Safety and immunogenicity of pneumococcal conjugate vaccine in combination with diphtheria, tetanus toxoid, pertussis and Haemophilus influenzae type b conjugate vaccine

Pediatric Infectious Disease Journal

Volumn 21, Issue 10, 2002, Pages 940-946

  Obaro, Stephen K ^a   Enwere, Godwin C ^a   Deloria, Maria ^a   Jaffar, Shabbar ^a   Goldblatt, David ^a   Brainsby, Kate ^a   Hallander, Hans ^a   McInnes, Pamela ^a   Greenwood, Brian M ^a   McAdam, Keith P W J ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

African infant; Immunogenicity; Pneumococcal conjugate vaccine; Safety; TETRAMUNE

Indexed keywords

ANTIBODY; ANTIPYRETIC AGENT; DIPHTHERIA ANTIBODY; DIPHTHERIA PERTUSSIS TETANUS HAEMOPHILUS INFLUENZAE TYPE B VACCINE; PNEUMOCOCCUS VACCINE;

AFRICA; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CLINICAL TRIAL; CONJUGATE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRYING; DRUG EFFICACY; DRUG SAFETY; EDEMA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEEDING; FEVER; HUMAN; IMMUNOGENICITY; INFANCY; INFANT; INJECTION PAIN; MAJOR CLINICAL STUDY; NONHUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

CONFIDENCE INTERVALS; DEVELOPING COUNTRIES; DIPHTHERIA-TETANUS-PERTUSSIS VACCINE; FEMALE; GAMBIA; HAEMOPHILUS VACCINES; HUMANS; IMMUNITY; IMMUNIZATION PROGRAMS; IMMUNIZATION SCHEDULE; INFANT; MALE; POLYSACCHARIDES, BACTERIAL; PROBABILITY; REFERENCE VALUES; SAFETY; VACCINATION; VACCINES, COMBINED; VACCINES, CONJUGATE;

EID: 0036798869     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006454-200210000-00011     Document Type: Article

References (15)

1. 197 conjugate vaccine in infants and toddlers. Pediatr Infect Dis J 1999;18:757-63.
2. Usen S, Adegbola R, Mulholland K, et al. Epidemiology of invasive pneumococcal disease in the Western Region, The Gambia. Pediatr Infect Dis J 1998;1:23-8.
3. Leach A, Ceesay SJ, Banya WAS, Greenwood BM. Pilot trial of a pentavalent pneumococcal polysaccharide/protein conjugate vaccine in Gambian infants. Pediatr Infect Dis J 1996;15:333-9.
4. Obaro SK, Huo Z, Banya WAS, et al. A glycoprotein conjugate vaccine primes for antibody responses to a pneumococcal polysaccharide vaccine in Gambian children. Pediatr Infect Dis J 1997;16:1135-40.
5. Quataert SA, Kirch CS, Wiedl LJ, et al. Assignment of weight-based antibody units to a human antipneumococcal standard reference serum, Lot 89-S. Clin Diagn Lab Immunol 1995;2:590-7.
6. Manclarke CR, Meade BD, Bursyn DG. Serologic response to Bordetella pertussis. In: Rose NR, Friedman H, Fahey JL, eds. Manual of clinical laboratory immunology. 3rd ed. Washington, DC: American Society for Microbiology, 1986:388-94.
7. Paradiso PR, Hogerman DA, Madore DV, et al. Safety and immunogenicity of a combined diphtheria, tetanus, pertussis and Haemophilus influenzae type b vaccine in young infants Pediatrics 1993;93:827-33.
8. Phipps DC, West J, Eby R, Koster M, Madore DV, Quataert SA. An ELISA employing a Haemophilus influenzae type b oligosaccharide-human serum albumin conjugate correlates with radioantigen binding assay. J Immunol Methods 1990;135:121-8.
9. Farrington CP, Manning G. Test statistics and sample size formulae for comparative binomial trials with null hypothesis of non-zero risk difference or non-unity relative risk. Stat Med 9:1447-54.
10. 197 administered simultaneously but in a separate syringe with diphtheria, tetanus and pertussis vaccines in Gambian infants. Pediatr Infect Dis J 2000;19:463-9.
11. Choo S, Seymour L, Rhonwen M, et al. Immunogenicity and reactogenicity of a pneumococcal conjugate vaccine administered combined with a Haemophilus influenzae type b conjugate vaccine in United Kingdom infants. Pediatr Infect Dis J 2000;19:854-62.
12. Mbelle N, Huebner RE, Wasas AD, Kimura A, Chang I, Klugman KP. Immunogenicity and impact on nasopharyngeal carriage of a nonavalent pneumococcal conjugate vaccine. J Infect Dis 1999;180:1171-6.
13. Dagan R, Eskola J, Leclerc C, Leroy O. Reduced response to multiple vaccines sharing common protein epitopes that are administered simultaneously to infants. Infect Immun 1998;66:2093-8.
14. The Gambian Pneumococal Vaccine Trial Group. Preparations for a pneumococcal conjugate vaccine trial in the Gambia, West Africa [Abstract O 25]. In: Second International Symposium on Pneumococci and Pneumococcal Diseases, Sun City, South Africa, March 19 to 23, 2000.
15. Obaro SK, Enwere GC, Deloria M, et al. Safety and immunogenicity of a single injection of a 9-valent pneumococcal conjugate vaccine mixed with DTP-Hib (Tetramune®) in Gambian infants. [Abstract 46]. In: 40th Interscience Conference on Antimicrobials and Chemotherapy, Toronto, Canada, September 17 to 20, 2000. Washington, DC: American Society for Microbiology, 2000.