Hepatocellular carcinoma with an unusual medullary-like histology and signs of regression (“medullary-like hepatocellular carcinoma”)

Digestive and Liver Disease

Volumn 34, Issue 10, 2002, Pages 748-753

  Zimmermann, A ^a   Kappeler, A ^a   Friess, H ^a   Buchler M W ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Hepatocellular carcinoma; Medullary carcinoma; Medullary like hepatocellular carcinoma

Indexed keywords

BETA CATENIN; FAS ANTIGEN; FAS LIGAND; PROTEIN S 100;

ADULT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CANCER REGRESSION; CANCER SURVIVAL; CARCINOMA CELL; CASE REPORT; CELL COMMUNICATION; CELL DAMAGE; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LYMPHOCYTIC INFILTRATION; MALE; PLASMA CELL; PROTEIN EXPRESSION; STELLATE CELL; T LYMPHOCYTE;

CARCINOMA, HEPATOCELLULAR; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM REGRESSION, SPONTANEOUS;

EID: 0036807925     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1590-8658(02)80027-5     Document Type: Article

References (31)

1. Ishak KG, Anthony PP, Sobin LH. Histological typing of tumours of the liver. Second Edition, International histological classification of tumours, World Health Organization. Berlin: Springer Verlag; 1994.
2. Nakashima T, Kojiro M. Hepatocellular carcinoma. An atlas of its pathology. Tokyo: Springer Verlag; 1987.
3. Yoshikawa J, Matsui O, Takashima T, Ida M, Takanaka T, Kawamura I, et al. Fatty metamorphosis in hepatocellular carcinoma: radiologic features in 10 cases. Am J Roentgenol 1988;151:717-20.
4. Zanconati F, Falconieri G, Lamovec J, Zidar A. Small cell carcinoma of the liver: a hitherto unreported variant of hepatocellular carcinoma. Histopathology 1996;29:449-53.
5. Sasaki A, Yokoyama S, Nakayama I, Nakashima K, Kim YI, Kitano S. Sarcomatoid hepatocellular carcinoma with osteoclast-like giant cells: case report and inummohistochemical observations. Pathol Int (Australia) 1997;47:318-24.
6. Ikebe T, Wakasa K, Sasaki M, Hamba H, Kaneko M, Yamamoto T, et al. Hepatocellular carcinoma with chondrosarcomatous variation: case report with immunohistochemical findings, and review of the literature. J Hepatobiliary Pancreat Surg 1998;5:217-20.
7. Akasofu M, Kawahara E, Kaji K, Nakanishi I. Sarcomatoid hepatocellular-carcinoma showing rhabdomyoblastic differentiation in the adult cirrhotic liver. Virchows Arch 1999;434:511-5.
8. Yamagata M, Masaki T, Okudaira T, Imai Y, Shiina S, Shiratori Y, et al. Small hyperechoic nodules in chronic liver diseases include hepatocellular carcinomas with low cyclin D1 and Ki-67 expression. Hepatology 1999;30:1722-9.
9. Ridolfi RL, Rosen PP, Port A, Kinne D, Miké V. Medullary carcinoma of the breast. A clinicopathologic study with 10 year follow-up. Cancer 1977;40:1365-85.
10. Wargotz ES, Silverberg SG. Medullary carcinoma of the breast: A clinicopathologic study with appraisal of current diagnostic criteria. Hum Pathol 1988;19:1340-6.
11. Ledesma S, Boada L, Tito L, Armengol S, Torres M. Spontaneous regression of hepatocellular carcinoma. Gastroenterol Hepatol 1998;21:469-70.
12. Stoelben E, Koch M, Hanke S, Lossnitzer A, Gaertner HJ, Schentke KU, et al. Spontaneous regression of hepatocellular carcinoma confirmed by surgical specimen: report of two cases and review of the literature. Langenbecks Arch Surg 1998;383:447-52.
13. Jang TJ, Lee JI, Kim DH, Kim JR, Lee HK. Spontaneous regression of hepatocellular carcinoma - a case report. Korean J Intern Med 2000;15:145-50.
