The surprises of mammalian molecular cell biology

Nature Medicine

Volumn 8, Issue 10, 2002, Pages 1068-1071

  Darnell Jr , James E ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL MARKER; COMPLEMENTARY DNA; HETEROGENEOUS NUCLEAR RNA; INTERFERON; MESSENGER RNA; RNA; STAT PROTEIN; VIRUS DNA; VIRUS PROTEIN; VIRUS RNA; DNA BINDING PROTEIN; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ADENOVIRUS; CYTOLOGY; DNA RNA HYBRIDIZATION; GENE CONTROL; GENETICS; HELA CELL; HUMAN; MAMMAL CELL; MEDICAL RESEARCH; MOLECULAR BIOLOGY; NONHUMAN; NOTE; ONCOLOGY; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; RNA ANALYSIS; VIROLOGY; ANIMAL; ART; ARTICLE; AWARDS AND PRIZES; CELL FUNCTION; HISTORY; LITERATURE; METABOLISM; NON PROFIT ORGANIZATION; UNITED STATES;

ANIMALS; AUTOBIOGRAPHY; AWARDS AND PRIZES; CELL PHYSIOLOGY; DNA-BINDING PROTEINS; FOUNDATIONS; HISTORY, 20TH CENTURY; HUMANS; INTERFERONS; MOLECULAR BIOLOGY; PORTRAITS; RNA, HETEROGENEOUS NUCLEAR; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; UNITED STATES;

EID: 0036796084     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm773     Document Type: Note

References (42)

