The adverse renal effects of prostaglandin-synthesis inhibition in the fetus and the newborn

Paediatrics and Child Health

Volumn 7, Issue 8, 2002, Pages 538-543

  Drukker, Alfred ^a,b  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b HEBREW UNIVERSITY   (Israel)

Author keywords

COX inhibition; Fetus; Newborn; NSAIDs; Renal development; Renal function

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; IBUPROFEN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN DERIVATIVE;

4 AMINOHIPPURIC ACID CLEARANCE; ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; DRUG EFFECT; FETUS; FETUS DEVELOPMENT; GLOMERULUS FILTRATION RATE; HUMAN; HYDRAMNIOS; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; KIDNEY VASCULAR RESISTANCE; MORTALITY; NEPHROTOXICITY; NEWBORN; NONHUMAN; OLIGURIA; PERINATAL PERIOD; PREMATURE LABOR; PRENATAL EXPOSURE; PROSTAGLANDIN SYNTHESIS INHIBITION; RABBIT; REVIEW; TOXEMIA; VASOCONSTRICTION; VASODILATATION;

EID: 0036814844     PISSN: 12057088     EISSN: None     Source Type: Journal    
DOI: 10.1093/pch/7.8.538     Document Type: Review

References (32)

1. Heymann MA, Rudolph MA, Silverman NH. Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. N Engl J Med 1976;295:530-3.
2. Salame Chama N, Mosig D, Drukker A, Guignard JP. The renal hemodynamic effects of ibuprofen in the newborn rabbit. Pediatr Res 2000;48:600-5.
3. Drukker A, Mosig D, Guignard JP. The renal hemodynamic effects of aspirin in newborn and young adult rabbits. Pediatr Nephrol 2001;16:713-8.
4. Sneader W. The discovery of aspirin: A reappraisal. BMJ 2000;321:1591-4.
5. Piper PJ, Vane JR. Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature 1969;223:29-35.
6. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 1971;231:232-5.
7. DeWitt DL, Smith WL. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc Natl Acad Sci USA 1988;85:1412-6.
8. Masferrer JL, Zweifel BS, Seibert K, Needleman P. Selective regulation of cellular cyclooxygenase by dexamethasone and endoxin in mice. J Clin Invest 1990;86:1375-9.
9. Xie W, Chipman JG, Robertson DL, Erikson RL, Simmons DL. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 1991;88:2692-6.
10. Harris RC. Cyclooxygenase-2 in the kidney. J Am Soc Nephrol 2000;11:2387-94.
11. Harris RC. Macula densa signalling - A potential role of cyclogenase-2. Nephrol Dial Transpl 2000;15:1504-6.
12. Castrop H, Schweda F, Schumacher K, Wolf K, Kurtz A. Role of renocortical cyclooxygenase-2 for renal vascular resistance and macula densa control of renin secretion. J Am Soc Nephrol 2001;12:867-74.
13. Toth-Heyn P, Drukker A, Guignard JP. The stressed neonatal kidney. Pediatr Nephrol 2000;14:227-39.
14. Cuzzolin L, Dal-Cere M, Fanos-V. NSAID-induced nephrotoxicity from the fetus to the child. Drug Safety 2001;24:9-18.
15. Burrow ChR. Regulatory molecules in kidney development. Pediatr Nephrol 2000;14:240-53.
16. Ichikawa I, Kuwayama F, Pope JC IV, Stephens FD, Miyazaki Y. Paradigm shift from classical anatomic theories to contemporary cell biological views of CAKUT (congenital anomalies of the kidneys and urinary tract). Kidney Int 2002;61:889-98.
17. Kömhoff M, Gröne H-J, Klein Th, Seyberth HW, Nusing RM. Localization of cyclooxygenase-1 and -2 in adult and fetal human kidney: Implication for renal function. Am J Physiol (Renal Physiol 41) 1997;272:F460-8.
18. Zhang M-Z, Wang J-L, Cheng H-F, Harris RC, McKanna JA. Cyclooxygenase-2 in rat nephron development. Am J Physiol (Renal Physiol 42) 1997;273:F994-1002.
19. Kömhoff M, Wang J-L, Cheng H-F, et al. Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development. Kidney Int 2000;57:414-22.
20. Norwood V, Morham SG, Smithies O. Postnatal development and progression of renal dysplasia in cyclooxygenase-2 null mice. Kidney Int 2000;58:2291-300.
21. Novy MJ. Effects of indomethacin on labor, fetal oxygenation and fetal development in rhesus monkeys. Adv Prostaglandins Thromboxane Res 1978;4:285-300.
22. Matson JR, Stokes JB, Robillard JE. Effects of inhibition of prostaglandin synthesis on fetal renal function. Kideny Int 1981;20:621-27.
23. Kaplan BS, Restaino 1, Raval DS, Gottlieb RP, Bernstein J. Renal failure in the neonate associated with in utero exposure to non-steroidal antiinflammatory agents. Pediatr Nephrol 1994;8:700-4.
24. van der Heijden BJ, Carlus C, Narcy F, Bavoux F, Delezoide A-L, Gubler M-C. Persistent anuria, neonatal death and renal microcystic lesions after prenatal exposure to indomethacin. Am J Obstet Gynecol 1994;171:617-23.
25. Peruzzi L, Gianoglio B, Porcellini MG, Coppo R. Neonatal end-stage renal failure associated with maternal ingestion of cyclo-oxygenase-type-1 selective inhibitor nimesulide as tocolytic. Lancet 1999;354:1615.
26. in t'Veld BA, Ruitenberg A, Hofman A, et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 2001;345:1515-21.
27. Whelton A. Nephrotoxicity of non-steroidal anti-inflammatory drugs: Physiologic foundations and clinical implications. Am J Med 1999;106(5B):13S-24S.
28. Brater DC. Effects of nonsteroidal anti-inflammatory drugs on renal function: Focus on cyclooxygenase-2-selective inhibition. Am J Med 1999;107(6A):65S-71S.
29. Van Overmeire B, Smets K, Lecoutere D, et al. A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus. N Engl J Med 2000;343:674-81.
30. Dani C, Bertini G, Reali MF, et al. Prophylaxis of patent ductus arteriosus with ibuprofen in preterm infants. Acta Paediatr 2001;83:1369-74
31. Drukker A, Guignard JP. Ibuprofen-lysine for closure of patent ductus arteriosus. Acta Paediatr Scand 2001;90:465. (Lett)
32. Vermillion ST, Landen CN Jr. Prostaglandins inhibitors as tocolytic agents. Seminars Perinatology 2001;25:256-62.