Reduced corticomotoneuronal excitatory postsynaptic potentials (EPSPs) with normal ia afferent EPSPs in amyotrophic lateral sclerosis

Neurology

Volumn 47, Issue 6, 1996, Pages 1555-1561

  Nakajima, M ^a   Eisen, A ^a,c   McCarthy, R ^b   Olney, R K ^b   Aminoff, M J ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; HAND MUSCLE; HUMAN; MALE; MOTOR NEURON DISEASE; PRIORITY JOURNAL; SENSORY NERVE; SPINAL CORD MOTONEURON; SYNAPTIC TRANSMISSION; VOLUNTARY MOVEMENT;

EID: 0029770075     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.47.6.1555     Document Type: Article

References (43)

1. Hughes JT. Pathology of amyotrophic lateral sclerosis. In: Rowland LP, ed. Human motor neuron disease. New York: Raven Press, 1982:61-74.
2. Porter R, Lemon R. Corticospinal function and voluntary movement. Monographs of the Physiological Society No. 45. Oxford: Clarendon Press, 1993:1-421.
3. Iwatsubo T, Kuzuhara S, Kanemitsu B, et al. Corticofugal projections to the motor nuclei of the brainstem and spinal cord in humans. Neurology 1990;40:309-312.
4. Eisen A, Kim S, Pant B. Amyotrophic lateral sclerosis (ALS): a phylogenetic disease of the corticomotoneuron? Muscle Nerve 1992;15:219-228.
5. Eisen A. Amyotrophic lateral sclerosis is a multifactorial disease. Muscle Nerve 1995;18:741-752.
6. Chou SM, Norris FH. Amyotrophic lateral sclerosis: lower motor neuron disease spreading to upper motor neurons. Muscle Nerve 1993;16:864-869.
7. Charcot JM. Sclérose des cordons latéraux de la moelle épinière chez femme hystérique atteinte de contracture permanente des quatre membres. Bull Soc Med Hop Paris. 1865; 2(suppl 2):2442.
8. Charcot JM, Joffroy A. Deux cas d'atrophie musculaire progressive avec lésions de la substance grise et des faisceaux anterolatéraux de la moelle épinière. Arch Physiol Norm Pathol 1869;2:354-367, 629-649, 744-760.
9. Hudson AJ, Kiernan JN. Preservation of certain voluntary muscles in motoneurone disease. [letter]. Lancet 1988;1:652-653.
10. Kiernan JA, Hudson AJ. Changes in sizes of cortical and lower motor neurons in amyotrophic lateral sclerosis. Brain 1991;114:843-853.
11. Pamphlett R, Kril J, Hng TM. Motor neuron disease: a primary disorder of corticomotoneuron? Muscle Nerve 1995;18: 314-318.
12. Mills KR. Motor neuron disease: studies of the corticospinal excitation of single motor neurons by magnetic brain stimulation. Brain 1995;118:971-982.
13. Cheung G, Gawal MJ, Cooper PW, Farb RI, Ang LC. Amyotrophic lateral sclerosis: correlation of clinical and MRI imaging findings. Radiology 1995;194:263-270.
14. Pioro EP, Antel JP, Cashman NR, Arnold DL. Detection of cortical neuron loss in motor neuron disease by proton magnetic resonance spectroscopic imaging in vivo. Neurology 1994;44:1933-1938.
15. Kew JJ, Brooks DJ, Rassingham RE, Rothwell JC, Frackowiak RS, Leigh PN. Cortical function in progressive muscular atrophy and amyotrophic lateral sclerosis. J Neurol Sci 1994; 124(suppl):72.
16. Awiszus F, Feistner H. Abnormal EPSPs evoked by magnetic brain stimulation in hand muscle motoneurons of patients with amyotrophic lateral sclerosis. Electroencephalogr Clin Neurophysiol 1993;89:408-414.
17. Awiszus F, Feistner H. Comparison of single motor unit responses to transcranial magnetic and peroneal nerve stimulation in the tibialis anterior muscle of patients with amyotrophic lateral sclerosis. Electroenceph Clin Neurophysiol 1995; 97:90-95.
18. Eisen A, Entezari-Taher M, Stewart H. Cortical projections to spinal motoneurons: changes with aging and amyotrophic lateral sclerosis. Neurology 1996;46:1396-1404.
19. Murray NMF. Motor evoked potentials. In: Aminoff MJ, ed. Electrodiagnosis in clinical neurology. New York: Churchill Livingstone, 1992:605-626.
20. Eisen A. Cortical and peripheral nerve magnetic stimulation. Methods Clin Neurophysiol 1992;3:65-84.
21. Day BI, Dressler D, Maertens de Noordhout A, et al. Electrical and magnetic stimulation of the human motor cortex: surface EMG and single motor unit responses. J Physiol 1989; 412:449-473.
