Pharmacological management of early rheumatoid arthritis - Does combination therapy improve outcomes?

Journal of Rheumatology

Volumn 29, Issue SUPPL. 66, 2002, Pages 20-26

  Dougados, Maxime ^a   Smolen, Josef S ^a  

^a Department of Rheumatology B ^*  (France)

Author keywords

Combination therapy; Disease modifying antirheumatic drugs; Rheumatoid arthritis; Treatment

Indexed keywords

ANTIRHEUMATIC AGENT; DISEASE MODIFYING ANTIRHEUMATIC DRUG; GLUCOCORTICOID; HYDROXYCHLOROQUINE; METHOTREXATE; PREDNISOLONE; SALAZOSULFAPYRIDINE; UNCLASSIFIED DRUG;

BONE DEFECT; BONE DESTRUCTION; CONFERENCE PAPER; DIAGNOSTIC ACCURACY; DISEASE ACTIVITY; DISEASE COURSE; DRUG EFFICACY; ECONOMIC ASPECT; HUMAN; META ANALYSIS; METHODOLOGY; PREVALENCE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; TREATMENT OUTCOME; CLINICAL TRIAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG COMBINATION; PATHOLOGY; PATHOPHYSIOLOGY; REVIEW;

ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CLINICAL TRIALS; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; HUMANS; TREATMENT OUTCOME;

EID: 0036833533     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (27)

1. Buckley CD. Science, medicine, and the future: Treatment of rheumatoid arthritis. BMJ 1997;315:236-8.
2. Emery P, Breedveld FC, Dougados M, Kalden JR, Schiff MH, Smolen JS. Early referral recommendation for newly diagnosed rheumatoid arthritis: evidence based development of a clinical guide. Ann Rheum Dis 2002;61:290-7.
3. King R. Rheumatoid Arthritis. eMedicine Journal Internet 2002; [Cited April 5, 2002]; available from http://www.emedicine.com/emerg/topic48.htm.
4. Mottonen TT, Hannonen PJ, Boers M. Combination DMARD therapy including corticosteroids in early rheumatoid arthritis. Clin Exp Rheumatol 1999; 17 Suppl:S59-65.
5. Bingham S, Emery P. Combination therapy in rheumatoid arthritis. Springer Semin Immunopathol 2001;23:165-83.
6. Garrood T, Scott DL. Combination therapy with disease modifying anti-rheumatic drugs in rheumatoid arthritis. BioDrugs 2001;15:543-61.
7. Goekoop YP, Allaart CF, Breedveld FC, Dijkmans BA. Combination therapy in rheumatoid arthritis. Curr Opin Rheumatol 2001;13:177-83.
8. Quinn MA, Conaghan PG, Emery P. The therapeutic approach of early intervention for rheumatoid arthritis: What is the evidence? Rheumatology 2001;40:1211-20.
9. Wilske KR, Healey LA. Remodeling the pyramid - A concept whose time has come. J Rheumatol 1989;16:565-7.
10. Boers M. Combination treatment in autoimmune diseases. Methodology of combination trials. Springer Semin Immunopathol 2001;23:27-33.
11. Green M, Marzo-Ortega H, McGonagle D, et al. Persistence of mild, early inflammatory arthritis: The importance of disease duration, rheumatoid factor, and the shared epitope. Arthritis Rheum 1999;42:2184-8.
12. Bathon JM, Martin RW, Fleischmann RM, et al. A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N Engl J Med 2000;343:1586-93.
13. Felson DT, Anderson JJ, Meenan RF. The efficacy and toxicity of combination therapy in rheumatoid arthritis. A meta-analysis. Arthritis Rheum 1994;37:1487-91.
14. Boers M, Verhoeven AC, Markusse HM, et al. Randomised comparison of combined step-down prednisolone, methotrexate and sulfasalazine with sulfasalazine alone in early rheumatoid arthritis. Lancet 1997;350:309-18.
15. Landewe RB, Boers M, Verhoeven AC, et al. COBRA combination therapy in patients with early rheumatoid arthritis: Long-term structural benefits of a brief intervention. Arthritis Rheum 2002;46:347-56.
16. Dougados M, Combe B, Cantagrel A, et al. Combination therapy in early rheumatoid arthritis: A randomised, controlled, double blind 52 week clinical trial of sulfasalazine and methotrexate compared with the single components. Ann Rheum Dis 1999;58:220-5.
17. Haagsma CJ, van Riel PL, de Jong AJ, van de Putte LB. Combination of sulfasalazine and methotrexate versus the single components in early rheumatoid arthritis: A randomized, controlled, double-blind, 52 week clinical trial. Br J Rheumatol 1997; 36:1082-8.
18. Mottonen T, Hannonen P, Leirisalo-Repo M, et al. Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: A randomised trial. FIN-RACo trial group. Lancet 1999;353:1568-73.
19. Proudman SM, Conaghan PG, Richardson C, et al. Treatment of poor-prognosis early rheumatoid arthritis. A randomized study of treatment with methotrexate, cyclosporin A, and intraarticular corticosteroids compared with sulfasalazine alone. Arthritis Rheum 2000;43:1809-19.
20. Marchesoni A, Battafarano N, Arreghini M, Panni B, Cagnoli M, Tosi S. Slower radiographic progression in patients with early rheumatoid arthritis treated with cyclosporine and methotrexate combination therapy [abstract]. Arthritis Rheum 2001;44 Suppl:S371.
21. O'Dell JR, Haire CE, Erikson N, et al. Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications. N Engl J Med 1996;334:1287-91.
22. Haagsma CJ, van Riel PL, de Rooij DJ, et al. Combination of methotrexate and sulfasalazine vs methotrexate alone: A randomized open clinical trial in rheumatoid arthritis patients resistant to sulfasalazine therapy. Br J Rheumatol 1994; 33:1049-55.
23. Manna SK, Mukhopadhyay A, Aggarwal BB. LEF suppresses TNF-induced cellular responses: Effects on NF-kappa B, activator protein-1. c-Jun N-terminal protein kinase, and apoptosis. J Immunol 2000;165:5962-9.
24. Boers M. The case for corticosteroids in the treatment of early rheumatoid arthritis. Rheumatology 1999;38:95-7.
25. Anderson JJ, Wells G, Verhoeven AC, Felson DT. Factors predicting response to treatment in rheumatoid arthritis: The importance of disease duration. Arthritis Rheum 2000;43:22-9.
26. Lard LR, Visser H, Speyer I, et al. Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: Comparison of two cohorts who received different treatment strategies. Am J Med 2001;111:446-51.
27. Nell VPK, Machold KP, Eberl G, Uffman M, Slamm T, Smolen JS. Benefits of very early referral and therapy with disease modifying antirheumatic drugs in patients with early rheumatoid arthritis. Annual European Congress of Rheumatology EULAR 2002, Stockholm, Sweden, June 12-15, 2002. Abstract OP0012; [cited July 30, 2002]. available at http://www.eular.org/eular2002/abstracts_direct.cfm.