Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine: Part 3. Synthesis and pharmacological activity of 1-aryl-5,6(1H)dioxo-2,3-dihydroimidazo[1,2-a]imidazoles

European Journal of Medicinal Chemistry

Volumn 37, Issue 10, 2002, Pages 845-853

  Matosiuk, Dariusz ^a   Fidecka, Sylwia ^a   Antkiewicz Michaluk, Lucyna ^b   Dybala, Izabela ^c   Koziol, Anna E ^c  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

Author keywords

1 Aryl 5,6(1H)dioxo 2,3 dihydroimidazo 1,2 a imidazoles; 5 HT2 receptor recognition pharmacophore model; CNS activity; Molecular structures; Serotonergic activity

Indexed keywords

5 HYDROXYTRYPTOPHAN; ANTIDEPRESSANT AGENT; BENZODIAZEPINE RECEPTOR; CLONAZEPAM; DIAZEPAM; FLUNITRAZEPAM; IMIDAZOLE DERIVATIVE; IMIDAZOLIDINE DERIVATIVE; KETANSERIN; MORPHINE DERIVATIVE; MU OPIATE RECEPTOR; NALOXONE; RADIOLIGAND; SEROTONIN; SEROTONIN 2 RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR; NARCOTIC ANALGESIC AGENT; SEROTONIN RECEPTOR; SEROTONIN RECEPTOR AFFECTING AGENT;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BEHAVIOR; BINDING ASSAY; CENTRAL NERVOUS SYSTEM; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HEAD TWITCH; HOT PLATE TEST; HYDROGEN BOND; LD 50; MALE; MOUSE; NONHUMAN; SEROTONINERGIC SYSTEM; WRITHING TEST; ANIMAL; BINDING COMPETITION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; HEAT; MOTOR ACTIVITY; PAIN ASSESSMENT; RADIOASSAY; REACTION TIME; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

5-HYDROXYTRYPTOPHAN; ANALGESICS, OPIOID; ANIMALS; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HEAT; IMIDAZOLES; LETHAL DOSE 50; MICE; MOTOR ACTIVITY; PAIN MEASUREMENT; RADIOLIGAND ASSAY; REACTION TIME; RECEPTORS, GABA-A; RECEPTORS, OPIOID, MU; RECEPTORS, SEROTONIN; SEROTONIN AGENTS;

EID: 0036809058     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)01407-1     Document Type: Article

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