aging Clinical and Experimental Research 10, 316-323.
6. Caballero B, Gleason RE & Wurtman RJ (1991) Plasma amino acid concentrations in healthy elderly men and women. American Journal of Clinical Nutrition 53, 1249-1252.
7. Chumlea WC, Roche AF & Steinbaugh ML (1985) Estimating stature from knee height for persons 60 to 90 years of age. Journal of the American Geriatric Society 33, 116-121.
8. Constans T, Alix E & Dardaine V (2000) Malnutrition protéinoénergetique: Méthodes diagnostiques et épidémiologie (Protein-energy malnutrition. Diagnostic methods and epidemiology). Presse Medicale 29, 2171-2176.
9. Cummings JL (1993) Mini-Mental State Examination: norms, normals and numbers. JAMA 269, 2420-2421.
10. Fastbom J, Wills P, Cornelius C, Viitanen M & Winblad B (1996) Levels of serum creatinine and estimated creatinine clearance over the age of 75: a study of an elderly Swedish population. Archives of Gerontology and Geriatrics 23, 179-188.
11. Fekkes D, van der Cammen TJ, van Loon CP, Verschoor C, van Harskamp F, de Konig I, Schudel WJ & Pepplinkhuinzen L (1998) Abnormal amino acid metabolism in patients with early stage Alzheimer dementia. Journal of Neural Transmission 105, 287-294.
12. Felig P & Bergman M (1995) The endocrine pancreas: diabetes mellitus. In Endocrinology and Metabolism, 3rd ed., pp. 1107-1250 [P Felig, J Baxter and LA Frohman, editors]. New York: McGraw Hill.
13. Fiorini F & Cavatorta F (1997) Protein and amino acid metabolism in chronic renal failure. Minerva Urologica e Nefrologica 49, 189-197.
14. Flacker JM & Lipsitz LA (2000) Large neutral amino acid changes and delirium in febrile elderly medical patients. Journal of Gerontology Biological Sciences 55A, B249-B252.
15. Flier JS & Underhill LH (1997) Insulin-like growth factors. New England Journal of Medicine 336, 633-640.
16. Frisancho AR (1981) New norms of upper limb fat and muscle area for assessment of nutritional status. American Journal of Clinical Nutrition 34, 2540-2545.
17. Hargreaves KM & Pardridge WM (1988) Neutral amino acid transport at the human blood brain barriers. Journal of Biological Chemistry 263, 19392-19397.
18. Hubbard RW & Mejia A (1995) Human plasma preservation for amino acid analysis by immediate low temperature freezing. Clinical Biochemistry 28, 318-320.
19. Huttenlocher PR (2000) The neuropathology of phenylketonuria: human and animal studies. European Journal of Pediatrics 159, S102-S106.
20. Jeevanandam M, Young DH, Ramias L & Schiller WR (1990) Effect of major trauma on plasma free amino acid concentrations in geriatric patients. American Journal of Clinical Nutrition 51, 1040-1045.
21. Katz S, Downs TD, Cash HR & Grotsz RC (1970) Progress in development of the index of ADL. Gerontologist 10, 20-30.
22. Laidlaw SA, Berg RL, Kopple JD, Naito H, Walker WG & Walser M (1994) Patterns of fasting plasma amino acid levels in chronic renal insufficiency: results from the feasibility phase of the modification of diet in Renal Disease Study. American Journal of Kidney Diseases 23, 504-513.
23. Lieberman HR (1999) Amino acid and protein requirements: cognitive performance, stress, and brain function. In The Role of Protein and Amino Acids in Sustaining and Enhancing Performance, pp. 289-307 (Committee on Military Nutrition Research - Committee on Body Composition, Nutrition and Health). Washington, DC: National Academy Press.
24. Ligthart GJ, Corberand JX, Fournier C, Galanaud P, Hijmans W, Kennes B, Muller-Hermelink HK & Steinmann GG (1984) Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mechanisms of Ageing and Development 28, 47-55.
25. McKhann G, Drachman D, Folstein M, Katzman R, Price D & Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of NINCDS-ADRDA Work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34, 939-944.
26. Marchesini G, Bianchi GP, Vilstrup H, Checchia GA, Patrono D & Zoli M (1987) Plasma clearances of branched-chain amino acids in control subjects and in patients with cirrhosis. Journal of Hepatology 4, 108-117.
27. Melton LJ III, Khosla S & Riggs BL (2000) Epidemiology of Sarcopenia. Mayo Clinic Proceedings 75, Suppl., S10-S13.
28. Niederstadt C & Steinhoff J (1997) Die Nieren im Alter (The kidneys in ageing). Zeitschrift für Gerontologie und Geriatrie 30, 200-207.
