Clinical xenotransplantation of solid organs

Lancet

Volumn 349, Issue 9055, 1997, Pages 867-871

  Dorling, Anthony ^a   Riesbeck, Kristian ^a   Warrens, Anthony ^a   Lechler, Robert ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT;

ALLOGRAFT; COMPLEMENT ACTIVATION; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; IMMUNITY; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; SHORT SURVEY; SWINE; XENOTRANSPLANTATION;

EID: 0030995163     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(96)09404-4     Document Type: Review

References (40)

1. Evans RW, Orians CE, Ascher NL. The potential supply of organ donors: an assessment of the efficacy of organ procurement efforts in the United States. JAMA 1992; 267: 239-46.
2. Nuffield Council on Bioethics. Animal-to-human transplants. London: Nuffield Foundation, 1996.
3. Advisory Group on the Ethics of Xenotransplantation. Animal tissue into humans. London: Stationery Office, 1997.
4. Patience C, Takeuchi Y, Weiss RA. Infection of human cells by an endogenous retrovirus of pigs. Nat Med 1997; 3: 282-86.
5. Bailey LL, Nehtseu-Canarella SL, Conepcion W, Joley WB. Baboon to human cardiac xenotransplantation in a neonate. JAMA 1985; 254: 3321.
6. Starzl TE, Fung J, Tsakis A, et al. Baboon-to-human liver transplantation. Lancet 1993; 341: 65-71.
7. Reemtsma K, McCracken B, Schlegel J, et al. Renal heterotransplantation in man. Ann Surg 1964; 160: 384-410.
8. Calne RY. Organ transplantation between widely disparate species. Transplant Proc 1970; II: 550-53.
9. Platt JL, Vercellotti GM, Dalmasso AP, et al. Transplantation of discordant xenografts: a review of progress. Immunol Today 1990; 11: 450-56.
10. Parker W, Saadi S, Lin SS, Holzknecht ZE, Bustos M, Platt JL. Transplantation of discordant xenografts: a challenge revisited. Immunol Today 1996; 17: 373-78.
11. Parker W, Lundberg-Swanson K, Holzknecht ZE, et al. Isohemagglutinins and xenoreactive antibodies: members of a distinct family of natural antibodies. Hum Immunol 1996; 45: 94-104.
12. Sandrin MS, Vaughan HA, Dabkowski PL, McKenzie IFC. Anti-pig IgM antibodies in human serum react predominantly with gal α(1-3)gal epitopes.Proc Natl Acad Sci USA 1993; 90: 11391-95.
13. Platt JL, Holzknecht ZE. Porcine platelet antigens recognized by human xenoreactive natural antibodies. Transplantation 1994; 57: 327-35.
14. Good AH, Cooper DKC, Malcolm AJ, et al. Identification of carbohydrate structures that bind human anti-porcine antibodies: implications for discordant xenografting in humans. Transplant Proc 1992; 24: 559.
15. Ye Y, Neethling FA, Niekrasz M, et al. Evidence that intravenously administered alpha-galactosyl carbohydrates reduce baboon serum cytotoxicity to pig kidney cells (PK15) and transplanted pig hearts. Transplantation 1994; 58: 330-37.
16. Sandrin MS, Fodor WL, Mouhtouris E, et al. Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis. Nat Med 1995; 1: 1261-67.
17. Koike C, Kannagi R, Takuma Y, et al. Introduction of α(1-2)-fucosyltransferase and its effect on αgal epitopes in transgenic pig. Xenotransplantation 1996; 3: 81-86.
18. Zhao J, Rollins SA, Maher JE, Bothwell ALM, Sims PJ. Amplified gene expression in CD59-transfected chinese hamster ovary cells confers protection against the membrane attack complex of human complement. J Biol Chem 1991; 266: 13418-22.
19. Cozzi E, White DJG: The generation of transgenic pigs as potential organ donors for humans. Nat Med 1995; 1: 964-66.
20. Diamond LE, McCurry KR, Martin MJ, et al. Characterization of transgenic pigs expressing functionally active human CD59 on cardiac endothelium. Transplantation 1996; 61: 1241-49.
21. McCurry KR, Kooyman DL, Alvarado CG, et al. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat Med 1995; 1: 423-27.
22. Rosengard AM, Gary NRB, Langford GA, Tucker AW, Wallwork J, White DJG. Tissue expression of human complement inhibitor, decay-accelerating factor, in transgenic pigs. Transplantation 1995; 59: 1325-33.
23. Fodor WL, Williams BL, Matis LA, et al. Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection. Proc Natl Acad Sci USA 1994; 91: 11153-57.
24. Thompson C. Humanised pigs hearts boost xenotransplantation. Lancet 1995; 346: 766.
25. Bach FH, Winkler H, Ferran C, Hancock WW, Robson SC. Delayed xenograft rejection. Immunol Today 1996; 17: 379-84.
26. Malyguine AM, Saadi S, Platt JL, Dawson JR. Human natural killer cells induce morphologic changes in porcine endothelial cell monolayers. Transplantation 1996; 61: 161-64.
27. Seebach JD, Yamada K, McMorrow IM, Sachs DH, DerSimonian H. Xenogeneic human anti-pig cytotoxicity mediated by activated natural killer cells. Xenotransplantation 1996; 3: 188-97.
28. Pierson RN, Winn HJ, Russell PS, Auchincloss H. Xenogeneic skin graft rejection is especially dependent on CD4+ T cells. J Exp Med 1989; 170: 991-96.
29. + T cell depleted diabetic mice. Transplantation 1990; 50: 657-62.
30. + or B lymphocytes, can reject xenogeneic skin grafts. Xenotransplantation 1994; 1: 8-16.
31. Wolf LA, Coulombe M, Gill RG. Donor antigen-presenting cell-independent rejection of islet xenografts. Transplantation 1995; 60: 1164-70.
32. Auchincloss H. Xenogeneic transplantation. Transplantation 1988; 46: 1-20.
33. Dorling A, Lombardi G, Binns R, Lechler RI. Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population. Eur J Immunol 1996; 26: 1378-87.
34. Dorling A, Binns R, Lechler RI. Cellular xenoresponses: observation of significant primary indirect human T cell anti-pig xenoresponses using co-stimulator-deficient or SLA class II-negative porcine stimulators. Xenotransplantation 1996; 3: 112-19.
35. Murray AG, Khodadoust MM, Pober JS, Bothwell ALM. Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity 1994; 1: 57-63.
36. Dorling A, Lechler RI. The passenger leukocyte, dendritic cell and antigen-presenting cells (APC). In: Tilney NL, Strom TB, Paul LC, eds. Transplantation Biology; Cellular and Molecular Aspects. Philadelphia: Lippincott-Raven; 1996.
37. Cooke SP, Hederer RA, Pearson JD, Savage COS. Characterization of human IgG-binding xenoantigens expressed by porcine aortic endothelial cells. Transplantation 1995; 60: 1274-84.
38. Johansson Borg A, Kumagai-Braesch M, Möller E. Effect of DSG on xenogeneic immune reactivity with special emphasis on human anti-pig cellular reactions in vitro. Xenotransplantation 1996; 3: 171-78.
39. Chapman LE, Folks TM, Salomon DR, Patterson AP, Eggerman TE, Noguchi PD. Xenotransplantation and xenogeneic infections. N Engl J Med 1995; 333: 1498-501.
40. Sachs DH, Sykes M, Greenstein JS, Cosimi AB. Tolerance and xenograft survival. Nat Med 1995; 1: 969.