Effects of tenuiorin and methyl orsellinate from the lichen Peltigera leucophlebia on 5-/15-lipoxygenases and proliferation of malignant cell lines in vitro

Phytomedicine

Volumn 9, Issue 7, 2002, Pages 654-658

  Ingolfsdottir K ^a   Gudmundsdottir G F ^a   Ogmundsdottir H M ^b   Paulus, K ^c   Haraldsdottir S ^b   Kristinsson, H ^d   Bauer, R ^e  

^a UNIVERSITY OF ICELAND   (Iceland)

^b ICELANDIC CANCER SOCIETY   (Iceland)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d ICELANDIC INSTITUTE OF NATURAL HISTORY   (Iceland)

^e UNIVERSITY OF GRAZ   (Austria)

Author keywords

15 lipoxygenase; 5 lipoxygenase; Antiproliferation; Lichen; Methyl orsellinate; Peltigera leucophlebia; Tenuiorin

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; ORCINOL; ORSELLINIC ACID METHYL ESTER; PELTIGERA LEUCOPHLEBIA; PLANT EXTRACT; TENUIORIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; COLON CANCER; DRUG EFFECT; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; LEUKOCYTE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; SOYBEAN; SWINE;

GLYCINE MAX; PELTIGERA; PELTIGERA LEUCOPHLEBIA; SUIDAE; SUS SCROFA;

EID: 0036813212     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1078/094471102321616481     Document Type: Article

References (19)

1. Gissurarson SR, Sigurdsson SB, Wagner H, Ingólfsdóttir K (1997) Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea-pig taenia coli. J Pharm Exp Ther 280 (2): 770-773
2. Holtan-Hartwig J (1993) The lichen genus Peltigera exclusive of the P. canina group, in Norway. Sommerfeltia 15: 3-77
3. Huneck S, Yoshimura I (1996) Identification of Lichen Substances. Springer Verlag, Berlin, Heidelberg, pp 493
4. Ingólfsdóttir K, Bloomfield SF, Hylands PJ (1985) In vitro evaluation of the antimicrobial activity of lichen metabolites as potential preservatives. Antimicr Agents Chemother 28 (2): 289-292
5. Ingólfsdóttir, K, Breu W, Huneck S, Gudjonsdottir GA, Wagner H (1994) In vitro inhibition of 5-lipoxygenase by protolichesterinic acid from Cetraria islandica. Phytomedicine 1: 187-191
6. Ingólfsdóttir K, Gissurarson SR, Müller-Jakic B, Breu W, Wagner H (1996) Inhibitory effects of the lichen metabolite lobaric acid on arachidonate 5-lipoxygenase in vitro. Phytomedicine 2 (3): 243-246
7. Ingólfsdóttir K, Wiedemann B, Birgisdóttir M, Nenninger A, Jónsdóttir S, Wagner H (1997) Inhibitory effects of baeomycesic acid from the lichen Thamnolia subuliformis on 5-lipoxygenase in vitro. Phytomedicine 4 (2): 125-128
8. Kristinsson H (1964) Íslenskar engjaskófir. Flóra 2: 65-76
9. Krog H, Osthagen H, Tonsberg T (1994) Lavflora, Norske Busk-og Bladlav. Universitetsforlaget, Oslo, pp 368
10. Kumar KCS, Müller K (1999a) Lichen metabolites. 1. Inhibitory action against leukotriene B4 biosynthesis by a non-redox mechanism. J Nat Prod 62: 817-820
11. Kumar KCS, Müller K (1999b) Lichen metabolites. 2. Antiproliferative and cytotoxic activity of gyrophoric, usnic and diffractaic acid on human keratinocyte growth. J Nat Prod 62: 821-823
12. Lyckander IM, Malterud KE (1992) Lipophilic flavonoids from Orthosiphon spicatus as inhibitors of 15-lipoxygenase. Acta Pharm Nord 4: 159-166
13. Narui T, Sawada K, Takatsuki S, Okuyama T, Culberson CF, Culberson WL, Shibata S (1998) NMR assignments of depsides and tridepsides of the lichen family Umbilicariaceae. Phytochemistry 48(5): 815-822
14. Ögmundsdóttir H, Zoëga GM, Gissurarson SR, Ingólfsdóttir K (1998) Anti-proliferative effects of lichen-derived inhibitors of 5-lipoxygenase on malignant cell lines and mitogen-stimulated lymphocytes. J Pharm Pharmacol 50(1): 107-115
15. Paulus K, Bauer R (2002) An Improved 5-lipoxygenase Assay in Microtiter Scale for the Screening of Herbal Drugs. Phytomedicine submitted
16. Perez-Llano GA (1944) Lichens. Their biological and economical significance. Bot Rev 10: 27-40
17. Steele VE, Holmes CA, Hawk ET, Kopelovich L, Lubet RA, Crowell JA, Sigman CC, Kelloff GJ (1999) Lipoxygenase inhibitors as potential cancer chemopreventives. Cancer Epidemiol Biomarkers Prev 8: 467-483
18. Steele VE, Holmes CA, Hawk ET, Kopelovich L, Lubet RA, Crowell JA, Sigman CC, Kelloff GJ (2000) Potential use of lipoxygenase inhibitors for cancer chemoprevention. Expert Opin Inv Drug 9(9): 2121-2138
19. Vartia KO (1950) On the medicinal use of lichens. Academic dissertation. Helsinki: 11-21