Single-bouton-mediated synaptic transmission: Postsynaptic conductance changes in their relationship with presynaptic calcium signals

Pflugers Archiv European Journal of Physiology

Volumn 438, Issue 5, 1999, Pages 716-724

  Kirischuk, S ^a   Veselovsky, N ^a   Grantyn, R ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Ca2+ probes; EPSCs; Fluorescence vesicle markers; IPSCs; Low density neuronal culture; Presynaptic Ca2+ concentration; Single presynaptic terminal; Synaptic transmission

Indexed keywords

CALCIUM ION;

AMPLITUDE MODULATION; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; DENDRITE; DEPOLARIZATION; EMBRYO; EXCITATORY POSTSYNAPTIC POTENTIAL; INHIBITORY POSTSYNAPTIC POTENTIAL; ION CONDUCTANCE; NERVE CELL CULTURE; NERVE ENDING; NEUROTRANSMITTER RELEASE; NONHUMAN; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; SUPERIOR COLLICULUS; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION;

ANIMALS; CALCIUM; CELLS, CULTURED; DENDRITES; ELECTRIC CONDUCTIVITY; ELECTRIC STIMULATION; PRESYNAPTIC TERMINALS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 0032830178     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240051098     Document Type: Article

References (34)

1. 1. Walmsley B (1991) Central synaptic transmission: studies at the connection between primary afferent fibres and dorsal spinocerebellar tract (DSCT) neurones on Clarke's column of the spinal cord. Prog Neurobiol 36:391-423
2. 2. Redman S (1990) Quantal analysis of synaptic potentials in neurons of the central nervous system. Physiol Rev 70: 165-198
3. 3. Korn H, Faber DS (1987) Regulation and significance of probabilistic release mechanisms at central synapses. In: Edelman GM, Gall WE, Cowan WM (eds) Synaptic function. Wiley, New York, pp 57-108
4. 4. Redman S, Walmsley B (1983) The time course of synaptic potentials evoked in cat spinal motoneurones at identified group 1a synapses. J Physiol (Lond) 343:117-133
5. 5. Arancio O, Korn H, Gulyas A, Freund T, Miles R (1994) Excitatory synaptic connections onto rat hippocampal inhibitory cells may involve a single transmitter release site. J Physiol (Lond) 481:395-405
6. 6. Grantyn R, Shapovalov AI, Shiriaev BI (1984) Tracing of frog sensory-motor synapses by intracellular injection of horseradish peroxidase. J Physiol (Lond) 349:441-458
7. 7. Korn H, Mallet A, Triller A, Faber DS (1982) Transmission at a central inhibitory synapse. II. Quantal description of release, with a physical correlate for binomial n. J Neurophysiol 48: 679-707
8. 8. Lübke J, Markram H, Frotscher M, Sakmann B (1996) Frequency and dendritic distribution of autapses established by layer 5 pyramidal neurons in the developing rat neocortex: comparison with synaptic innervation of adjacent neurons of the same class. J Neurosci 16:3209-3218
9. 9. Buhl EH, Tamás G, Szìlágyi T, Stricker C, Paulsen O (1997) Effect, number and location of synapses made by single pyramidal cells onto aspiny interneurones of cat visual cortex. J Physiol (Lond) 500:689-713
10. 10. Liu G, Tsien RW (1995) Synaptic transmission at single visualized hippocampal boutons. Nature 375:404-408
11. 2+ imaging of CNS axons in culture indicates reliable coupling between single action potentials and distal functional release sites. Neuron 16:783-795
12. 12. Betz WJ, Bewick GS (1992) Optical analysis of synaptic vesicle recycling at the frog neuromuscular junction. Science 255:200-203