14. Gaffey MJ, Joyce JP, Carlson GS, Esteban JM. Spontaneous regression of hepatocellular carcinoma. Cancer 1990;65:2779-83.
15. Toyoda H, Sugimura S, Fukuda K, Mabuchi T. Hepatocellular carcinoma with spontaneous regression of multiple lung metastases. Pathol Int 1999;49:893-7.
16. Rummeny E, Weissleder R, Sironi S, Stark DD, Comptom CC, Hahn PF, et al. Central scars in primary liver tumors: MR features, specificity, and pathologic correlation. Radiology 1989;171:323-6.
17. Kotlan B, Gruel N, Zaftani B, Furedi G, Foldi J, Petranyi GG, et al. Immunoglobulin variable regions usage by B-lymphocytes infiltrating a human breast medullary carcinoma. Immunol Lett 1999;65:143-51.
18. Wada Y, Nakashima O, Kutami R, Yamamoto O, Kojiro M. Clinicopathological study on hepatocellular carcinoma with lymphocytic infiltration. Hepatology 1998;27:407-14.
19. Emile JF, Adam R, Sebagh M, Marchadier E, Falissard B, Dussaix E, et al. Hepatocellular carcinoma with lymphoid stroma: a tumour with good prognosis after liver transplantation. Histopathology 2000;37:523-9.
20. Ito Y, Matsuura N, Sakon M, Takeda T, Umeshita K, Nagano H, et al. Both cell proliferation and apoptosis significantly predict shortened disease survival in hepatocelluar carcinoma. Br J Cancer 1999;81:747-51.
21. Cai L, Wang GJ, Xu ZL, Deng DX, Chakrabarti S, Cherian MG. Metallothionein and apoptosis in primary human hepatocellular carcinoma (HCC) from Northern China. Anticancer Res 1998;18:4667-72.
22. Feng D, Zheng H, Chen R, Yan Y. Study on relationship between apoptosis and proliferation of cells in liver cirrhosis and hepatocellular carcinoma. Hunan I Ko Ta Hsueh Hsueh Pao 1998;23:120-2.
23. Takehara T, Hayashi N. Fas and Fas ligand in human hepatocellular carcinoma. J Gastroenterol 2001;36:727-8.
24. Roskams T, Libbrecht L, Van Damme B, Desmet V. Fas and Fas ligand: strong co-expression in human hepatocytes surrounding hepatocellular carcinoma; can cancer induce suicide in peritumoral cells? J Pathol 2000;191:150-3.
25. Fukuzawa Y, Takahashi K, Furuta K, Tagaya T, Ishikawa T, Wada K, et al. Expression of Fas/Fas ligand (FasL) and its involvement in infiltrating lymphocytes in hepatocellular carcinoma (HCC). J Gastroenterol 2001;36:681-8.
26. Lee SH, Shin MS, Lee HS, Bae JH, Lee HK, Kim HS, et al. Expression of Fas and Fas-related molecules in human hepatocellular carcinoma. Hum Pathol 2001;32:250-6.
27. Strand S, Hofmann WJ, Hug H, Muller M, Otto G, Strand D, et al. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells: a mechanism of immune evasion? Nat Med 1996;2:1361-6.
28. Kajiwara M, Toyoshima S, Yao T, Tanaka M, Tsuneyoshi M. Apoptosis and cell proliferation in medullary carcinoma of the breast: a comparative study between medullary and non-medullary carcinoma using the TUNEL method and immunohistochemistry. J Surg Oncol 1999;70:209-16.
29. Yakirevich E, Maroun L, Cohen O, Izhak OB, Rennert G, Resnick MB. Apoptosis, proliferation, and Fas (APO-1, CD95)/Fas ligand expression in medullary carcinoma of the breast. J Pathol 2000;192:166-73.
30. De La Coste A, Romagnolo B, Billuart P, Renard CA, Buendia MA, Soubrane O, et al. Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci 1998;95:8847-51.
31. Endo K, Ueda T, Ueyama J, Ohta T, Terada T. Immunoreactive E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin proteins in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, and patients' survival. Hum Pathol 2000;31:558-65.