Expression of P-glycoprotein and C-MOAT in human hepatocellular carcinoma detection by immunostaining

Digestive Diseases and Sciences

Volumn 47, Issue 11, 2002, Pages 2454-2458

  Richart, John ^a   Brunt, Elizabeth M ^a   Di Bisceglie, Adrian M ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Liver cancer; Multi drug resistance; Transport proteins

Indexed keywords

CARRIER PROTEIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 2;

ARTICLE; CLINICAL ARTICLE; DYSPLASIA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING;

ADENOMA; CARCINOMA, HEPATOCELLULAR; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN;

EID: 0036845842     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020543522417     Document Type: Article

References (10)

1. Schafer DF, Sorrell MF: Hepatocellular carcinoma. Lancet 353:1253-1257, 1999
2. Di Bisceglie AM: Malignant neoplasms of the liver. In ER Schiff, WC Maddrey, M Sorrell (eds). Schiff's Diseases of the Liver, 8th Ed. Philadelphia, Lippincott-Raven, 1999, pp 1281-1303
3. Fojo AT, Ueda K, Slamon DJ, Poplack DG, Gottesman MM, Pastan I: Expression of multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci USA 84:265-269, 1987
4. Trauner M, Meier PJ, Boyer JL: Mechanisms of disease: Molecular pathogenesis of cholestasis. N Engl J Med 339:1217-1227, 1998
5. Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. JNCI 90:1735-1741, 1998
6. International Working Party: Terminology of nodular hepatocellular lesions. Hepatology 22:983-993, 1995
7. Shen D-W, Lu Y-G, Chin K-V, Pastan I, Gottesman MM: Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MDR1 expression. J Cell Sci 98:317-322, 1991
8. Itsubo M, Ishikawa T, Toda G, Tanaka M: Immunohistochemical study of expression and cellular localization of the multidrug resistance gene product P-glycoprotein in primary liver carcinoma. Cancer 73:298-303, 1994
9. Nagasue N, Dhar DK, Makino Y, Yoshimura H, Nakamura T: Overexpression of P-glycoprotein in adenomatous hyperplasia of human liver with cirrhosis. J Hepatol 22:197-201, 1995
10. Takayama T, Makuuchi M, Hirohashi S, Sakamoto M, Okazaki N, Takayasu K, Kosuge T, Motoo Y, Yamazaki S, Hasegawa H: Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 336:1150-1153, 1990