Interferon therapy does not prevent hepatocellular carcinoma in HCV compensated cirrhosis

Hepato-Gastroenterology

Volumn 49, Issue 48, 2002, Pages 1636-1638

  Testino, Gianni ^a   Ansaldi, Filippo ^a   Andorno, Enzo ^a   Ravetti, Gian Luigi ^a   Ferro, Carlo ^a   De Iaco, Fabio ^a   Icardi, Giancarlo ^a   Valente, Umberto ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Cirrhosis; Hepatitis C virus; Hepatocellular carcinoma; Interferon

Indexed keywords

ALANINE AMINOTRANSFERASE; INTERFERON; VIRUS RNA;

ADULT; ARTICLE; ASSAY; BLOOD TRANSFUSION; CANCER INCIDENCE; CANCER RISK; COHORT ANALYSIS; CONTROLLED STUDY; DATA ANALYSIS; DEATH; DETERIORATION; DEVICE; DRUG EFFECT; DRUG USE; ECHOGRAPHY; FEMALE; FOLLOW UP; HEPATITIS C VIRUS; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER INJURY; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; NEEDLE BIOPSY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEROTYPE; SIDE EFFECT; SPIRAL COMPUTER ASSISTED TOMOGRAPHY;

ALANINE TRANSAMINASE; ANTIVIRAL AGENTS; CARCINOMA, HEPATOCELLULAR; CHI-SQUARE DISTRIBUTION; FEMALE; HEPATITIS C, CHRONIC; HUMANS; INCIDENCE; INTERFERONS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; RNA, VIRAL;

EID: 0036840024     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. International Interferon-alpha Hepatocellular Carcinoma Study Group: Effect of interferon-alpha on progression of cirrhosis to hepatocellular carcinoma: a retrospective cohort study. Lancet 1998; 27:1535-1539.
2. Yoshida H, Shiratori Y, Moriyama M, Arakawa Y, Ide T, Sata M: Interferon therapy reduces the risk of hepatocellular carcinoma: natural surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. Ann Int Med 1999; 131:174-181.
3. Bvegnu' L, Chemello L, Noventa F, Fattowich G, Pontisso P, Alberti A: Retrospective analysis of the effect of Interferon therapy on the clinical outcome of patients with viral cirrhosis. Cancer 1998; 83:901-909.
4. Okanoue T, Itoh Y, Minami M, Sakamoto S, Yasui K, Sakamoto M: Interferon therapy lowers the rate of progression to hepatocellular carcinoma in chronic hepatitis C but not significantly in an advanced stage: a retrospective study in 1148 patients. Viral hepatitis therapy study. J Hepatol 1999; 30:653-659.
5. Perasso A, Testino G, Ansaldi F, Venturino V, Icardi GC: r-Interferon alfa-2b/ Ribavirin ed therapy followed by low-dose r-Interferon alfa-2b in chronic hepatitic C Interferon non-responders. Hepatology 1999; 29:296-297.
6. Imai Y, Kawata S, Tamura S, Yabuuchi I, Noda S, Inada M: Relation of Interferon therapy and hepatocellular carcinoma in patients with chronic hepatitic C. Ann Int Med 1998; 129:94-99.
7. Kowdley KV: Does Interferon therapy prevent hepatocellular carcinoma in patients with chronic hepatitic C? Gastroenterology 1999; 117:738-740.
8. Yamaguchi K, Omagari K, Kinoshita H, Yoshioka S, Furusu H, Takeshima F, Nanashima A, Yamaguchi H, Kohno S: Development of hepatocellular carcinoma in a patient with chronic hepatitis C after 6 years of a sustained and complete respons to IFN-alpha. J Clin Gastroenterol 1999; 29:207-209.
9. Kubo S, Nishiguchi S, Hirohashi K, Tanaka H, Shuto T, Yamazaki O: Effects of long-term postoperative Interferon-alpha therapy on intrahepatic recurrence after resection of hepatitic C virus-related hepatocellular carcinoma. Ann Int Med 2001; 134:963-967.
10. Testino G: Inteferon therapy in chronic hepatitis C virus in the prevention of worsening independently of ALT response: is it conceivable? Hepatogastroenterology 2001; 48:Letter.