Effects of carprofen and dexamethasone on canine chondrocytes in a three-dimensional culture model of osteoarthritis

American Journal of Veterinary Research

Volumn 63, Issue 10, 2002, Pages 1363-1369

  Dvorak, Laura D ^a   Cook, James L ^a   Kreeger, John M ^a   Kuroki, Keiichi ^a   Tomlinson, James L ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGAROSE; CARPROFEN; COLLAGEN TYPE 2; COLLAGENASE 3; DEXAMETHASONE SODIUM PHOSPHATE; GLYCOSAMINOGLYCAN POLYSULFATE; PROSTAGLANDIN E2; RECOMBINANT INTERLEUKIN 1BETA; STROMELYSIN;

ANIMAL CELL; ARTICLE; ARTICULAR CARTILAGE; CARBOHYDRATE ANALYSIS; CARTILAGE CELL; CELL CULTURE; CELL ISOLATION; CELL PROTECTION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DISEASE MODEL; DOG; DRUG EFFECT; ENZYME ASSAY; EXTRACELLULAR MATRIX; HUMERUS HEAD; LIQUID CULTURE; MONOLAYER CULTURE; NONHUMAN; OSTEOARTHRITIS; QUANTITATIVE ANALYSIS; SPECTROPHOTOMETRY;

ANIMALIA; CANIS FAMILIARIS;

EID: 0036793331     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2002.63.1363     Document Type: Article

References (44)

