Vincristine-itraconazole interaction: Cause for increasing concern [1]

Journal of Pediatric Hematology/Oncology

Volumn 24, Issue 7, 2002, Pages 591-

  Sathiapalan, Rajeev K ^a   Al Nasser, Abdallah ^a   EI Solh, Hassan ^a   Al Mohsen, Ibrahim ^a   Al Jumaah, Sulaiman ^a  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; FLUCONAZOLE; ITRACONAZOLE; VINCRISTINE;

ABDOMINAL DISTENSION; ACUTE LYMPHOBLASTIC LEUKEMIA; CANDIDIASIS; CASE REPORT; CHILD; CONSTIPATION; HUMAN; HYPERTENSION; HYPONATREMIA; INAPPROPRIATE VASOPRESSIN SECRETION; LETTER; MALE; NEUROTOXICITY; OLIGURIA; PRIORITY JOURNAL; SERUM OSMOLALITY; SWEATING; THORAX PAIN; URINE OSMOLALITY;

EID: 0036817999     PISSN: 10774114     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043426-200210000-00023     Document Type: Letter

References (6)

1. Bohme A, Ganser A, Hoelzer D. Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL. Ann Hematol 1995;71: 311-2.
2. Gilles J, Hung KA, Fitzimons E, et al. Severe vincristine toxicity in combination with itraconazole. Clin Lab Haematol 1998;20:123-4.
3. Murphy JA, Ross LM, Gibson BES. Vincristine toxicity in five children with acute lymphoblastic leukemia. Lancet 1995;346:443.
4. Sathiapalan RK, El-Solh H. Enhanced vincristine neurotoxicity from drug interactions: Case report and review of literature. Pediatr Hematol Oncol 2001;18:543-6.
5. Jeng, MR, Feusner, J. Itraconazole-enhanced vincristine neurotoxicity in a child with acute lymphoblastic leukemia. Pediatr Hematol Oncol 2001;18:137-42.
6. Fedeli L, Colozza M, Boschetti E, et al. Pharmacokinetics of vincristine in cancer patients treated with nifedipine. Cancer 1989:64:1805-11.