1. Glaser, R.J., Thomas, W.A., Morse, S.I. & Darnell, J.E Jr. The incidence and pathogenesis of myocarditis in rabbits after Group A streptococccal pharyngeal infections. J. Exp. Med. 103, 173 (1956).
2. Darnell, J.E. Jr. Adsorption and maturation of poliovirus in singly and multiply infected HeLa cells. J. Exp. Med. 107, 633-641 (1958).
3. Darnell, J.E. Jr. & Levintow, L. Poliovirus protein: Source of amino acids and time course of synthesis. J. Bio. Chem. 235, 70-73 (1960).
4. Darnell, J.E. Jr., Levintow, L., Thoren, M. & Hooper, L. The time course of synthesis of poliovirus RNA. Virology 13, 271-279 (1960).
5. Jacob, F. & Monod, J. Genetic regulatory mechanisms in the synthesis of proteins. J. Mol. Biol. 3, 318-356 (1961).
6. Scherrer, K. & Darnell, J.E. Jr. Sedimentation characteristics of rapidly labeled RNA from HeLa cells. Biochem. Biophys. Res. Comm. 7, 486-490 (1962).
7. Soeiro, R., Birnboim, H.C. & Darnell, J.E. Jr. Rapidly labeled HeLa cell nucler RNA. II. Base composition and cellular localization of a heterogenous RNA fraction. J. Mol. Biol. 19, 362-372 (1966).
8. Darnell, J.E. Jr. Ribonucleic acids from animal cells. Bacteriolog. Rev. 32, 262-290 (1968).
9. Penman, S., Scherrer, K., Becker, Y. & Darnell, J.E. Jr. Polyribosomes in normal and poliovirus infected HeLa cells and their relationship to messenger RNA. Proc. Natl. Acad. Sci. USA 49, 654-662 (1963).
10. Lindberg, U. & Darnell, J.E. Jr. SV40 specific RNA in the nucleus and polyribosmes of transformed cells. Proc. Natl. Acad. Sci. USA 65, 1089-1096 (1970).
11. Darnell, J.E. Jr., Wall, R. & Tushinski, R.J. An adenylic acid rich sequence in mRNA of HeLa cells and its possible relationship to reiterated sites in DNA. Proc. Natl. Acad. Sci. USA 68, 1321-1325 (1971).
12. Edmonds, M., Vaughan, M.H. & Nakazato, H. Polyadenylic acid sequences in the heterogenous nuclear RNA and rapidly labeled polyribosomal RNA of HeLa cells: Possible evidence for a precursor relationship. Proc. Natl. Acad. Sci. USA 68, 1336-1340 (1971).
13. Lee, S.Y., Mendecki, J. & Brawerman, G. A polynucleotide segment rich in adenylic acid in rapidly labeled polyribosomal RNA of mouse sarcoma 180 ascites cells. Proc. Natl. Acad. Sci. USA 68, 1331-1335 (1971).
14. Kates, J. Transcription of vaccinia virus genome and the occurrence of polyriboadendylic acid sequences in messenger RNA. Cold Spring Harbor Symp. Quant. Biol. XXXV, 743-752 (1970 published February, 1971)).
15. Darnell, J.E. Jr., Philipson, L., Wall, R. & Adesnik, M. Polyadenylic acid sequences: Role in conversion of nuclear RNA into messenger RNA. Science 174, 507-510 (1971).
16. Philipson, L., Wall, R., Glickman, G. & Darnell, J.E. Jr. Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication. Proc. Natl. Acad. Sci. USA 68, 2806-2809 (1971).
17. Weber, J., Jelinek, W. & Darnell, J.E. Jr. The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: Mapping of nascent RNA molecules labeled in isolated nuclei. Cell 10, 611-616 (1977).
18. Goldberg, S., Weber, J. & Darnell, J.E. Jr. The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: Mapping by effects of ultraviolet irradiation. Cell 10, 617-621 (1977).
19. Perry, R.P. & Kelley, D.E. Existence of methylated messenger RNA in mouse L cells. Cell 1, 37-42 (1974).
20. Shatkin, A.J. Capping of eucaryotic mRNAs. Cell 9 645-653 (1976).
21. Salditt-Georgieff, M. et al. Methyl labeling of HeLa cell HnRNA: A comparison with mRNA. Cell 7, 227-237 (1976).
22. Berget, S.M., Moore, C. & Sharp, P.A. Spliced segments at the 5′ terminus of adenovirus 2 late mRNA. Proc. Natl. Acad. Sci. USA 74, 3171-3175 (1977).
23. Chow, L.T., Gelinas, R., Broker, T.R. & Roberts, R.J. An amazing sequence arrangement at the 5′ ends of adenovirus mesenger RNA. Cell 12, 1-8 (1977).
24. Derman, E., et al. Transcriptional control in the production of liver-specific mRNAs. Cell 23, 731-739 (1981).
25. Powell, D.J., Friedman, J., Oulette, A.J., Krauter, K.S. & Darnell, J.E. Jr. Transcriptional and posttranscriptional control of specific messenger RNAs in adult and embryonic liver. J. Mol. Biol. 179, 21-35 (1984).
26. Clayton, D.F., Harrelson, A.L. & Darnell, J.E. Jr. Dependence of liver-specific transcription on tissue organization. Mol. Cell. Biol. 5, 2623-2632 (1985).
27. Knight, E. Jr. & Korant, B.D. Fibroblast interferon induces synthesis of four proteins in human fibroblast cells. Proc. Natl. Acad. Sci. USA 76, 1824-1827 (1979).
28. Larner, A.C. et al, Transcriptional induction of two genes in human cells by b interferon. Proc. Natl. Acad. Sci. USA 81, 6733-6737 (1984).
29. Levy, D. & Darnell, J.E. Jr. Interferon-dependent transcriptional activation: Signal transduction without second messenger involvement? New Biol. 2, 923-928 (1990).
30. Darnell, J.E. Jr., Kerr, I.M. & Stark, G.M. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421 (1994).
31. Schindler, C., Fu, X.-Y., Improta, T., Aebersold, R. & Darnell, J.E. Jr. Proteins of transcription factor ISGF-3: One gene encodes the 91 and 84 kDA ISGF-3 proteins that are activated by inteferon-α. Proc. Natl. Acad. Sci. USA 89, 7836-7839 (1992).
32. Shuai, K., Stark, G.R., Kerr, I.M. & Darnell, J.E. Jr. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ. Science 261, 1744-1746 (1993).
33. Zhong, Z., Wen, Z. & Darnell, J.E. Jr. tat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264, 95-98 (1994).
34. Zhong, Z., Wen, Z. & Darnell, J.E. Jr. Stat3 and Stat4: Members of the family of signal transducers and activators of transcription. Proc. Natl. Acad. Sci. USA 91, 4806-4810 (1994).
35. Levy, D. & Darnell, J.E. Jr. STATs: Transcriptional control and biologic impact. Nature Rev. Mol. Cell Biol. 3, 651-662 (2002).
36. Garcia, R. & Jove, R. Activation of STAT transcription factors in oncogenic tyrosine kinase signaling. J. Biomed. Sci. 5, 79-85 (1998).
37. Bowman, T., Garcia, R., Turkson, J. & Jove, R. STATs in oncogenesis. Oncogene 19, 2474-2488 (2000).
38. Bromberg, J.F. et al. Stat3 as an oncogene. Cell 98, 295-303 (1999).
39. Shen, Y., Devgan, G., Darnell, J.E. Jr. & Bromberg, J.F. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proc. Natl. Acad. Sci. USA 98, 1543-1548 (2001).
40. Darnell, J.E. Jr. Transcription factors as targets for cancer therapy. Nature Rev. Cancer (in the press).
41. Warner, J., Soeiro, R., Birnboim, H.C., Girard, M. & Darnell, J.E. Jr. Rapidly labeled HeLa cell nuclear RNA. I. Identification by zone sedimentation of a heterogeneous fraction separate from ribosomal precursor RNA. J. Mol. Biol. 19, 349-361 (1966).
42. Scherrer, K., Latham, H. & Darnell, J.E. Jr. Demonstration of an unstable RNA and of a precursor to ribosomal RNA in HeLa cells. Proc. Natl. Acad. Sci. USA 49, 240-248 (1963).