Hox cluster polarity in early transcriptional availability: A high order regulatory level of clustered Hox genes in the mouse

Mechanisms of Development

Volumn 119, Issue 1, 2002, Pages 81-90

  Roelen, Bernard A J ^a   De Graaff, Wim ^a   Forlani, Sylvie ^a   Deschamps, Jacqueline ^a  

^a HUBRECHT INSTITUTE   (Netherlands)

Author keywords

Mouse Hox genes during gastrulation; Retinoid signalling and transcriptional initiation of the Hox genes; Transcriptional regulation of the Hox genes

Indexed keywords

HOX PROTEIN; HOXB1 PROTEIN; HOXB2 PROTEIN; RETINOIC ACID; UNCLASSIFIED DRUG; 5 BROMO 4 CHLORO 3 INDOLYL BETA GALACTOSIDE; 5-BROMO-4-CHLORO-3-INDOLYL BETA-GALACTOSIDE; CDX1 PROTEIN, HUMAN; CDX1 PROTEIN, MOUSE; GALACTOSIDE; HOMEODOMAIN PROTEIN; HOXB1 HOMEODOMAIN PROTEIN; HOXB2 PROTEIN, MOUSE; INDOLE DERIVATIVE; MESSENGER RNA; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; TRANSCRIPTION INITIATION; ANIMAL; C57BL MOUSE; CBA MOUSE; CHROMATIN; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; IN SITU HYBRIDIZATION; LACTOSE OPERON; METABOLISM; TIME; TRANSGENE;

ANIMALS; CHROMATIN; GALACTOSIDES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; INDOLES; LAC OPERON; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSGENES; TRETINOIN;

EID: 0036830226     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(02)00329-5     Document Type: Article

References (44)

