Altered Na+/H+ exchanger isoform I activity in immortalized lymphoblasts from women with pre-eclampsia: Evidence for an intermediate phenotype

Clinical Science

Volumn 103, Issue 5, 2002, Pages 503-509

  Lee, V M ^a   Quinn, P A ^a   Jennings, S C ^a   Halligan, A W F ^a   Ng, L L ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Intermediate phenotype; NHE 1 activity; Pre eclampsia

Indexed keywords

BIS(CARBOXYETHYL)CARBOXYFLUORESCEIN ACETOXYMETHYL ESTER; DYE; ISOPROTEIN; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL MEMBRANE TRANSPORT; CELL PH; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FLUOROMETRY; HOMEOSTASIS; HUMAN; HUMAN CELL; HYPERTENSION; LEUKOCYTE; LYMPHOBLAST; PH; PH MEASUREMENT; PHENOTYPE; PREECLAMPSIA; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; WESTERN BLOTTING;

EID: 0036845873     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs1030503     Document Type: Article

References (28)

1. Forrester, T. E., Grell, G. A., Bennett, F., Bernard, W. and Gordon, B. (1990) Persistence of high leucocyte sodium and blood pressure after pre-eclampsia. J. Hum. Hypertens. 4, 25-30
2. Heilmann, L., von Tempelhoff, G. F. and Ulrich, S. (1993) The Na +/K + co-transport system in erythrocytes from pregnant patients. Arch. Gynecol. Obstet. 253, 67-74
3. Graves, S. W., Lincoln, K., Cook, S. L. and Seety, E. W. (1993) Digitalis-like factor and digoxin-like immunoreactive factor in diabetic women with preeclampsia, transient hypertension of pregnancy, and normotensive pregnancy. Am. J. Hypertens. 8, 5-11
4. Delva, P., Capra, C., Degan, M. et al. (1989) High plasma levels of a ouabain-like factor in normal pregnancy and in pre-eclampsia. Eur. J. Clin. Invest. 19, 95-100
5. Gregoire, I., Roth, D., Siegenthaler, G. et al. (1988) Ouabain-displacing factor in normal pregnancy, pregnancy-induced hypertension and pre-eclampsia. Clin. Sci. 74, 307-310
6. Lopatin, D. A., Ailamazian, E. K., Dmitrieva, R. I. et al. (1999) Circulating bufodienolide and cardenolide sodium pump inhibitors in preeclampsia. J. Hypertens. 17, 1179-1187
7. Seon, R. and Forrester, T. (1989) Relationship between leucocyte sodium content and high blood pressure during development and resolution of pre-eclampsia. Clin. Sci. 76, 199-203
8. Siczkowski, M., Davies, J. E. and Ng, L. L. (1994) Activity and density of the Na +/H + antiporter in normal and transformed human lymphocytes and fibroblasts. Am. J. Physiol. 267, C745-C752
9. Sweeney, F. P., Siczkowski, M., Davies, J. E. et al. (1995) Phosphorylation and activity of Na +/H + exchanger isoform 1 of immortalized lymphoblasts in diabetic nephropathy. Diabetes 44, 1180-1185
10. + antiporter phenotype, abundance and phosphorylation of immortalized lymphoblasts from humans with hypertension. Hypertension 25, 971-977
11. La Pointe, M. S., Ye, M., Bacallao, R. and Batlle, D. (1997) NHE-1 protein in vascular smooth muscle and lymphocytes from the spontaneously hypertensive rat. Hypertension 30, 880-885
12. + exchanger activity and phosphorylation in temperature sensitive immortalized proximal tubule cell lines derived from the spontaneously hypertensive rat. Clin. Sci. 98, 409-418
13. Lee, V. M., Halligan, A. W. F. and Ng, L. L. (2001) Leucocyte intracellular pH and Na +/H + exchanger isoform-1 activity in postpartum women with pre-eclampsia. Br. J. Obstet. Gynaecol. 108, 615-622
14. Davey, D. A. and MacGillivray, I. (1988) The classification and definition of the hypertensive disorders of pregnancy. Am. J. Obstet. Gynecol. 158, 892-898
15. Bird, A. G., McLachlan, S. M. and Britton, S. (1981) Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein-Barr virus induced B-cell lines. Nature (London) 289, 300-301
16. + antiport characteristics. Clin. Sci. 77, 417-423
17. + antiport activity in human hypertension. J. Hypertens. 7, 471-475
18. Reuss, F. and Finn, A. L. (1975) Electrical properties of the cellular transepithelial pathway in Necturus gall bladder. I. Circuit analysis and steady state effects of mucosal solution ionic substitutions. J. Membr. Biol. 25, 115-139
19. Deutscher, M. P. (1990) Maintaining protein stability. Methods Enzymol. 182, 83-89
20. + antiporter phenotype and turnover of immortalized lymphoblasts from type I diabetic patients with nephropathy. J. Clin. Invest. 93, 2750-2757
21. + antiporter, a glycoprotein of 110 kD. Science 247, 723-726
22. Sweeney, F. P., Quinn, P. A. and Ng, L. L. (1997) Enhanced mitogen-activated protein kinase activity and phosphorylation of the Na +/H + exchanger isoform-1 of human lymphoblasts in hypertension. Metab. Clin. Exp. 46, 297-302
23. Mahnensmith, R. L. and Aronson, P. S. (1985) The plasma membrane sodium-hydrogen exchanger and its role in physiological and pathophysiological processes. Circ. Res. 56, 773-788
24. Wray, S. (1988) Smooth muscle intracellular pH: Measurement, regulation and function. Am. J. Physiol. 254, C213-C225
25. Blaustein, M. P. (1984) Sodium transport and hypertension. Where are we going? Hypertension 6, 445-453
26. Schorr, U., Blaschke, K., Beige, J., Distler, A. and Sharma A. M. (2000) G-protein beta3 subunit 825T allele and response to dietary salt in normotensive men. J. Hypertens. 18, 855-859
27. Bonanno, J. A. (1994) Bicarbonate transport under nominally bicarbonate-free conditions in bovine corneal endothelium. Exp. Eye Res. 58, 415-421
28. Aronson, P. S., Nee, J. and Suhm, M. A. (1982) Modifier role of internal H+ in activating the Na+-H+ exchanger in renal microvillus membrane vesicles. Nature (London) 299, 161-163