1. Johnston SA. Osteoarthritis. Joint anatomy, physiology, and pathobiology. Vet Clin North Am Small Anim Pract 1997;27:699-723.
2. Herman JH, Sowder WG, Hess EV. NSAID induction of interleukin 1/catabolin inhibitor by osteoarthritic synovial tissue. J Rheumatol 1991;18(suppl 27):124-126.
3. Dingle JT. Cartilage maintenance in osteoarthritis: interaction on cytokines, NSAID and prostaglandins in articular cartilage damage and repair. J Rheumatol 1991;28(suppl):30-37.
4. Hugenberg ST, Brandt KD, Cole CA. Effect of sodium salicylate, aspirin, and ibuprofen on enzymes required by the chondrocyte for synthesis of chondroitin sulfate. J Rheumatol 1993;20:2128-2133.
5. Bassleer CT, Henrotin YE, Reginster JL, et al. Effects of tiaprofenic acid and acetylsalicylic acid on human articular chondrocytes in 3-dimensional culture. J Rheumatol 1992;19:1433-1438.
6. Lane-Smith R, Kajiyama G, Lane NE. Nonsteroidal antiinflammatory drugs: effects on normal and interleukin 1 treated human articular chondrocyte metabolism in vitro. J Rheumatol 1995; 22:1130-1137.
7. Lane NE, Williams RJ, Schurman DJ, et al. Inhibition of interleukin 1 induced chondrocyte protease activity by a corticosteroid and a nonsteroidal antiinflammatory drug. J Rheumatol 1992;19:135-139.
8. Trotter GW, McIlwraith CW, Yovich JV, et al. Effects of intraarticular administration of methylprednisolone acetate on normal equine articular cartilage. Am J Vet Res 1991;52:83-87.
9. Vasseur PB, Johnson AL, Budsberg SC, et al. Randomized, controlled trial of the efficacy of carprofen, a nonsteroidal antiinflammatory drug, in the treatment of osteoarthritis in dogs. J Am Vet Med Assoc 1995;206:807-811.
10. O'Brien WM, Bagby GF. Carprofen: a new nonsteroidal antiinflammatory drug; pharmacology, clinical efficacy and adverse effects. Pharmacotherapy 1987;7:16-24.
11. Tursi A, Loria MR, Specchia G, et al. In vitro studies of antiinflammatory activity of carprofen. Eur J Rheumatol Inflamm 1982;5: 488-491.
12. Fox SM, Johnston SA. Use of carprofen for the treatment of pain and inflammation in dogs. J Am Vet Med Assoc 1997;210:1493-1498.
13. Benton HP, Vasseur PB, Broderick-Villa GA, et al. Effect of carprofen on sulfated glycosaminoglycan metabolism, protein synthesis, and prostaglandin release by cultured osteoarthritic canine chondrocytes. Am J Vet Res 1997;58:286-292.
14. 2 from equine chondrocytes and cartilage explants. Am J Vet Res 1999;60:98-104.
15. Johnston SA, Budsberg SC. Nonsteroidal anti-inflammatory drugs and corticosteroids for the management of canine osteoarthritis. Vet Clin North Am Small Anim Pract 1997;27:841-862.
16. Simmons DJ, Kunin AS. Autoradiographic and biochemical investigations of the effect of cortisone on the bones of the rat. Clin Orthop 1967;55:201-215.
17. Kunin AS, Meyer WL. The effect of cortisone on the intermediary metabolism of epiphyseal cartilage from rats. Arch Biochem Biophys 1969;129:421-430.
18. Hainque B, Dominice J, Jaffray P, et al. Effects of dexamethasone on the growth of cultured rabbit articular chondrocytes: relation with the nuclear glucocorticoid-receptor complex. Ann Rheum Dis 1987;46:146-152.
19. Oikarinen AI, Vuorio EI, Zaragoza EJ, et al. Modulation of collagen metabolism by glucocorticoids: receptor-mediated effects of dexamethasone on collagen biosynthesis in chick embryo fibroblasts and chondrocytes. Biochem Pharmacol 1988;37:1451-1462.
20. Srinivas GR, Chichester CO, Barrach HJ, et al. Effects of certain antiarthritic agents on the synthesis of type II collagen and glycosaminoglycans in rat chondrosarcoma cultures. Agents Actions 1994;41:193-199.
21. Pelletier JP, Martel-Pelletier J. Protective effects of corticosteroids on cartilage lesions and osteophyte formation in the Pond-Nuki dog model of osteoarthritis. Arthritis Rheum 1989;32:181-193.
22. Pelletier JP, DiBattista JA, Raynauld JP, et al. The in vivo effects of intraarticular corticosteroid injections on cartilage lesions, stromelysin, interleukin-1, and oncogene protein synthesis in experimental osteoarthritis. Lab Invest 1995;72:578-586.
23. Thompson AY, Peiz KA, Seyedin SM. Chondrogenesis in agarose culture: a model for chondrogenic induction, proliferation, and differentiation. Exp Cell Res 1985;157:483-494.
24. Buschmann MD, Gluzband YA, Grodzinsky AJ, et al. Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix. J Orthop Res 1992;10:745-758.
25. Cook JL, Kreegar JM, Payne JT, et al. Three-dimensional culture of canine articular chondrocytes on multiple transplantable substrates. Am J Vet Res 1997;58:419-424.
26. Cook JL, Anderson CC, Kreegar JM, et al. Effects of human recombinant IL-1β on articular chondrocytes in three-dimensional culture. Am J Vet Res 2000;61:766-770.
27. Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 1986;883:173-177.
28. Benya PD, Shaffer JD. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 1982;30:215-224.
29. Brittberg M, Lindahl A, Nilsson A, et al. Cellular aspects on treatment of cartilage injuries. Agents Actions Suppl 1993;39:237-240.
30. Cook JL, Kreegar JM, Payne JT, et al. Effects of EGF, FGF, and PDGF on canine chondrocytes in three-dimensional culture. Vet Comp Orthop Traumatol 1997;10:210-213.
31. Pujol JP, Loyau G. Interleukin-1 and osteoarthritis. Life Sci 1987;41:1187-1198.
32. Tiku K, Thakker-Varia S, Ramanchandrua A, et al. Articular chondrocytes secrete IL-1, express membrane IL-1, and have IL-1 inhibitory activity. Cell Immunol 1992;140:1-20.
33. Goldring MB. Degradation of articular cartilage in culture: regulatory factors. In: Woessner JF, Howell DS, eds. Joint cartilage degradation: basic and clinical aspects. New York: Marcel Dekker Inc, 1993;281-345.
34. Goldring MB, Birhead J, Sandell LJ, et al. Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes. J Clin Invest 1988;82:2026-2037.
35. Schneider TA, Budsberg SC. Plasma and synovial concentrations of carprofen in dogs with chronic osteoarthritis. Vet Comp Orthop Traumatol 2001;14:19-24.
36. Pelletier JP, McCollum R, DiBattista J, et al. Regulation of human normal and osteoarthritic chondrocyte interleukin-1 receptor by antirheumatic drugs. Arthritis Rheum 1993;36:1517-1527.
37. Caron JP, Tardif G, Martel-Pelletier J, et al. Modulation of matrix metalloprotease 13 (collagenase 3) gene expression in equine chondrocytes by interleukin 1 and corticosteroids. Am J Vet Res 1996; 57:1631-1634.
38. Martel-Pelletier J, McCollum R, Fujimoto N, et al. Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis. Lab Invest 1994;70:807-815.
39. Okada Y, Shinmei M, Tanaka O, et al. Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium. Lab Invest 1992;66:680-690.
40. Shinmei M, Kikuchi T, Masuda K, et al. Effects of interleukin-1 and anti-inflammatory drugs on the degradation of human articular cartilage. Drugs 1988;35(suppl 1):33-41.
41. Quintavalla JC, Berg RA, Beavis AJ, et al. Differential induction of stromelysin mRNA by bovine articular chondrocytes treated with interferon-γ and interleukin-1α. J Cell Physiol 1993;154:113-121.
42. Kolibas LM, Goldberg RL. Effect of cytokines and antiarthritic drugs on glycosaminoglycan synthesis by bovine articular chondrocytes. Agents Actions 1989;27:245-249.
43. Dearden LC, Mosier HD, Espinosa T. Cortisone induced alterations of costal cartilage in single and in parabiosed rats. Cell Tissue Res 1978;189:67-89.
44. Bonucci E, Dearden LC, Mosier HD. Effects of glucocorticoid treatment on the ultrastructure of cartilage and bone. In: Avioli LV, Gennari C, Imbimbo B, eds. Glucocorticoid effects and their biological consequences. New York: Plenum Press Inc, 1984;269-278.