Phase II study of continuous infusion carmustine and cisplatin followed by cranial irradiation in adults with newly diagnosed high-grade astrocytoma

Journal of Clinical Oncology

Volumn 15, Issue 7, 1997, Pages 2596-2603

  Grossman, Stuart A ^a   Wharam, Moody ^a   Sheidler, Vivian ^a   Kleinberg, Larry ^a   Zeltzman, Michel ^a   Yue, Nancy ^a   Piantadosi, Steven ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARMUSTINE; CISPLATIN;

ADULT; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASTROCYTOMA; CANCER COMBINATION CHEMOTHERAPY; CANCER GRADING; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; DRUG EFFICACY; GLIOBLASTOMA; HUMAN; MAJOR CLINICAL STUDY; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; SKULL IRRADIATION;

EID: 0030793974     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1997.15.7.2596     Document Type: Article

References (28)

1. Wingo PA, Tong T, Bolden S: Cancer statistics, 1995. CA Cancer J Clin 45:8-30, 1995
2. Grieg NH, Ries LG, Yancik R, et al: Increasing annual incidence of primary brain tumors in the elderly. J Natl Cancer Inst 82:1621-1624, 1990
3. Mao Y, Desmeules M, Semencio RM, et al: Increasing brain cancer rates in Canada. Can Med Assoc J 145:1583-1591, 1991
4. Ries LAG, Hankey BF, Miller BA, et al: Cancer statistics review 1973-88. NIH publication no. 91-2789, 1.31 VI. 44. Bethesda, MD, National Cancer Institute, 1991
5. Curran WJ, Scott CB, Horton J, et al: Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst 85:704-710, 1993
6. Walker MD, Alexander E, Jr, Hunt WE, et al: Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. J Neurosurg 49:333-343, 1978
7. Walker MD, Green SB, Byar DP et al: Randomized comparison of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 303:1323-1329, 1980
8. Fine HA, Dear BG, Loeffler JS, et al: Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 71:2285-2297, 1993
9. Inaba Y, Hiratsuka H, Komatsu K, et al: Sequential delayed enhanced CT in brain tumors. Neuroradiology 16:549-551, 1978
10. Norman D, Stevens EA, Wings SD, et al: Quantitative aspects of contrast enhancement in cranial computed tomography. Radiology 129:683-688, 1978
11. Grossman SA, Sheidler VR, Ahn H, et al: Complete and partial responses of newly diagnosed malignant astrocytomas (MA) following continuous infusion BCNU and cisplatin. Proc Am Soc Clin Oncol 8:344, 1989 (abstr)
12. Marcial-Vega VA, Wharam MD, Leibel S, et al: Treatment of supratentorial high grade gliomas with split course high fractional dose postoperative radiotherapy. Int J Radiat Oncol Biol Phys 16:1419-1424, 1989
13. Kleinberg L, Slick T, Enger C, et al: Short course radiotherapy is an appropriate option for the majority of glioma patients. Int J Radiat Biol Phys (in press)
14. Grossman SA, Sheidler VR, Gilbert MR: Decreased phenytoin levels in patients receiving chemotherapy: Report of a series and a review of the literature. Am J Med 87:505-510, 1989
15. Oka K, Tsuda H, Sakamoto S, et al: Plasminogen activator and hemorrhage in brain tumors. J Neurooncol 22:183-187, 1994
16. Kornblith PL, Walker M: Chemotherapy for malignant gliomas. J Neurosurg 86:1-17, 1988
17. Gilbert MR, Lunsford LK, Kondziolka L, et al: A phase II trial of continuous infusion chemotherapy, external beam radiotherapy and local boost radiotherapy. Proc Am Soc Clin Oncol 12:176, 1993 (abstr)
18. Fetell MR, Grossman SA, Belmaceda C, et al: Clinical and pharmacologic study of pre-irradiation paclitaxel in newly diagnosed patients with glioblastoma multiforme. Proc Am Soc Clin Oncol 13:179, 1994 (abstr)
19. Grossman SA, Burch PA: Quantitation of tumor response to anti-neoplastic therapy. Semin Oncol 15:441-454, 1988
20. Macdonald DR, Cascino TL, Schold SC, et al: Response critena for phase II studies of supratentorial malignant glioma. J Clin Oncol 8:1277-1290, 1990
21. Watling CJ, Lee DH, Macdonald DR, et al: Corticosteroid-induced magnetic resonance Imaging changes in patients with recurrent malignant glioma. J Clin Oncol 12:1886-1889, 1994
22. Grossman SA, Zeltzman M: Practical considerations in the management of patients with primary brain tumors. Neurologist 2:130-138, 1996
23. Thoron L, Arbit E: Hemostatic changes in patients with brain tumors. J Neurooncol 23:87-100, 1994
24. Hamilton MR, Hull RD, Pineo GF: Prophylaxis of venous thromboembolism in brain tumor patients. J Neurooncol 22:111-126, 1994
25. Norris LK, Grossman SA: Treatment of thromboembolic complications in patients with brain tumors. J Neurooncol 22:127-137, 1994
26. Ettinger DS: Evaluation of new drugs in untreated patients with small cell lung cancer: It's time has come. J Clin Oncol 8:374-377, 1990
27. Cairncross G, Macdonald D, Ludwin S, et al: Chemotherapy for anaplastic oligodendroglioma. J Clin Oncol 12:2013-2021, 1994
28. Grossman SA, Norris LK: Adjuvant and neoadjuvant treatment for primary brain tumors in adults. Semin Oncol 22:530-539, 1995