Activation of extracellular signal regulated kinase 1/2 in human dermal microvascular endothelial cells stimulated by anti-endothelial cell antibodies in sera of patients with Behçet's disease

Journal of Dermatological Science

Volumn 30, Issue 1, 2002, Pages 63-72

  Lee, Kwang Hoon ^a   Cho, Heun Jung ^a   Kim, Hong Suk ^a   Lee, Won Jae ^a   Lee, Sungnack ^b   Bang, Dongsik ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Ajou University School of Medicine   (South Korea)

Author keywords

Antibodies; Beh et's disease; Endothelial cells; ERK 1 2; ICAM 1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; AMIDE; ANTIBODY; ANTIGEN; ENDOTHELIAL CELL ANTIBODY; IMMUNOGLOBULIN M; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTI-ENDOTHELIAL CELL ANTIBODY; AUTOANTIBODY; INTERLEUKIN 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3;

ARTICLE; BEHCET DISEASE; CELL CULTURE; CELL DIFFERENTIATION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DERMIS; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; INFLAMMATION; MICROVASCULATURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERUM; SIGNAL TRANSDUCTION; SKIN CELL; VASCULITIS; WESTERN BLOTTING; BLOOD; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MICROCIRCULATION; PHYSIOLOGY; REFERENCE VALUE; SKIN; VASCULAR ENDOTHELIUM; VASCULARIZATION;

AUTOANTIBODIES; BEHCET SYNDROME; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1; MICROCIRCULATION; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; REFERENCE VALUES; RNA, MESSENGER; SKIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036803352     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-1811(02)00062-2     Document Type: Article

References (23)

1. Ghate J.V., Jorizzo J.L. Behçet's disease and complex aphthosis. J. Am. Acad. Dermatol. 40:1999;1-18.
2. Bang D., Yoon K.H., Chung H.G., Choi E.H., Lee E.S., Lee S. Epidemiological and clinical features of Behçet's disease in Korea. Yonsei Med. J. 38:1997;428-436.
3. Bang D., Honma T., Saito T., Nakagawa S., Ueki H., Lee S. The pathogenesis of vascular change in erythema nodosum-like lesions of Behçet's disease: an electron microscopic study. Hum. Pathol. 18:1987;1172-1179.
4. Bang D., Honma T., Saito T., Nakagawa S., Ueki H., Lee S. Ultrastructure of vascular changes in cutaneous manifestations of Behçet's disease. Acta Derm. Venereol. (Stockh.). 68:1988;33-40.
5. Savage C.O.S., Cooke S.P. The role of the endothelium in systemic vasculitis. J. Autoimmun. 6:1993;237-249.
6. Jorrizzo J.L., Hudson R.D., Schmalstieg F.C., Daniels J.C., Apisarnthanarax P., Henry J.C., et al. Behçet's syndrome immune regulation, circulating immune complexes, neutrophil migration, and colchicine therapy. J. Am. Acad. Dermatol. 10:1984;205-214.
7. Osborn L. Leukocyte adhesion to endothelium in inflammation. Cell. 62:1990;3-6.
8. Lee K.H., Bang D., Choi E.S., Chun W.H., Lee E.S., Lee S. Detection of circulating antibodies to cultured human dermal microvascular endothelial cells and their relation with cytolysis to endothelial cells in patients with Behçet's disease. Arch. Dermatol. Res. 291:1999;374-381.
9. Lee K.H., Chung H.S., Bang D., Lee S. Behçet's disease sera containing antiendothelial cell antibodies promote adhesion of T lymphocytes to cultured human dermal microvascular endothelial cells. Yonsei Med. J. 40:1999;152-158.
10. Tamura D.Y., Moore E.E., Johnson J.L., Zallen G. P38 mitogen-activated protein kinase inhibition attenuates intercellular adhesion molecule-1 up-regulation on human pulmonary microvascular endothelial cells. Surgery. 124:1998;403-407.
11. Pietersma A., Tilly B.D., Gaestel M., deJong N. P38 mitogen activated protein kinase regulated endothelial VCAM-1 expression at the post-transcriptional level. Biochem. Biophys. Res. Commun. 230:1997;44-48.
12. International Study Group for Behçets Disease . Criteria for diagnosis of Behçet's disease. Lancet. 335:1990;1078-1080.
13. Kubota Y., Kleinman H., Martin G.R. Role of laminin and basement membrane in the differentiation of human endothelial cells into capillary-like structures. J. Cell Biol. 107:1988;1589-1598.
14. Swerlick R.A., Garcia-Gonzales E., Kubota Y. Studies of the modulation of MHC antigen and cell adhesion molecule expression on human dermal microvascular endothelial cells. J. Invest. Dermatol. 97:1991;190-196.
15. Chajek T., Fainary M. Behçet's disease: report of 41 cases and a review of the medical literature. Medicine. 54:1975;179-196.
16. Slavin R.E., deGroot W.J. Pathology of the lung in Behçet's disease: case report and review of the literature. Am. J. Surg. Pathol. 5:1981;779-788.
17. Jorrizzo J.L., Solomon A.R., Zanolli M.D., Leshin B. Neutrophilic vascular reactions. J. Am. Acad. Dermatol. 19:1988;983-1005.
18. Carvalho D., Savage C.O.S., Black C.M., Pearson J.D. IgG antiendothelial cell antibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines. J. Clin. Invest. 97:1996;111-119.
19. Su B., Karin M. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8:1996;402-411.
20. Young P., McDonnell P., Dunnington D., Hand A., Laydon J., Lee J. Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level. Agents Actions. 39:1993;67-69.
21. Su B., Jacinto E., Hibi M., Kallunki T., Karin M., Ben-Neriah Y. JNK is involved in signal transduction during costimulation of T lymphocytes. Cell. 77:1994;727-736.
22. May M.J., Wheeler-Jones C.P., Pearson J.D. Effects of protein tyrosine kinase inhibitors on cytokine-induced adhesion molecules expression by human umbilical vein endothelial cells. Br. J. Pharmacol. 118:1996;1761-1771.
23. O'Rourke A.M., Shao H., Kaye J. A role for p21ras/MAP kinase in TCR-mediated activation of LFA-1. J. Immunol. 161:1998;5800-5803.