Maternal insulin manipulation in rats organize body weight and noradrenergic innervation of the hypothalamus in gonadally intact male offspring

Developmental Brain Research

Volumn 97, Issue 1, 1996, Pages 16-21

  Jones, A P ^a   Olster, D H ^b   States, B ^a  

^a PITZER COLLEGE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Development; Differentiation; Dopamine hydroxylase; Insulin; Obesity; Paraventricular nucleus

Indexed keywords

DOPAMINE BETA MONOOXYGENASE; HUMAN INSULIN; INSULIN; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CASTRATION; CONTROLLED STUDY; DEVELOPMENT; FEMALE; IMMUNOCYTOCHEMISTRY; INTRAMUSCULAR DRUG ADMINISTRATION; LOCUS CERULEUS; MALE; NONHUMAN; NORADRENERGIC NERVE; PRIORITY JOURNAL; RAT; TESTOSTERONE BLOOD LEVEL; THALAMUS MIDLINE NUCLEUS; ANIMAL; BLOOD; CHEMISTRY; ENZYMOLOGY; FEEDING BEHAVIOR; FOREBRAIN; GONAD; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; NERVE TRACT; OBESITY; ORCHIECTOMY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; PRENATAL EXPOSURE; SPRAGUE DAWLEY RAT;

ANIMALIA;

ANIMALS; BODY WEIGHT; DOPAMINE BETA-HYDROXYLASE; FEEDING BEHAVIOR; FEMALE; GONADS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; INSULIN; MALE; NEURAL PATHWAYS; NOREPINEPHRINE; OBESITY; ORCHIECTOMY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030598387     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(96)00128-9     Document Type: Article

References (32)

