Opposites attract, or do they? Rethinking the P450 2D6 pharmacophore model

Trends in Pharmacological Sciences

Volumn 23, Issue 11, 2002, Pages 501-

  Gillam, Elizabeth M J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BUFURALOL; CYTOCHROME P450 2D6; NITROGEN; SPIROSULFONAMIDE; SULFONAMIDE; UNCLASSIFIED DRUG;

BINDING AFFINITY; CHEMICAL INTERACTION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; GENE; MUTATION; NOTE; OXIDATION; PH; PHARMACOPHORE; PRIORITY JOURNAL;

EID: 0036842295     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0165-6147(02)02121-1     Document Type: Note

References (1)

1. Guengerich, F.P. et al. (2002) Diversity in the oxidation of substrates by cytochrome P450 2D6: Lack of an obligatory role of aspartate 301-substrate electrostatic bonding. Biochemistry 10.1021/bi020341k