Vaginal melanoma: A clinicopathologic and immunohistochemical study of 26 cases

American Journal of Surgical Pathology

Volumn 26, Issue 11, 2002, Pages 1450-1457

  Gupta, Deepali ^a   Malpica, Anais ^a   Deavers, Michael T ^a   Silva, Elvio G ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

HMB 45; Immunohistochemistry; MART 1; Melanoma; Microphthalmia transcription factor; S 100; Tumors; Tyrosinase; Vagina

Indexed keywords

MELAN A; MONOPHENOL MONOOXYGENASE; PROTEIN S 100; TRANSCRIPTION FACTOR;

ADULT; AGED; ARTICLE; BRAIN METASTASIS; CLINICAL ARTICLE; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE DISSECTION; MELANOMA; MICROPHTHALMIA; PROGNOSIS; TUMOR RECURRENCE; VAGINA BLEEDING; VAGINA DISEASE; VAGINA TUMOR;

ADULT; AGED; AGED, 80 AND OVER; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MELANOMA; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; TUMOR MARKERS, BIOLOGICAL; VAGINAL NEOPLASMS;

EID: 0036828007     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200211000-00007     Document Type: Article

References (35)

1. Allen CA, Spitz S. Malignant melanoma: A clinicopathologic analysis of the criteria for diagnosis and prognosis. Cancer 1953;6:1-45.
2. Batsakis JG, Suarez P. Mucosal melanomas: A review. Adv Anat Pathol 2000;7:167-80.
3. Blessing K, Sanders DS, Grant JJ. Comparison of immunohistochemical staining of the novel antibody melan-A with S100 protein and HMB-45 in malignant melanoma and melanoma variants. Histopathology 1998;32:139-46.
4. Borazjani G, Prem KA, Okagaki T, et al. Primary malignant melanoma of the vagina: A clinico-pathologic analysis of 10 cases. Gynecol Oncol 1990;37:264-7.
5. Brand E, Fu YS, Lagasse LD, et al. Vulvovaginal melanoma: A report of seven cases and literature review. Gynecol Oncol 1989;33:54-60.
6. Busam KJ, Chen YT, Old LJ, et al. Expression of melan-A (MART1) in benign melanocytic nevi and primary cutaneous malignant melanoma. Am J Surg Pathol 1998;22:976-82.
7. Chen YT, Stockert E, Tsang S, et al. Immunophenotyping of melanomas for tyrosinase: Implications for vaccine development. Proc Natl Acad Sci USA 1995;29;92:8125-9.
8. Chung A, Casey MJ, Flannery JT, et al. Malignant melanoma of the vagina: Report of 19 cases. Obstet Gynecol 1980;55:720-7.
9. Chung AF, Woodruff JM, Lewis JL. Malignant melanoma of the vulva: A report of 44 cases. Obstet Gynecol 1975;45:638-46.
10. Cobellis L. Calabrese E, Stefanon B. et al. Malignant melanoma of the vagina: A report of 15 cases. Eur J Gynaecol Oncol 2000;21:295-7.
11. DeMatos P, Tyler D, Seigler HF. Mucosal melanomas of the female genitalia: A clinico-pathologic study of forty-three cases at Duke University Medical Center. Surgery 1998;124:38-48.
12. Ferrer J, Zapatero HA, Coto LP, et al. Vaginal melanoma: Report of two cases and review of the literature. Eur J Gynaecol Oncol 1995;16:190-4.
13. Gonzalez-Bosquet J, Garcia Jimenez A, Gil Moreno A, et al. Malignant vulvo-vaginal melanoma: A report of 7 cases. Eur J Gynaecol Oncol 1997;18:63-7.
14. Granter SR, Weilbaecher KN, Quigley C, et al. Microphthalmia transcription factor: Not a sensitive or specific marker for the diagnosis of desmoplastic melanoma and spindle cell (non-desmoplastic) melanoma. Am J Dermatopathol 2001;23:185-9.
15. Hacker NF. Vulvar cancer. In: Berek JS, Adashi EY, Hillard PA, eds. Novak's Gynecology, 12th Ed. Baltimore: Williams & Wilkins, 1996:1231-59.
