An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives. Structure-activity comparative studies with isomeric pyrroloquinolines

European Journal of Pharmaceutical Sciences

Volumn 17, Issue 3, 2002, Pages 139-143

  Vlachou, Margarita ^a   Tsotinis, Andrew ^a   Kelland, Lloyd R ^b   Thurston, David E ^c  

^a UNIVERSITY OF ATHENS   (Greece)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Cytotoxic activity; Pyrroloisoquinolines; Pyrroloquinolines; Synthesis

Indexed keywords

ALKYLATION; BIOLOGICAL ORGANS; CELLS; ISOMERS; TOXICITY;

OVARIAN CELL LINES;

DRUG PRODUCTS;

1 (2 MORPHOLIN 1 YLETHYL) 1H PYRROLO[2,3 F]ISOQUINOLINE; 1 (2 PIPERIDIN 1 YLETHYL) 1H PYRROLO[2,3 F]ISOQUINOLINE; 1 (2 PYRROLIDIN 1 YLETHYL) 1H PYRROLO[2,3 F]ISOQUINOLINE; 5 NITROISOQUINOLINE; BROMINE DERIVATIVE; ETHYLAMINE; ISOQUINOLINE DERIVATIVE; N,N DIETHYL(2 PYRROLO[2,3 F]ISOQUINOLIN 1 YL)ETHYLAMINE; N,N DIMETHYL(2 PYRROLO[2,3 F]ISOQUINOLIN 1 YL)ETHYLAMINE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VINYLMAGNESIUM BROMIDE; ISOQUINOLINE; PYRROLE DERIVATIVE;

ALKYLATION; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SELECTIVITY; DRUG SYNTHESIS; EVALUATION; FEMALE; HUMAN; HUMAN CELL; ISOMER; OVARY CELL CULTURE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECT; ISOMERISM; PHYSIOLOGY; SYNTHESIS;

FEMALE; HUMANS; ISOMERISM; ISOQUINOLINES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0036830626     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(02)00163-X     Document Type: Article

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