29. Pardridge WM & Fierer G (1990) Transport of tryptophan into brain from circulating, albumin-bound pools in rats and rabbits. Journal of Neurochemistry 54, 971-976.
30. Polge A, Bancel E, Bellet H, Strubel D, Poirey S, Peray P, Carlet C & Magnan de Bornier B (1997) Plasma amino acid concentrations in elderly patients with protein energy malnutrition. Age and Ageing 26, 457-462.
31. Ravaglia G, Forti P, De Ronchi D, Maioli F, Nesi B, Cucinotta D, Bernardi M & Cavalli G (1999) Prevalence and severity of dementia among northern Italian centenarians. Neurology 53, 416-418.
32. Ravaglia G, Forti P, Maioli F, Boschi F, Bernardi M, Pratelli L, Pizzoferrato A & Gasbarrini G (1996) The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds. Journal of Clinical Endocrinology and Metabolism 81, 1173-1178.
33. Ravaglia G, Forti P, Maioli F, Boschi F, Cicognani A, Beranrdi M, Pratelli L, Pizzoferrato A, Porcu S & Gasbarrini G (1997a) Determinants of functional status in healthy Italian nonagenarians: a comprehensive functional assessment by the instruments of geriatric practice. Journal of the American Geriatric Society 45, 1196-1202.
34. Ravaglia G, Forti P, Maioli F, Nesi B, Pratelli L, Savarino L, Cucinotta D & Cavalli G (2000) Blood micronutrient and thyroid hormone concentrations in the oldest-old. Journal of Clinical and Endocrinology Metabolism 85, 2260-2265.
35. Ravaglia G, Morini P, Forti P, Maioli F, Bernardi M & Gasbarrini G (1997b) Anthropometric characteristics of healthy Italian nonagenarians and centenarians. British Journal of Nutrition 77, 9-17.
36. Raynaud-Simon A & Lesourd B (2000) Dénutrition du sujet agé: Conséquences cliniques (Malnutrition in the elderly. Clinical consequences). Presse Medicale 29, 2183-2190.
37. Ritchie K & Kildea D (1995) Is senile dementia "age-related" or "ageing-related"? Evidence from meta-analysis of dementia prevalence in the oldest-old. Lancet 346, 931-934.
38. Rudman D, Abbasi AA, Chaudry F & Mattson DE (1991) Delayed plasma clearance of phenylalanine and tyrosine in elderly men. Journal of the American Geriatric Society 39, 33-38.
39. Rudman D, Mattson D, Feller AG, Cotter R & Johnson RC (1989) Fasting plasma amino acids in elderly men. American Journal of Clinical Nutrition 49, 559-566.
40. Schlienger JL, Pradignac A & Grunenberger F (1995) Nutrition of the elderly: a challenge between facts and needs. Hormone Research 43, 46-51.
41. Shenkin A, Cederblad G, Elia M & Isaksson B (1996) Laboratory assessment of protein-energy status. Clinica Chimica Acta 253, S5-S59.
42. Thomas AJ (1998) Nutrition. In Brocklehurst's Textbook of Geriatric Medicine and Gerontology, 5th ed., 899-912 [R Tallis, H Fillit and JC Brocklehurst, editors]. Edinburgh: Churchill Livingstone.
43. Valente C, Maione P, Lippi A, Taiti P, Cavarzeran F, Rocca WA, Amaducci L & Bavazzano A (1992) Validazione del Mini Mental State Examination (MMSE) come strumento di screening per demenza in una popolazione Italiana (Validation of the Mini Mental State Examination (MMSE) as a screening instrument for dementia in an Italian Population). Giornale di Gerontologia 40, 161-165.
44. World Health Organization (1992) The International Classification of Diseases, 10th revision: ICD-10: Geneva: WHO.
45. World Health Organization (1998) Expert Subcommittee on the Use and Interpretation of Anthropometry in the Elderly: Uses and interpretation of anthropometry in the elderly for the assessment of physical status Report to the Nutrition Unit of the World Health Organization. Journal of Nutrition, Health and Aging 2, 5-17.
46. Young V (1990) Amino acids and proteins in relation to the nutrition of elderly people. Age and Ageing 19, S10-S24.
47. Zoli M, Marchesini G, Angiolini A, Dondi C, Bianchi FB & Pisi E (1981) Plasma amino acids as markers of liver dysfunction in cirrhotics. Scandinavian Journal of Gastroenterology 16, 689-692.