Severity of alcohol withdrawal symptoms and the T1128c polymorphism of the neuropeptide Y gene

Journal of Neural Transmission

Volumn 109, Issue 11, 2002, Pages 1423-1429

  Koehnke, M D ^a   Schick, S ^a   Lutz, U ^a   Willecke, M ^a   Koehnke, A M ^a   Kolb, W ^b   Gaertner, I ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b Wilhelmsheim Hospital   (Germany)

Author keywords

Addiction; Alcohol; Delirium; Neuropeptide Y; Polymorphism; Seizure; Withdrawal

Indexed keywords

NEUROPEPTIDE Y; CYSTEINE; THREONINE;

ADULT; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; DELIRIUM TREMENS; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; STATISTICAL ANALYSIS; ALLELE; CASE CONTROL STUDY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HOSPITALIZATION; MIDDLE AGED; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; WITHDRAWAL SYNDROME;

ADULT; ALCOHOL WITHDRAWAL DELIRIUM; ALCOHOLISM; ALLELES; CASE-CONTROL STUDIES; CYSTEINE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NEUROPEPTIDE Y; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SEVERITY OF ILLNESS INDEX; SUBSTANCE WITHDRAWAL SYNDROME; THREONINE;

EID: 0036831019     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00702-002-0752-1     Document Type: Article

References (24)

1. Albers HE, Ferris CF (1984) Neuropeptide Y: role in light-dark cycle entrainment of hamster circadian rhythms. Neurosci Lett 50: 163-168
2. th ed. American Psychiatric Press, Washingtion, DC
3. Badia-Elder NE, Stewart RB, Powrozek TA, Roy KF, Murphy JM, Li TK (2001) Effect of neuropeptide Y (NPY) on oral ethanol intake in Wistar, alcohol-preferring (P), and -nonpreferring (NP) rats. Alcohol Clin Exp Res 25: 386-390
4. Carr LG, Foroud T, Bice P, Gobbett T, Ivashina J, Edenberg H, Lumeng L, Li TK (1998) A quantitative trait locus for alcohol consumption in selectively bred rat lines. Alcohol Clin Exp Res 22: 884-887
5. Clark JT, Kalra PS, Crowley WR, Kalra SP (1984) Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115: 427-429
6. Cockerill M (1998) Low levels of brain chemicals drives mice to drink. Br Med J 317: 1544
7. Cubells JF, Kobayashi K, Nagatsu T, Kidd KK, Kidd JR, Calafell F, Kranzler HR, Ichinose H, Gelernter J (1997) Population genetics of a functional variant of the dopamine beta-hydroxylase gene (DBH). Am J Med Genet 74: 374-379
8. Ehlers CL, Li TK, Lumeng L, Hwang BH, Somes C, Jimenez P, Mathe AA (1998) Neuropeptide Y levels in ethanol-naive alcohol-preferring and nonpreferring rats and in Wistar rats after ethanol exposure. Alcohol Clin Exp Res 22: 1778-1782
9. Gray TS, Morley J (1986) Neuropeptide Y: anatomical distribution and possible function in mammalian nervous system. Life Sci 38: 389-401
10. Heilig M, Soderpalm B, Engel JA, Widerlov E (1989) Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology (Berl) 98: 524-529
11. Hwang BH, Zhang JK, Ehlers CL, Lumeng L, Li TK (1999) Innate differences of neuropeptide Y (NPY) in hypothalamic nuclei and central nucleus of the amygdala between selectively bred rats with high and low alcohol preference. Alcohol Clin Exp Res 23: 1023-1030
12. Karvonen MK, Pesonen U, Koulu M, Niskanen L, Laakso M, Rissanen A, Dekker JM, Hart LM, Valve R, Uusitupa MI (1998) Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels. Nat Med 4: 1434-1437
13. Kauhanen J, Karvonen MK, Pesonen U, Koulu M, Tuomainen TP, Uusitupa MI, Salonen JT (2000) Neuropeptide Y polymorphism and alcohol consumption in middle-aged men. Am J Med Genet 93: 117-121
14. Leibowitz SF (1991) Brain neuropeptide Y: an integrator of endocrine, metabolic and behavioral processes. Brain Res Bull 27: 333-337
15. Levine AS, Morley JE (1984) Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides 5: 1025-1029
16. Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 16: 1215
17. Okubo T, Harada S (2001) Polymorphism of the neuropeptide Y gene: an association study with alcohol withdrawal. Alcohol Clin Exp Res 25: 59S-62S
18. Pich EM, Agnati LF, Zini I, Marrama P, Carani C (1993) Neuropeptide Y produces anxiolytic effects in spontaneously hypertensive rats. Peptides 14: 909-912
19. Roy A, Berrettini W, DeJong J, Adinoff B, Ravitz B, Linnoila M (1990) CSF neuropeptide Y in alcoholics and normal controls. Psychiatry Res 33: 215-219
20. Schuckit MA, Tipp JE, Reich T, Hesselbrock VM, Bucholz KK (1995) The histories of withdrawal convulsions and delirium tremens in 1648 alcohol dependent subjects. Addiction 90: 1335-1347
21. Sullivan JT, Sykora K, Schneiderman J, Naranjo CA, Sellers EM (1989) Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar). Br J Addict 84: 1353-1357
22. Thiele TE, Marsh DJ, Ste-Marie L, Bernstein IL, Palmiter RD (1998) Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature 396: 366-369
23. Vezzani A, Sperk G, Colmers WF (1999) Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci 22: 25-30
24. Wittchen HU, Zaudig M, Fydrich T (1997) SKID. Strukturiertes Klinisches Interview fuer DSM-IV. Users guide for the Structured Clinical Interview for DSM-IV, modified version [Original: First MB, Gibbon M, Spitzer RL, Williams JBW (1996) SCID-I; SCID-II]. Testzentrale, Robert-Bosch-Breite 25, D-37079 Goettingen