13. 13. Murthy VN, Sejnowski TJ, Stevens CF (1997) Heterogeneous release properties of visualized individual hippocampal synapses. Neuron 18:599-612
14. 14. Ryan TA, Reuter H, Wendland B, Schweizer FE, Tsien RW, Smith SJ (1993) The kinetics of synaptic vesicle recycling measured at single presynaptic boutons. Neuron 11:713-724
15. 15. Klingauf J, Kavalali ET, Tsien RW (1998) Kinetics and regulation of fast endocytosis at hippocampal synapses. Nature 394:581-585
16. 2+-channel blockers. Neuron 14:773-779
17. 17. Wu L, Betz WJ (1996) Nerve activity but not intracellular calcium determines the time course of endocytosis at the frog neuromuscular junction. Neuron 17:769-779
18. 18. Smith CB, Betz WJ (1996) Simultaneous independent measurement endocytosis and exocytosis. Nature 380:531-534
19. 19. Betz WJ, Angleson JK (1997) Now you see it, now you don't. Nature 388:423-424
20. 20. Katz B, Miledi R (1967) The release of acetylcholine from nerve endings by graded electric pulses. Proc R Soc Lond [Biol] 167:23-38
21. 21. Lavidis NA, Bennett MR (1993) Probabilistic secretion of quanta from successive sets of visualized varicosities along single sympathetic nerve terminals. J Auton Nerv Syst 43: 41-50
22. 22. Vautrin J, Schaffner AE, Barker JL (1993) Quantal and subquantal GABAergic transmissions in cultured rat hippocampal neurons. Hippocampus 3:93-102
23. 23. Kirischuk S, Veselovsky N, Grantyn R (1999) Relationship between presynaptic calcium transients and postsynaptic currents at single γ-aminobutyric acid (GABA)ergic boutons. Proc Natl Acad Sci USA (in press)
24. 24. Grantyn R, Veselovsky NS (1998) Release capacity of single inhibitory synapses in collicular cultures. In: Faber DS, Korn H, Redman SJ, Thompson SM, Altman JS (eds) Central synapses: quantal mechanisms and plasticity. HFSP, Strasbourg, pp 146-53
25. 25. Perouansky M, Grantyn R (1989) Separation of quisqualate-and kainate-selective glutamate-receptors in cultured neurons from the rat superior colliculus. J Neurosci 9:70-80
26. 26. Kraszewski K, Grantyn R (1992) Development of GABAergic connections in vitro: Increasing efficacy of synaptic transmission is not accompanied by changes in miniature currents. J Neurobiol 23:766-781
27. 27. Kraszewski K, Grantyn R (1992) Unitary, quantal and miniature GABA-activated synaptic chloride currents in cultured neurons from the rat superior colliculus. Neuroscience 47: 555-570
28. 28. Kraszewski K, Daniell L, Mundigl O, De Camilli P (1996) Mobility of synaptic vesicles in nerve endings monitored by recovery from photobleaching of synaptic vesicle-associated fluorescence. J Neurosci 16:5905-5913
29. 29. Ryan TA, Smith SJ, Reuter H (1996) The timing of synaptic vesicle endocytosis. Proc Natl Acad Sci USA 93:5567-5571
30. 30. Vogt K, Lüscher HR, Streit J (1995) Analysis of synaptic transmission at single identified boutons on rat spinal neurons in culture. Pflügers Arch 430:1022-1028
31. 31. Bekkers JM, Stevens CF (1995) Quantal analysis of EPSCs recorded from small numbers of synapses in hippocampal cultures. J Neurophysiol 73:1145-1156
32. 32. Rosenmund C, Stevens CF (1996) Definition of the readily releasable pool of vesicles at hippocampal synapses. Neuron 16:1197-1207
33. 33. Liu G, Tsien RW (1995) Properties of synaptic transmission at single hippocampal synaptic boutons. Neuropharmacology 34:1407-1421
34. 34. Ramaswami M, Krishnan KS, Kelly RB (1994) Intermediates in synaptic vesicle recycling revealed by optical imaging of Drosophila neuromuscular junctions. Neuron 13:363-375