Peptidyl dipeptidases (Ance and Acer) of Drosophila melanogaster: Major differences in the substrate specificity of two homologs of human angiotensin I-converting enzyme

Peptides

Volumn 23, Issue 11, 2002, Pages 2025-2034

  Siviter, Richard J ^a   Nachman, Ronald J ^b   Dani, M Paulina ^a   Keen, Jeffrey N ^a   Shirras, Alan D ^c   Isaac, R Elwyn ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b U S DEPARTMENT OF AGRICULTURE   (United States)

^c LANCASTER UNIVERSITY   (United Kingdom)

Author keywords

Insect peptides; Insect tachykinin; Peptidases; Peptide metabolism; Tachykinin related peptides

Indexed keywords

AMINO ACID; DIPEPTIDYL CARBOXYPEPTIDASE; INSECT PROTEIN; ISOENZYME; LEUCINE ENKEPHALINAMIDE; LEUCOKININ I; PEPTIDE; SODIUM CHLORIDE; TACHYKININ 1; TACHYKININ 2; TACHYKININ 3; TACHYKININ 4; TACHYKININ 5; UNCLASSIFIED DRUG; ACER PROTEIN, DROSOPHILA; ANCE PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; METALLOPROTEINASE;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HEMOLYMPH; IN VITRO STUDY; MAMMAL; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN HYDROLYSIS; SEQUENCE HOMOLOGY; ANIMAL; HYDROLYSIS; KINETICS; MASS SPECTROMETRY; METABOLISM; POLYACRYLAMIDE GEL ELECTROPHORESIS;

ACER; DROSOPHILA MELANOGASTER; INSECTA; MAMMALIA; MELANOGASTER;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HYDROLYSIS; KINETICS; METALLOENDOPEPTIDASES; PEPTIDYL-DIPEPTIDASE A; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

EID: 0036848439     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(02)00190-0     Document Type: Article

References (31)