1. Beck F., Erler T., Russel A., James R. Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes. Dev. Dyn. 204:1995;219-227.
2. Becker D., Jiang Z., Knodler P., Deinard A.S., Eid R., Kidd K.K., Shashikant C.S., Ruddle F.H., Schughart K. Conserved regulatory element involved in the early onset of Hoxb6 gene expression. Dev. Dyn. 205:1996;73-81.
3. Bel-Vialar S., Coré N., Terranova R., Goudot V., Boned A., Djabali M. Altered retinoic acid sensitivity and temporal expression of Hox genes in Polycomb-M33-deficient mice. Dev. Biol. 224:2000;238-249.
4. Bhattacharrya N., Dey A., Minucci S., Zimmer A., John S., Hager G., Ozato K. Retinoid-induced chromatin structure alterations in the retinoic acid receptor beta2 promoter. Mol. Cell. Biol. 17:1997;6481-6490.
5. Brooke N.M., Garcia-Fernàndez J., Holland P.W.H. The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster. Nature. 392:1998;920-922.
6. Charité J., de Graaff W., Consten D., Reijnen M.J., Korving J., Deschamps J. Transducing positional information to the Hox genes: critical interaction of cdx gene products with position-sensitive regulatory elements. Development. 125:1998;4349-4358.
7. Charité J., de Graaff W., Shen S.B., Deschamps J. Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures. Cell. 78:1994;589-601.
8. Charité J., de Graaff W., Vogels R., Meylink F., Deschamps J. Regulation of the Hoxb-8 gene: synergism between multimerized cis-acting elements increases responsiveness to positional information. Dev. Biol. 171:1995;294-305.
9. Chawengsaksophak K., James R., Hammond V.E., Kontgen F., Beck F. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature. 386:1997;84-87.
10. Conlon R.A., Rossant J. Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo. Development. 116:1992;357-368.
11. Deschamps J., Wijgerde M. Two phases in the establishment of HOX expression domains. Dev. Biol. 156:1993;473-480.
12. Deschamps J., van den Akker E., Forlani S., de Graaff W., Oosterveen T., Roelen B., Roelfsema J. Initiation, establishment and maintenance of Hox gene expression patterns in the mouse. Int. J. Dev. Biol. 43:1999;635-650.
13. Downs K.M., Davies T. Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope. Development. 118:1993;1255-1266.
14. Duboule D. The vertebrate limb: a model system to study the Hox/HOM gene network during development and evolution. Bioessays. 14:1992;375-384.
15. Duboule D. Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony. Development. Suppl. 1994;135-142.
16. Frohman M.A., Boyle M., Martin G.R. Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm. Development. 110:1990;589-607.
17. Gamer L.W., Wright C.V.E. Murine Cdx-4 bears striking similarities to the Drosophila caudal gene in its homeodomain sequence and early expression pattern. Mech. Dev. 43:1993;71-81.
18. Gould A., Itasaki N., Krumlauf R. Initiation of rhombomeric Hoxb4 expression requires induction by somitez and a retinoid pathway. Neuron. 21:1998;39-51.
19. Graham A., Papalopulu N., Lorimer J., McVey J.H., Tuddenham E.G.D., Krumlauf R. Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene. Genes Dev. 2:1988;1424-1438.
20. Houle M., Prinos P., Iulianella A., Bouchard N., Lohnes D. Retinoic acid regulation of Cdx1: an indirect mechanism for retinoids and vertebral specification. Mol. Cell. Biol. 20:2000;6579-6586.
21. Huang D., Chen S.W., Langston A.W., Gudas L.J. A conserved retinoic acid responsive element in the murine Hoxb-1 gene is required for expression in the developing gut. Development. 125:1998;3235-3246.
22. James R., Erler T., Kazenwadel J. Structure of the murine homeobox gene cdx-2. J. Biol. Chem. 269:1994;15229-15237.
23. Kmita M., van der Hoeven F., Zákány J., Krumlauf R., Duboule D. Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex. Genes Dev. 14:2000;198-211.
24. Kondo T., Duboule D. Breaking colinearity in the mouse HoxD complex. Cell. 97:1999;407-417.
25. Kwan C.T., Tsang S.L., Krumlauf R., Sham M.H. Regulatory analysis of the mouse Hoxb3 gene: multiple elements work in concert to direct temporal and spatial patterns of expression. Dev. Biol. 232:2001;176-190.
26. Maconochie M.K., Nonchev S., Studer M., Chan S.K., Popperl H., Sham M.H., Mann R.S., Krumlauf R. Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1. Genes Dev. 11:1997;1885-1895.
27. Manzanares M., Bel-Vialar S., Ariza-McNaughton L., Ferretti E., Marshall H., Maconochie M.M., Blasi F., Krumlauf R. Independent regulation of initiation and maintenance phases of Hoxa3 expression in the vertebrate hindbrain involve auto- and cross-regulatory mechanisms. Development. 128:2001;3595-3607.
28. Marshall H., Nonchev S., Sham M.H., Muchamore I., Lumsden A., Krumlauf R. Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity. Nature. 360:1992;737-741.
29. Marshall H., Studer M., Pöpperl H., Aparicio S., Kuroiwa A., Brenner S., Krumlauf R. A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1. Nature. 370:1994;567-571.
30. Meyer B.I., Gruss P. Mouse Cdx-1 expression during gastrulation. Development. 117:1993;191-203.
31. Murphy P., Davidson D.R., Hill R.E. Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain. Nature. 341:1989;156-159.
32. Niederreither K., Subbarayan V., Dollé P., Chambon P. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat. Genet. 21:1999;444-448.
33. Prinos P., Joseph S., Oh K., Meyer B.I., Gruss P., Lohnes B. Multiple pathways governing Cdx1 expression during murine development. Dev. Biol. 239:2001;257-269.
34. Rubock M.J., Larin Z., Cook M., Papalopulu N., Krumlauf R., Lehrach H. A yeast artificial chromosome containing the mouse homeobox cluster Hox-2. Proc. Natl. Acad. Sci. USA. 87:1990;4751-4755.
35. Schughart K., Utset M.F., Awgulewitsch A., Ruddle F.H. Structure and expression of Hox-2.2, a murine homeobox-containing gene. Proc. Natl. Acad. Sci. USA. 85:1988;5582-5586.
36. Sham M.H., Hunt P., Nonchev S., Papalopulu N., Graham A., Boncinelli E., Krumlauf R. Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distribution in the nervous system and the potential for shared regulatory regions. EMBO J. 11:1992;1825-1836.
37. Studer M., Gavalas A., Marshall H., Ariza-McNaughton L., Rijli P.M., Chambon P., Krumlauf R. Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning. Development. 125:1998;1025-1036.
38. Studer M., Popperl H., Marshall H., Kuroiwa A., Krumlauf R. Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1. Science. 265:1994;1728-1732.
39. Subramanian V., Meyer B.I., Gruss P. Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell. 83:1995;641-653.
40. Van den Akker E., Forlani S., Chawengsaksophak K., de Graaff W., Beck F., Meyer B., Deschamps J. Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation. Development. 129:2002;2181-2193.
41. Van der Hoeven F., Zákány J., Duboule D. Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls. Cell. 85:1996;1025-1035.
42. Wilkinson D.G., In Situ Hybridization, a Practical Approach. 1992;IRL Press, New York, NY.
43. Wilkinson D.G., Bhatt S., Cook M., Boncinelli E., Krumlauf R. Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain. Nature. 341:1989;405-409.
44. Zhang F., Nagy Kovacs E., Featherstone M.S. Murine Hoxd4 expression in the CNS requires multiple elements including a retinoic acid response element. Mech. Dev. 96:2000;79-89.