Inter-bouton variability of synaptic strength correlates with heterogeneity of presynaptic Ca2+ signals

Journal of Neurophysiology

Volumn 88, Issue 4, 2002, Pages 2172-2176

  Kirischuk, Sergei ^a   Grantyn, Rosemarie ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE; FLUORESCENCE; MEMBRANE ELECTROPHYSIOLOGY; NERVE CELL CULTURE; NEUROTRANSMISSION; NEWBORN; NONHUMAN; PATCH CLAMP; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; RAT;

EID: 0036798022     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.2002.88.4.2172     Document Type: Article

References (23)

1. Cox CL, Denk W, Tank DW, and Svoboda K. Action potentials reliably invade axonal arbors of rat neocortical neurons. Proc Natl Acad Sci USA 97: 9724-9728, 2000.
2. Dodge FA and Rahamimoff R. Co-operative action a calcium ions in transmitter release at the neuromuscular junction. J Physiol (Lond) 193: 419-432, 1967.
3. Helmchen F, Borst JG, and Sakmann B. Calcium dynamics associated with a single action potential in a CNS presynaptic terminal. Biophys J 72: 1458-1471, 1997.
4. Isaacson JS and Walmsley B. Counting quanta: direct measurements of transmitter release at a central synapse. Neuron 15: 875-884, 1995.
5. Katz B. The Release of Neural Transmission Substances. Liverpool: Liverpool Univ. Press, 1969.
6. Kerr R, Lev-Ram V, Baird G, Vincent P, Tsien RY, and Schafer WR. Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans. Neuron 26: 583-594, 2000.
7. Kirischuk S, Clements JD, and Grantyn R. Presynaptic and postsynaptic mechanisms underlie paired-pulse depression at single GABAergic boutons. J Physiol (Lond) In press.
8. Kirischuk S, Veselovsky N, and Grantyn R. Relationship between presynaptic calcium transients and postsynaptic currents at single gamma-aminobutyric acid (GABA)ergic boutons. Proc Natl Acad Sci USA 96: 7520-7525, 1999a.
9. Kirischuk S, Veselovsky N, and Grantyn R. Single-bouton-mediated synaptic transmission: postsynaptic conductance changes in their relationship with presynaptic calcium signals. Pflügers Arch 438: 716-724, 1999b.
10. Koester HJ and Sakmann B. Calcium dynamics associated with action potentials in single nerve terminals of pyramidal cells in layer 2/3 of the young rat neocortex. J Physiol (Lond) 529: 625-646, 2000.
11. Korn H and Faber DS. Regulation and significance of probabilistic release mechanisms at central synapses. in: Synaptic Function, edited by Edelman GM, Gall WE, and Cowan WM. New York: Wiley, 1987, p. 57-108.
12. Liang Y, Yuan LL, Johnston D, and Gray R. Calcium signaling at single mossy fiber presynaptic terminals in the rat hippocampus. J Neurophysiol 87: 1132-1137, 2002.
13. Llano I, Gonzalez J, Caputo C, Lai FA, Blayney LM, Tan YP, and Marty A. Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients. Nat Neurosci 3: 1256-1265, 2000.
14. 2+ signals in axons of basket cells from rat cerebellar slices. J Physiol (Lond) 502: 509-519, 1997.
15. 2+ imaging of CNS axons in culture indicates reliable coupling between single action potentials and distal functional release sites. Neuron 16: 783-795, 1996.
16. Meínrenken CJ, Borst JG, and Sakmann B. Calcium secretion coupling at calyx of held governed by nonuniform channel-vesicle topography. J Neurosci 22: 1648-1667, 2002.
17. Mozhayeva MG, Sara Y, Liu X, and Kavalali ET. Development of vesicle pools during maturation of hippocampal synapses. J Neurosci 22: 654-665, 2002.
18. 2+ microdomains: new tools for understanding their roles in neurotransmitter release. Neuron 20: 389-399, 1993.
19. Perouansky M and Grantyn R. Separation of quisqualate- and kainate-selective glutamate receptors in cultured neurons from the rat superior colliculus. J Neurosci 9: 70-80, 1989.
20. Regehr WG and Tank DW. The maintenance of LTP at hippocampal mossy fiber synapses is independent of sustained presynaptic calcium. Neuron 7: 451-459, 1991.
21. 2+ buffers in facilitating and depressing nerve terminals of pyramidal cells in layer 2/3 of the rat neocortex indicates a target cell-specific difference in presynaptic calcium dynamics. J Physiol (Lond) 531: 807-826, 2001.
22. Sahara Y and Takahashi T. Quantal components of the excitatory postsynaptic currents at a rat central auditory synapse. J Physiol (Lond) 536: 189-197, 2001.
23. 2+ channels mediate glutamatergic synaptic responses to activation of single Thy-l-immunolabeled rat retinal ganglion neurons. J Neurosci 15: 2240-2254, 1995.