Enhanced mitogen-activated protein kinase activity and phosphorylation of the Na+/H+ exchanger isoform-1 of human lymphoblasts in hypertension

Metabolism: Clinical and Experimental

Volumn 46, Issue 3, 1997, Pages 297-302

  Sweeney, Frank P ^a   Quinn, Paulene A ^a   Ng, Leong L ^a  

^a LEICESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPORTER; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HYPERTENSION; LYMPHOBLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTON SODIUM EXCHANGE; SIGNAL TRANSDUCTION;

EID: 0031029195     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(97)90257-2     Document Type: Article

References (24)

1. + exchange and growth factor-induced cytosolic pH changes. Biochim Biophys Acta 988:73-97, 1989
2. Mahnensmith RL, Aronson PS: The plasma membrane sodiumhydrogen exchanger and its role in physiological and pathophysiological processes. Circ Res 56:773-788, 1985
3. Rosskopf D, Fromter E, Siffert W: Hypertensive sodium-proton exchanger phenotype persists in immortalized lymphoblasts from essential hypertensive patients. A cell culture model for human hypertension. J Clin Invest 92:2553-2559, 1993
4. + antiporter phenotype, abundance and phosphorylation of immortalized lymphoblasts from humans with hypertension. Hypertension 25:971-977, 1995
5. Boulton TG, Yancopoulos GD, Gregory JS, et al: An insulinstimulated protein kinase similar to yeast kinases involved in cell cycle control. Science 249:64-67, 1990
6. Boulton TG, Nye SH, Robbins DJ, et al: ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65:663-675, 1991
7. Davis RJ: The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268:14553-14556, 1993
8. Cano E, Mahadevan LC: Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 20:117-122, 1995
9. - tion. Proc Natl Acad Sci USA 90:8319-8323, 1993
10. mpk, the meiosisactivated myelin basic protein kinase. J Biol Chem 266:15180-15184, 1991
11. + exchange inhibitor, and its direct effect in cardiac ischaemia. Br J Pharmacol 109:562-568, 1993
12. + antiporter phenotype and turnover of immortalized lymphoblasts from type 1 diabetic patients with nephropathy. J Clin Invest 93:2750-2757, 1994
13. Wilkie N, Ng LL, Boarder MR: Angiotensin II stimulation of MAP kinases in cultured vascular smooth muscle cells from hypertensive rats: Protein kinase C-dependent and -independent mechanisms. Br J Pharmacol 117:41P, 1996 (abstr)
14. Rosskopf D, Dusing R, Siffert W: Membrane sodium-proton exchange and primary hypertension. Hypertension 21:607-617, 1993
15. + exchanger isoform 1 phosphorylation in normal Wistar-Kyoto and spontaneously hypertensive rats. Circ Res 76:825-831, 1995
16. + exchanger NHE-1 of vascular myocytes from Wistar-Kyoto and spontaneously hypertensive rats. Metabolism 45:114-119, 1996
17. + antiporter, a glycoprotein of 110 kD. Science 247:723-726, 1990
18. Anderson NG, Maller JL, Tonks NK, et al: Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature 343:651-653, 1990
19. Posada J, Cooper JA: Requirements for phosphorylation of MAP kinase during meiosis in Xenopus oocytes. Science 255:212-215, 1992
20. mapk by MAP kinase kinase, FEBS Lett 306:17-22, 1992
21. Robbins DJ, Cobb MH: Extracellular signal-regulated kinases autophosphorylate on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: Analysis by peptide mapping. Mol Biol Cell 3:299-308, 1992
22. 2+-dependent mitogenactivated protein kinase activation in spontaneously hypertensive rat vascular smooth muscle defines a hypertensive signal transduction phenotype. Circ Res 78:962-970, 1996
23. + exchanger in human platelets. Differential effect of phorbol ester and vasopressin. J Biol Chem 271:16494-16499, 1996
24. + exchanger isoform 1. Hypertension 27:859-866, 1996