16. Hatch KD, Fu YS. Cervical and vaginal cancers. In: Berek JS, Adashi EY, Hillard PA, eds. Novak's Gynecology, 12th Ed. Baltimore: Williams & Wilkins, 1996:1111-53.
17. Hemesath TJ, Steingrimsson E, McGill G, et al. Microph1thalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev 1994;8:2770-80.
18. Hofbauer GF, Kamarashev J, Geertsen R. et al. Tyrosinase immunoreactivity in formalin-fixed, paraffin-embedded primary and metastatic melanoma: Frequency and distribution. J Cutan Pathol 1998;25:204-9.
19. Hsu S, Raine L, Fanger H. The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. Am J Clin Pathol 1981;75:816-21.
20. Jentys W, Sikorowa L, Mokrzanowski A. Primary melanoma of the vagina: Clinicopathologic study of 7 cases. Oncology 1975;31:83-91.
21. Jungbluth AA, Iversen K, Coplan K, et al. Expression of melanocyte-associated markers gp-100 and Melan-A/MART-1 in angiomyolipomas: An immunohistochemical and RT-PCR analysis. Virchows Arch 1999;434:429-35.
22. King R, Googe PB, Weilbaecher KN, et al. Microphthalmia transcription factor expression in cutaneous benign, malignant melanocytic, and nonmelanocytic tumors. Am J Surg Pathol 2001;25:51-7.
23. Koch MB, Shih IM, Weiss SW, et al. Microphthalmia transcription factor and melanoma cell adhesion molecule expression distinguish desmoplastic/spindle cell melanoma from morphologic mimics. Am J Surg Pathol 2001;25:58-64.
24. Levitan Z, Gordon AN, Kaplan AL, et al. Primary malignant melanoma of the vagina: A report of four cases and review of the literature. Gynecol Oncol 1989;33:85-90.
25. Longacre TA, Egbert BM, Rouse RV. Desmoplastic and spindlecell malignant melanoma: An immunohistochemical study. Am J Surg Pathol 1996;20:1489-500.
26. Nakhleh RE, Wick MR, Rocamora A, et al. Morphologic diversity in malignant melanomas. Am J Clin Pathol 1990;93:731-40.
27. Nigossyan G, De La Pava S, Pickeren JW. Melanoblasts in vaginal mucosa: Origin for primary malignant melanoma. Cancer 1964;17:912-3.
28. Parker SL, Tong T, Bolden S, et al. Cancer statistics, 1997. CA Cancer J Clin 1997;47:5-27.
29. Prasad ML, Jungbluth AA, Iversen K, et al. Expression of melanocytic differentiation markers in malignant melanomas of the oral and sinonasal mucosa. Am J Surg Pathol 2001:25:782-7.
30. Scambia G, Benedetti Panici P, Baiocchi G, et al. A primary amelanotic melanoma of the vagina diagnosed by immunocytochemistry. Int J Gynaecol Obstet 1989;29:159-64.
31. Stellato G, Iodice F, Casella G, et al. Primary malignant melanoma of the vagina: Case report. Eur J Gynaecol Oncol 1998;19:186-8.
32. Takahashi K, Isobe T, Ohtsuki Y, et al. Immunohistochemical study on the distribution of alpha and beta subunits of S-100 protein in human neoplasm and normal tissues. Virchows Arch B Cell Pathol Mol Pathol 1984;45:385-96.
33. Vanstapel MJ, Gatter KC, de Wolf-Peeters C, et al. New sites of human S-100 immunoreactivity detected with monoclonal antibodies. Am J Clin Pathol 1986;85:160-8.
34. Weinstock MA. Malignant melanoma of the vulva and vagina in the United States: Patterns of incidence and population-based estimates of survival. Am J Obstet Gynecol 1994;171:1225-30.
35. Yasumoto K, Yokoyama K, Shibata K, et al. Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. Mol Cell Biol 1994;14:8058-70.