Brn-3a, a neuronal transcription factor of the POU gene family: Indications for its involvement in cancer and angiogenesis

Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology

Volumn 22, Issue 2, 2002, Pages 123-127

  Chiarugi, Vincenzo ^a   Del Rosso, Mario ^a   Magnelli, Lucia ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Bcl 2; Brn 3a; P53; VEGF

Indexed keywords

PROTEIN BCL 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR POU4F1; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; CANCER; CARCINOGENESIS; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; MULTIGENE FAMILY; NERVE CELL; ONCOGENE; PROMOTER REGION; REVIEW; TRANSACTIVATION;

ALTERNATIVE SPLICING; DNA-BINDING PROTEINS; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; ONCOGENES; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSCRIPTION FACTOR BRN-3; TRANSCRIPTION FACTOR BRN-3A; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0036796923     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/MB:22:2:123     Document Type: Review

References (30)

1. Agarwal, M.L., Taylor, W.R., Chernov, M.V., Chernova, O.B., and Stark, G.R. (1998) The p53 network. J. Biol. Chem. 273,1-4.
2. Levine, A.J. (1997) p53, the cellular gatekeeper for growth and division. Cell 88, 323-331.
3. Slee, E.A., Harte, M.T., Kluck, R.M., et al. (1999) Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J. Cell Biol. 144, 281-292.
4. Cecconi, F., Alvarez-Bolado, G., Meyer, B.I., Roth, K.A., and Gruss, P. (1998) Apafl (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94, 727-737.
5. Adams, J.M. and Cory, S. (1998) The Bcl-2 protein family: arbiters of cell survival. Science 281,1322-1326.
6. Korsmeyer, S.J. (1992) Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 80, 879-886.
7. Tsujimoto, Y. (1998) Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes Cells 3, 697-707
8. Reed, J.C. (1994) Bcl-2 and the regulation of programmed cell death. J. Cell Biol. 124, 1-6.
9. Lee, W.Y., Jin, Y.T., and Tzeng, C.C. Reciprocal expression of Bcl-2 and p53 in breast ductal carcinoma. (1996) Anticancer Res. 16, 3007-3012.
10. Hoehner, J.C., Gestblom, C., Olsen, L., and Pahlman, S. (1997) Spatial association of apoptosis-related gene expression and cellular death in clinical neuroblastoma. Br. J. Cancer 75,1185-1186.
11. Miyashita, T., Krajewski, S., Krajewska, M., et al. (1994) Tumor suppressor p53 is a regulator of Bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9, 1799-1805.
12. Miyashita, T., Harigai, M., Hanada, M., and Reed, J.C. (1994b) Identification of a p53-dependent negative response element in the Bcl-2 gene. Cancer Res. 54, 3131-3135.
13. Latchman, D.S. (1998) The Brn-3a transcription factor. Int. J. Biochem. Cell Biol. 30, 1153-1157.
14. Budhram-Mahadeo, V., Morris, P..J, Smith, M.D., Midgley, C.A., Boxer, L.M., and Latchman D.S. (1999) p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. J. Biol. Chem. 274, 15237-15244.
15. Smith, M.D., Ensor, E.A., Coffin, R.S., Boxer, L.M., and Latchman, D.S. (1998) Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factor. J. Biol. Chem. 273, 16715-16722.
16. Ndisang, D., Budhram-Mahadeo, V., and Latchman, D.S. (1999) The Brn-3a transcription factor plays a critical role in regulating human papilloma virus gene expression and determining the growth characteristics of cervical cancer cells. J. Biol. Chem. 274, 28521-28527.
17. Theil, T., McLean-Hunter, S., Zornig, M., and Moroy, T. (1993) Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Nucleic Acids. Res. 21, 5921-5929
18. Leblond-Francillard, M., Picon, A., Bertagna, X., and de Keyzer, Y. (1997) High expression of the POU factor Brn3a in aggressive neuroendocrine tumors. J. Clin. Endocrinol. Metab. 82, 89-94.
19. Xie, B., Tam, N.N., Tsao, S.W., and Wong, Y.C. (1999) Co-expression of vascular endothelial growth factor (VEGF) and its receptors (flk-1 and flt-1) in hormone-induced mammary cancer in the Noble rat. Br. J. Cancer 81, 1335-1343.
20. Lane, D.P. (1994) The regulation of p53 function: Steiner Award Lecture. Int. J. Cancer 57, 623-627.
21. Folkman, J. (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1, 27-31.
22. Korpelainen, E.I., and Alitalo, K. (1998) Signaling angiogenesis and lymphangiogenesis. Curr. Opin. Cell Biol. 10, 159-164.
23. Biroccio, A., Candiloro, A., Mottolese, M., et al. (2000) Bcl-2 overexpression and hypoxia synergistically act to modulate vascular endothelial growth factor expression and in vivo angiogenesis in a breast carcinoma line. FASEB J. 14, 652-660.
24. Gerber, H.P., Dixit, V., and Ferrara, N. (1998) Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J. Biol. Chem. 273, 13313-13316.
25. Nor, J.E., Christensen, J., Mooney, D.J., and Polverini, P.J. (1999) Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am. J. Pathol. 154, 375-384.
26. Gay, R.D., Dawson, S.J., Murphy, W.J., Russell, S.W., and Latchman, D.S. (1998) Activation of the iNOS gene promoter by Brn-3 POU family transcription factors is dependent upon the octamer motif in the promoter. Biochim. Biophys. Acta 1443, 315-322.
27. Chiarugi, V., Magnelli, L., and Gallo, O. (1998) Cox-2, iNOS and p53 as play-makers of tumor angiogenesis. Int. J. Mol. Med. 2, 715-719.
28. Pal, S., Datta, K., and Mukhopadhyay, D. (2001) Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma. Cancer Res. 61, 6952-6957.
29. Holash, J., Wiegand, S.J., and Yancopoulos, G.D. (1999) New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 18, 5356-5362.
30. Parenti, A., Morbidelli, L., Cui, X.L., et al. (1998) Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium. J. Biol. Chem. 273, 4220-4226.