1. Bidlingmeyer B.A., Cohen S.A., Tarvin T.L. Rapid analysis of amino acids using pre-column derivatization. J. Chromatogr. 336:1984;93-104.
2. Coates D., Isaac R.E., Cotton J., Siviter R., Williams T.A., Shirras A.et al. Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme. Biochemistry. 39:2000;8963-8969.
3. Cornell M.J., Williams T.A., Lamango N.S., Coates D., Corvol P., Soubrier F.et al. Cloning and expression of an evolutionary conserved single-domain angiotensin-converting enzyme from Drosophila melanogaster. J. Biol. Chem. 270:1995;13613-13619.
4. Corvol P., Williams T.A., Soubrier F. Peptidyl dipeptidase a: angiotensin I-converting enzyme. Methods Enzymol. 248:1995;283-305.
5. Dani MP. Localization of Angiotensin I-Converting Enzyme in the Diptera Drosophila melanogatser and Lucilia sericata. Ph.D. Thesis, University of Leeds, 2000.
6. Dive V., Cotton J., Yiotakis A., Michaud A., Vassiliou S., Jiracek J.et al. Rxp 407, a phosphinic peptide, is a potent inhibitor of angiotensin I-converting enzyme able to differentiate between its two active sites. Proc. Natl. Acad. Sci. U.S.A. 96:1999;4330-4335.
7. Erdos E.G. Angiotensin I-converting enzyme and the changes in our concepts through the years - Dahl Lewis, K. Memorial lecture. Hypertension. 16:1990;363-370.
8. Erdos E.G., Skidgel R.A. Structure and functions of human angiotensin I-converting enzyme (kininase II). Biochem. Soc. Trans. 13:1985;42-44.
9. Houard X., Williams T.A., Michaud A., Dani P., Isaac R.E., Shirras A.D.et al. The Drosophila melanogaster-related angiotensin I-converting enzymes Acer and Ance: distinct enzymic characteristics and alternative expression during pupal development. Eur. J. Biochem. 257:1998;599-606.
10. Isaac R., Schoofs L., Williams T.A., Veelaert D., Sajid M., Corvol P.et al. A novel peptide-processing activity of insect peptidyl-dipeptidase a (angiotensin I-converting enzyme): the hydrolysis of lysyl-arginine and arginyl-arginine from the C-terminus of an insect prohormone peptide. Biochem. J. 330:1998;61-65.
11. Isaac R.E., Michaud A., Keen J.N., Williams T.A., Coates D., Wetsel W.C.et al. Hydrolysis by somatic angiotensin I-converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with Gly-Arg/Lys-Arg, but not from diarginyl insulin. Eur. J. Biochem. 262:1999;569-574.
12. Isaac R.E., Parkin E.T., Keen J.N., Nassel D.R., Siviter R.J., Shirras A.D. Inactivation of a tachykinin-related peptide: identification of four neuropeptide-degrading enzymes in neuronal membranes of insects from four different orders. Peptides. 23:2002;725-733.
13. Isaac R.E., Williams T.A., Sajid M., Corvol P., Coates D. Cleavage of arginyl-arginine and lysyl-arginine from the C-terminus of pro-hormone peptides by human germinal angiotensin I-converting enzyme (ACE) and the C-domain of human somatic ACE. Biochem. J. 328:1997;587-591.
14. Jaspard E., Wei L., Alhenc-Gelas F. Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kinase II). Studies with bradykinin and other natural peptides. J. Biol. Chem. 268:1993;9496-9503.
15. Lamango N.S., Nachman R.J., Hayes T.K., Strey A., Isaac R.E. Hydrolysis of insect neuropeptides by an angiotensin-converting enzyme from the housefly, Musca domestica. Peptides. 18:1997;47-52.
16. Lamango N.S., Sajid M., Isaac R.E. Purification and properties of an angiotensin-converting enzyme from the housefly, Musca domestica. Biochem. J. 314:1996;639-646.
17. Nachman R.J., Moyna G., Williams H.J., Zabrocki J., Zadina J.E., Coast G.M.et al. Comparison of active conformations of the insectatachykinin/tachykinin and insect kinin/tyr-w-mif-1 neuropeptide family pairs. Ann N. Y. Acad. Sci. 897:1999;388-400.
18. Nassel D.R. Tachykinin-related peptides in invertebrates: a review. Peptides. 20:1999;141-158.
19. Shore S.A., Martins M.A., Drazen J.M. Pulmonary mechanical responses to intravenously administered capsaicin in guinea-pigs: effect of peptidase inhibitors. Pulm. Pharmacol. 6:1993;193-199.
20. Siviter R.J., Coast G.M., Winther A.M., Nachman R.J., Taylor C.A., Shirras A.D.et al. Expression and functional characterization of a Drosophila neuropeptide precursor with homology to mammalian preprotachykinin a. J. Biol. Chem. 275:2000;23273-23280.
21. Skidgel R.A. Characterization of the metabolism of substance P and neurotensin by human angiotensin I-converting enzyme and "enkephalinase" Prog. Clin. Biol. Res. 192:1985;371-378.
22. Stephenson S.L., Kenny A.J. Metabolism of neuropeptides. Hydrolysis of the angiotensins, bradykinin, substance P and oxytocin by pig kidney microvillar membranes. Biochem. J. 241:1987;237-247.
23. Strittmatter S.M., Thiele E.A., Kapiloff M.S., Snyder S.H. A rat-brain isozyme of angiotensin-converting enzyme: unique specificity for amidated peptide-substrates. J. Biol. Chem. 260:1985;9825-9832.
24. Subissi A., Guelfi M., Criscuoli M. Angiotensin converting enzyme inhibitors potentiate the bronchoconstriction induced by substance P in the guinea-pig. Br. J. Pharmacol. 100:1990;502-506.
25. Tatei K., Cai H., Ip Y.T., Levine M. Race - a Drosophila homolog of the angiotensin-converting enzyme. Mech. Dev. 51:1995;157-168.
26. Taylor C.A.M., Coates D., Shirras A.D. The Acer gene of Drosophila codes for an angiotensin-converting enzyme homolog. Gene. 181:1996;191-197.
27. Thiele E.A., Strittmatter S.M., Snyder S.H. Substance-K and substance-P as possible endogenous substrates of angiotensin converting enzyme in the brain. Biochem. Biophys. Res. Commun. 128:1985;317-324.
28. Wei L., Alhencgelas F., Corvol P., Clauser E. The two homologous domains of human angiotensin I-converting enzyme are both catalytically active. J. Biol. Chem. 266:1991;9002-9008.
29. Wei L., Clauser E., Alhencgelas F., Corvol P. The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors. J. Biol. Chem. 267:1992;13398-13405.
30. Winther A.M., Nassel D.R. Intestinal peptides as circulating hormones: release of tachykinin-related peptide from the locust and cockroach midgut. J. Exp. Biol. 204:2001;1269-1280.
31. Yokosawa H., Endo S., Ogura Y., Ishii S. A new feature of angiotensin-converting enzyme in the brain: hydrolysis of substance P. Biochem. Biophys. Res. Commun. 116:1983;735-742.