Acute pulmonary embolism: Don't ignore the platelet

Circulation

Volumn 106, Issue 14, 2002, Pages 1748-1749

  Sobieszczyk, Piotr ^a   Fishbein, Michael C ^b   Goldhaber, Samuel Z ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UCLA MEDICAL CENTER   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Editorials; Embolism; Platelets; Pulmonary heart disease; Thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; DIPYRIDAMOLE; ENOXAPARIN; HEPARIN; HYDROXYCHLOROQUINE; INDOMETACIN; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE INHIBITOR; SEROTONIN; THROMBOXANE A2; TICLOPIDINE;

BLEEDING; BLOOD CLOTTING; CAUSE OF DEATH; CLINICAL TRIAL; CORONARY ARTERY ATHEROSCLEROSIS; DRUG EFFICACY; DRUG SAFETY; EDITORIAL; HUMAN; LUNG BLOOD FLOW; LUNG EMBOLISM; PRIORITY JOURNAL; SEROTONIN RELEASE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTOPOIESIS; THROMBOEMBOLISM; TREATMENT OUTCOME; VEIN THROMBOSIS;

ACUTE DISEASE; ANIMALS; ANTICOAGULANTS; ASPIRIN; BLOOD PLATELETS; CLINICAL TRIALS; DISEASE MODELS, ANIMAL; FIBRINOLYTIC AGENTS; HUMANS; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PULMONARY EMBOLISM; RECURRENCE; TICLOPIDINE;

EID: 0036789389     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000035277.48823.01     Document Type: Editorial

References (27)

1. Silverstein MD, Heit JA, Mohr DN, et al. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med. 1998;158:585-593.
2. Goldhaber SZ. Pulmonary embolism. N Engl J Med. 1998;339:93-104.
3. Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). Lancet. 1999;353:1386-1389.
4. Cotran RS, Kumar V, Robins SL, eds. Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, Pa: W.B. Saunders Co; 1994.
5. Grossman ZD, Wistow BW, McAfee JG, et al. Platelets labeled with oxine complexes of Tc-99 m and In-111: part 2. Localization of experimentally induced vascular lesions. J Nucl Med. 1978;19:488-491.
6. Ezekowitz MD, Pope CF, Sostman HD, et al. Indium-111 platelet scintigraphy for the diagnosis of acute venous thrombosis. Circulation. 1986;73:668-674.
7. Thomas DP, Tanabe G, Khan M, et al. Humoral factors mediated by platelets in experimental pulmonary embolism. In: Sasahara AA, Stein M, eds. Pulmonary Embolic Disease. New York, NY: Grune and Stratton: 1965:59-64.
8. Nielsen HK. Pathophysiology of venous thromboembolism. Semin Thromb Hemost. 1991;17(suppl 3):250-253.
9. Garcia-Szabo R, Johnson A, Malik AB. Thromboxane increases pulmonary vascular resistance and transvascular fluid and protein exchange after pulmonary microembolism. Prostaglandins. 1988;35:707-721.
10. Klotz TA, Cohn LS, Zipser RD. Urinary excretion of thromboxane B2 in patients with venous thromboembolic disease. Chest. 1984;85:329-335.
11. Lualdi JC, Goldhaber SZ. Right ventricular dysfunction after acute pulmonary embolism: pathophysiologic factors, detection, and therapeutic implications. Am Heart J. 1995;130:1276-1282.
12. Todd MH, Forrest JB, Cragg DB. The effects of aspirin and methysergide on responses to clot-induced pulmonary embolism. Am Heart J. 1983;105:769-776.
13. Todd MH, Forrest JB, Cragg DB. The effects of aspirin and methysergide, singly and in combination, on systemic haemodynamic responses to pulmonary embolism. Can Anaesth Soc J. 1981;28:373-380.
14. Utsunomiya T, Krausz MM, Levine L, et al. Thromboxane mediation of cardiopulmonary effects of embolism. J Clin Invest. 1982;70:361-368.
15. Delcroix M, Melot C, Lejeune P, et al. Cyclooxygenase inhibition aggravates pulmonary hypertension and deteriorates gas exchange in canine pulmonary embolism. Am Rev Respir Dis. 1992;145:806-810.
16. Collaborative overview of randomised trials of antiplatelet therapy - III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. Antiplatelet Trialists' Collaboration. BMJ. 1994;308:235-246.
17. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002;324:71-86.
18. Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial. Lancet. 2000;355:1295-1302.
19. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet. 1996; 348:1329-1339.
20. Yusuf S, Zhao F, Mehta SR, et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345:494-502.
21. Lincoff AM, Califf RM, Topol EJ. Platelet glycoprotein IIb/IIIa receptor blockade in coronary artery disease. J Am Coll Cardiol. 2000;35:1103-1115.
22. Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA 2002 guidelines update for the management of patients with unstable angina and non ST-segment elevation myocardial infarction: a report of the ACC/AHA Task Force on Practice Guidelines (Committee on Management of Patients with Unstable Angina). 2002. Available at: http:/www.acc.org/clinical/guidelines/ unstable/unstable.pdf.
23. Efficacy, and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction. Lancet. 2001;358:605-613.
24. Topol EJ. Reperfusion therapy for acute myocardial infarction with fibrinolytic therapy or combination reduced fibrinolytic therapy and platelet glycoprotein IIb/IIIa inhibition: the GUSTO V randomised trial. Lancet. 2001;357:1905-1914.
25. Antman EM, Louwerenburg HW, Baars HF, et al. Enoxaparin as adjunctive antithrombin therapy for ST-elevation myocardial infarction: results of the ENTIRE-Thrombolysis in Myocardial Infarction (TIMI) 23 Trial. Circulation. 2002;105:1642-1649.
26. Effects of long-term, moderate-intensity oral anticoagulation in addition to aspirin in unstable angina. The Organization to Assess Strategies for Ischemic Syndromes (OASIS) Investigators. J Am Coll Cardiol. 2001;37:475-484.
27. Fiore LD, Ezekowitz MD, Brophy MT, et al. Department of Veterans Affairs Cooperative Studies Program Clinical Trial comparing combined warfarin and aspirin with aspirin alone in survivors of acute myocardial infarction: primary results of the CHAMP study. Circulation. 2002;105:557-563.