Haloperidol inhibits (-) bicuculline-induced seizures and bicuculline potentiates haloperidol-induced catalepsy in mice.

Indian Journal of Pharmacology

Volumn 31, Issue 6, 1999, Pages 434-436

  Somani, Rahul S ^a   Kasture, Veena S ^a   Kasture, Sanjay B ^a  

^a Department of Pharmacology   (India)

Author keywords

Bicuculline; Catalepsy; Haloperidol; Seizures

Indexed keywords

4 AMINOBUTYRIC ACID; BICUCULLINE; HALOPERIDOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALEPSY; CLONIC SEIZURE; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; DOSE RESPONSE; DRUG ANTAGONISM; DRUG INHIBITION; DRUG POTENTIATION; MALE; MOUSE; MYOCLONUS SEIZURE; NONHUMAN; SEIZURE;

EID: 0033376605     PISSN: 02537613     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Sanberg PR. Haloperidol-induced catalepsy is mediated by postsynaptic dopamine receptors. Nature 1980;284:472-3.
2. Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trends Neurosci 1989;12:366-75.
3. Mink JW, Thatch WT. Basal ganglia intrinsic circuits and their role in behaviour. Curr Opinion in Neurobiol 1993;3: 950-7.
4. Wichman T, DeLong MR. Pathophysiolology of Parkinsonian motor abnormalities. Adv in Neurol 1993;60:53-51.
5. Bevan MD, Booth PAD, Eaton SA, Bolam JP. Selective innervation of neostriatal interneurons by a subclass of neuron in the globus pallidus of the rat. J Neurosci 1998;18: 9438-52.
6. Floran B, Floran L, Sierra A, Aceves J. D2 receptor mediated inhibition of GABA release by endogenous dopamine in rat globus pallidus. Neurosci Lett 1997;237:1-4.
7. Ferre S, GuixT, Prat G, Jane F, Casas M. Is experimental catalepsy properly measured ? Pharmac Biochem Behav 1990;35: 753-7.
8. Palmer GC, Stagnitto ML, Garske GE, et al. Anticonvulsant efficacy/safety properties of 2-amino-N-(1,2-diphenylethyl) acetamide hydrochloride. J Pharmacol Exp Ther 1995;273:1023-31.
9. Ossowska K, Karcz M, Wardas J, Wolfarth S. Striatal and nucleus accumbens D1/D2 dopamine receptors in neuroleptic catalepsy. Eur J Pharmac 1990;182:327-34.
10. Barar FSK. In : Essentials of Pharmacotherapeutics. 2nd edition, New Delhi: S.Chand & Co., 1994:282.
11. A receptor: an in vivo electrochemical study. Brain Res 1998;798:156-65.
12. Stanford IM, Lacey MG. Regulation of potassium conductance in rat midbrain dopamine neurons by intracellular adenosine triphosphate (ATP) and the sulfonylureas tolbutamide and glibenclamide. J Neurosci 1995;15: 4651-7.