1. [1] Adam, P.A., Teramo, K., Raiha, N., Gitlin, D. and Schwartz, R., Human fetal insulin metabolism in gestation, Diabetes, 18 (1969) 409-414.
2. [2] Baskin, D.G., Figlewicz, D.P., Woods, S.C., Porte, D. and Dorsa, D.M., Insulin in the brain, Annu. Rev. Physiol., 49 (1987) 347.
3. [3] Beretier, D.A. and Jeanrenaud, B., Altered dendritic orientation of hypothalamic neurons from genetically obese ob/ob mice, Brain Res., 202 (1980) 201-206.
4. [4] Boyd, F.T., Clarke, D.W., Murther, T.F. and Raizada, M.K., Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain, J. BM. Chem., 260 (1985) 15880-15884.
5. [5] Corbit, J.D. and Stellar, E., Palatability, food intake and obesity in normal and hyperphagic rats, J. Comp. Physiol. Psychol., 58 (1964) 63-67.
6. [6] Cooper, J.R., Bloom, F.E. and Roth, R.H., The Biochemical Basis of Neuropharmacology, Oxford University Press, New York, 1991.
7. [7] Dorner, G., Environment dependent brain differentiation and the fundamental processes of life, Acta Biol. Med. Germ., 33 (1974) 129-150.
8. [8] Figlewicz, D.P., Bentson, K. and Ocrant, I., The effect of insulin on norepinephrine uptake by PC 12 cells. Brain Res. Bull., 32 (1993) 425-431.
9. [9] Gorski, R.A., Influence of age on the response to paranatal administration of a low dose of androgen, Endocrinology, 82 (1968) 1001-1014.
10. [10] Ishii, D.N. and Recio-Pinto, E., Insulin in the brain, Neurochem. Int., 12 (1988) 397-415.
11. [11] Jones, A.P. and Friedman, M.I., Obesity and adipocyte abnormalities in the offspring of rats undernourished during pregnancy, Science, 215 (1982) 1518-1519.
12. [12] Jones, A.P., Simson, E.L. and Friedman, M.I., Gestational undernutrition and the development of obesity in rats, J. Nutr., 114 (1984) 1484-1492.
13. [13] Jones, A.P. and Crnic, L.S., Maternal metabolic response to gestational undernutrition and refeeding, Nutr. Behav., 3 (1986) 233-241.
14. [14] Jones, A.P., Assimon, S.A. and Friedman, M.I., Effect of a high-fat diet on obesity induced by gestational undernutrition, Physiol. Behav., 37 (1986) 381-386.
15. [15] Jones, A.P. and Dayries, M., Maternal hormone manipulations and the development of obesity in rats, Physiol. Behav., 47 (1990) 1107-1110.
16. [16] Jones, A.P., Pothos, E.N., Rada, P., Olster, D.H. and Hoebel, B.G., Maternal hormonal manipulations in rats cause obesity and increase medial hypothalamic norepinephrine release in male offspring, Dev. Brain Res., 88 (1995) 127-131.
17. [17] Kappy, M.S. and Raizada, M.K., Adult insulin binding is present in term fetal rat CNS membrane, Brain Res., 249 (1982) 390-392.
18. [18] Leibowitz, S.F. and Meyers, R.D., The neurochemistry of ingestion: chemical stimulation of the brain and in vivo measurement of transmitter release. In F.M. Toates and N.E. Rowland (Eds.), Feeding and Drinking, Elsevier, Amsterdam, 1987, pp. 271-315.
19. [19] McEwen, B., Neural gonadal steroid actions, Science, 211 (1981) 1303-1311.
20. [20] McGowan, M.K., Andrews, K.M., Kelly, J. and Grossman, S.P., Effects of chronic intrahypothalamic infusions of insulin on food intake and diurnal meal patterning in the rat, Behav. Neurosci., 104 (1990) 371-383.
21. [21] Orosco, M., Gerozissis, K., Rouch, C. and Nicolaidis, S., Feeding related immunoreactive insulin changes in the PVN-VMH revealed by microdialysis, Brain Res., 671 (1995) 149-158.
22. [22] Paez, X., Stanley, B.G. and Leibowitz, S.F., Microdialysis analysis of norepinephrine levels in the paraventricular nucleus in association with food intake at dark onset, Brain Res., 606 (1993) 167-170.
23. [23] Ravelli, G.P., Stein, A.A. and Susser, M., Obesity in young men after famine exposure in utero and early infancy, New Engl. J. Med., 295 (1976) 249-253.
24. [24] Sawchenko, P.E. and Swanson, L.W., The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat, Brain Res. Rev., 4 (1982) 275-325.
25. [25] Spellacy, W.N., Goetz, F.C., Greenburg, B.Z. and Ellis, J., The human placental gradient for plasma insulin and blood glucose, Am. J. Obstet. Gynecol., 90 (1964) 753-761.
26. [26] Sperling, M.A. and Gongul, S., Prenatal and postnatal development of insulin and glucagon receptors: potential role in energy storage and utilization, J Pediatr. Gastroenterol. Nutr., Suppl. 1, 2 (1983) S46-S51.
27. [27] Strubbe, J.H. and Mein, C.G., Intrahypothalamic infusions of insulin antibodies induce feeding in rats, Physiol. Behav., 19 (1977) 309-315.
28. [28] Swanson, L.W. and Hartman, B.K., The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-β-hydroxylase as a marker, J. Comp. Neurol., 163 (1975) 467-506.
29. [29] Toran-Allerand, C.D., Ellis, L. and Pfenninger, K.H., Estrogen and insulin synergism in neurite outgrowth enhancement in vitro: mediation of steroid effects by interactions with growth factors? Dev. Brain Res., 41 (1988) 87-100.
30. [30] Watson, R.E., Wiegand, S.J., Clough, R.W. and Hoffman, G.E., Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology, Peptides, 7 (1986) 155-159.
31. [31] Woods, S.C., Lotter, E.C., McKay, D. and Porte, D., Chronic intracerebroventricular infusions of insulin reduces food intake and body weight in baboons, Nature, 282 (1979) 503-505.
32. [32] Young, J.K., Nance, D.M. and Gorski, R.A., Sexual dimorphism in the regulation of caloric intake and body weight of rats fed different diets, Physiol. Behav., 23 (1979) 577-582.