22. Mills KR, Boniface SJ, Schubert M. The firing probability of single motor units following transcranial magnetic stimulation in healthy subjects and patients with neurological disease. In: Levy WJ, Cracco RQ, Barker AT, Rothwell J, eds. Magnetic motor stimulation: Basic principles and clinical experience (EEG Suppl 43). New York: Elsevier, 1991:100-110.
23. Boniface SJ, Mills KR, Schubert M. Responses of single motoneurons to magnetic brain stimulation in healthy subjects and patients with multiple sclerosis. Brain 1991;114:643-662.
24. Palmer E, Ashby P. Corticospinal projections to upper limb motoneurons in humans. J Physiol 1992;448:397-411.
25. Palmer E, Ashby P. The transcortical nature of the late reflex responses in human small hand muscle to digital nerve stimulation. Exp Brain Res 1992;91:320-326.
26. Mills KR, Boniface SJ, Schubert M. Origin of the secondary increase in firing probability of human motoneurons following transcranial magnetic stimulation: studies in healthy subjects, type I hereditary motor and sensory neuropathy and multiple sclerosis. Brain 1991;114:2451-2463.
27. Bawa P, Lemon RN. Recruitment of motor units in response to transcranial magnetic stimulation in man. J Physiol 1993; 471:445-464.
28. Boniface SJ, Schubert M, Mills KR. Suppression and long latency excitation of single spinal motoneurons by transcranial magnetic stimulation in health, multiple sclerosis and stroke. Muscle Nerve 1994;17:642-646.
29. Brouwer B, Ashby P. Corticospinal projections to upper and lower limb spinal motoneurons in man. Electroencephalogr Clin Neurophysiol 1990;76:509-519.
30. Ashby P, Zilm D. Relationship between EPSP shape and cross-correlation profile explored by computer simulation for studies on human motoneurons. Exp Brain Res 1982;47:33-40.
31. Ashby P, Zilm D. Characteristics of postsynaptic potentials produced in single human motoneurons by homonymous group I volleys. Exp Brain Res 1982;47:41-48.
32. Fetz EE, Cheney PD. Post-spike facilitation of forelimb muscle activity by primate corticomotoneuronal cells. J Neurophysiol 1980;44:751-772.
33. Lemon RN, Mantel GWH, Muir RB. Corticospinal facilitation of hand muscles during voluntary movement in the conscious monkey. J Physiol 1986;381:497-527.
34. Nakajima M, Eisen A, Stewart H, et al. Spinal motoneurons in ALS are differentially excitable to peripheral and cortical stimuli. Neurology 1996;46(suppl):A472.
35. Rowland LP. Natural history and clinical features of amyotrophic lateral sclerosis and related motor neuron diseases. In: Calne DB, ed. Neurodegenerative diseases. Philadelphia: WB Saunders, 1994:507-521.
36. Ellaway PH. Cumulative sum technique and its application to the analysis of peri-stimulus time histograms. Electroencephalogr Clin Neurophysiol. 1978;45:302-304.
37. Buller NP, Garnett R, Stephens JA. The reflex response of single motor units in human hand muscles following muscle afferent stimulation. J Physiol 1980;303:337-349.
38. Mao CC, Ashby P, Wang M, McCrea D. Synaptic connections from large muscle afferents to the motoneurons of various leg muscles in man. Exp Brain Res 1984;56:341-350.
39. Awiszus F, Feistner H, Schafer SS. On a method to detect long-latency excitations and inhibitions of single hand muscle motoneurons in man. Exp Brain Res 1991;86:440-446.
40. Ashby P, Stålberg E, Winkler T, Hunter JP. Further observations on the depression of group Ia facilitation of motoneurons by vibration in man. Exp Brain Res 1987;69:1-6.
41. Mailis A, Ashby P. Alterations in group Ia projetons to motoneurons following spinal lesions in humans. J Neurophysiol 1990;64:637-647.
42. Hunter JP, Ashby P, Lange AE. Afferents contributing to the exaggerated long latency reflex response to electrical stimulation in Parkinson's disease. J Neurol Neurosurg Psychiatry 1988;51:1405-1410.
43. Miles TS, Turker KS, Le TH. Ia reflexes and EPSPs in human soleus motor neurons. Exp Brain Res 1989;77:628-636.