Detection of inhaled clenbuterol in horse urine by GC/MS2

Biomedical Chromatography

Volumn 16, Issue 7, 2002, Pages 475-481

  Van Eenoo, P ^a   Delbeke, F T ^a   Deprez, P ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; MASS SPECTROMETERS;

AIRWAY OBSTRUCTION; ALKALINES; BORONATES; CLENBUTEROL; DERIVATIZATIONS; DETECTION TIME; HORSE URINE; LIQUID-LIQUID EXTRACTION; NEBULISATION; PROPERTY;

MASS SPECTROMETRY;

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BORONIC ACID DERIVATIVE; CLENBUTEROL;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DRUG STRUCTURE; DRUG URINE LEVEL; FEMALE; GAS CHROMATOGRAPHY; HORSE; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; METHODOLOGY; NEBULIZATION; NONHUMAN; QUANTITATIVE ANALYSIS; URINALYSIS; URINE PH; VALIDATION PROCESS;

EQUIDAE; EQUUS CABALLUS;

EID: 0036807977     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.188     Document Type: Article

References (20)

1. Amendola L, Colamonici C, Rossi F and Botré F. Determination of clenbuterol in human urine by GC-MS-MS-MS-MS: confirmation analysis in antidoping control. Journal of Chromatography B 2002; 773: 7-16.
2. Biancotto G, Angeletti R, Piro R, Favretto D and Traldi PJMS. Ion trap high-performance liquid chromatography/multiple mass spectrometry in the determination of β-agonists in bovine urines. Journal of Mass Spectrometry 1997; 32: 781-784.
3. Biancotto G, Angeletti R. Traldi P and Guidugli F. Positive chemical ionization and tandem mass spectrometric fragmentation for the gas chromatographic analysis of β-agonists using the ion trap technique. Journal of Mass Spectrometry 1999; 34: 1346-1353.
4. Bressolle F, Bromet-Petit M and Audran M. Validation of liquid and gas chromatographic methods. Applications to pharmacokinetics. Journal of Chromatography B 1996: 686: 3-10.
5. 2-agonists by gas chromatography-mass spectrometric, analysis. Journal of Mass Spectrometry 2000; 35: 1285-1294.
6. Duvivier DH, Votion D, Vandeput S and Lekeux P. Aerosol therapy in the equine species. The Veterinary Journal 1997; 154: 189-202.
7. Harkins JD, Woods WE, Lehner AF, Fisher M and Tobin T. Clenbuterol in the horse: urinary concentrations determined by ELISA and GC/MS after clinical doses. Journal of Veterinary Pharmacology Therapeutics 2001; 24: 7-14.
8. IFHA. International Agreement on Breeding and Racing and Appendixes. January 2002.
9. International Laboratory Accreditation Cooperation, Accreditation requirements and operating criteria for horse racing laboratories, ILAC-G7, www.ilac.org/, 1996.
10. IOC. List of prohibited substances, January 2002.
11. Miller MF, Garcia DK, Coleman ME, Ekeren PA, Lunt DK, Wagner KA, Procknor M, Welsh TH Jr and Smith SIB. Adipose tissue, longissimus muscle and anterior pituitary growth and function in clenbuterol-fed heifers. Animal Science 1988; 66: 12-20.
12. Neogen Corporation. Elisa Racing Kit Manual. 2000.
13. Sams R. (1998). Medication case reports. Association of Official Racing. Chemists, 1998.
14. SANCO/1805/2000. Draft Commission Decision laying down performance criteria for the analytical methods to be used for detecting certain substances and residues thereof in live animal and animal products according to Council Directive 96/23/EC repealing Commission Decision 90/515/EC, 93/256/EC and 93/257/EC, 18 July 2000.
15. Sasse HI and Hajer R. NAB 365, a beta 2-receptor sympathomimetic agent: clinical experiende in horses with lung disease. Journal of Vetinary Pharmacology Therapy 1978; 1: 241-244.
16. Scott JS, Berney CE, Derksen FJ and Robinson NE. Beta-adrenergic-receptor activity in ponies with recurrent obstructive pulmonary disease. American Journal of Veterinary Research 1991; 52: 1416-1422.
17. Van Vyncht G, Preece P, Gaspar P, Maghuin-Rogister G and De Pauw E. Gas and Liquid chromatography coupled to tandem mass spectrometry for the multiresidue analysis of β-agonists in biological matrices. Journal of Chromatography A 1996; 750: 43-49.
18. 2-agonists in urine by gas chromatography-mass spectrometry for application in doping control. Analytica Chimica Acta 2000; 418: 79-92.
19. Votion D, Ghafir Y, Munsters K, Duvivier DH. Art T and Lekeux. Aerosol deposition in equine lungs following ultrasonic nebulisation versus jet aerosol delivery system. P. Equine Veterinary Journal 1997; 29: 388-393.
20. Verwaal W, van Bavel M, Boot A, Bravenboer J, de Goei F, Maas C and van der Putten A. Validatie van methoden. De Ware(n) Chemicus 1996; 26: 106.