Progesterone induced blocking factor (PIBF) mediates progesterone induced suppression of decidual lymphocyte cytotoxicity

American Journal of Reproductive Immunology

Volumn 48, Issue 4, 2002, Pages 201-209

  Laškarin, Gordana ^a   Tokmadži, Vlatka S ^a   Štrbo, Nataša ^a   Bogovi, Tatjana ^a   Szekeres Bartho, Julia ^b   Randi, Ljiljana ^a   Podack, Eckhard R ^c   Rukavina, Daniel ^a  

^a UNIVERSITY OF RIJEKA   (Croatia)

^b UNIVERSITY OF PÉCS   (Hungary)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Decidual lymphocytes; NK cytotoxicity; Perforin; PIBF; Pregnancy; Progesterone

Indexed keywords

ANTIBODY; PERFORIN; PROGESTERONE; PROGESTERONE INDUCED BLOCKING FACTOR; PROGESTERONE INDUCED BLOCKING FACTOR ANTIBODY; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CELL ACTIVITY; CELL CULTURE; CULTURE MEDIUM; CYTOTOXIC LYMPHOCYTE; CYTOTOXICITY TEST; DECIDUA; DOSE RESPONSE; FEMALE; FIRST TRIMESTER PREGNANCY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOLOGY; MACROPHAGE; MONONUCLEAR CELL; MOTHER FETUS RELATIONSHIP; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM;

BIOLOGICAL ASSAY; DECIDUA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KILLER CELLS, NATURAL; MEMBRANE GLYCOPROTEINS; PORE FORMING CYTOTOXIC PROTEINS; PREGNANCY; PREGNANCY PROTEINS; PROGESTERONE;

EID: 0036785113     PISSN: 87558920     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0897.2002.01133.x     Document Type: Article

References (34)

1. Zuckermann FA, Head JR: Murine trophoblast resists cell-mediated lysis. Resistance to allospecific cytotoxic T lymphocytes. J Immunol 1987; 139:2856-2864.
2. Szekeres-Bartho J: Immunosuppression by Progesterone in Pregnancy. Monograph. Boca Raton: CRC Press, 1992
3. Rukavina D, Podack ER: Abundant perforin expression at the maternal-fetal interface: guarding the semialogeneic transplantant? Immunol Today 2000; 21:160-163.
4. Raghupathy R, Makhseed M, Azizieh F, Omu A, Gupta M, Farhat R: Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion. Human Reprod 2000; 15:713-718.
5. Loke YW, King A: Human Implantation. Cell Biology and Immunology. Cambridge: Cambridge University Press, 1995
6. Szekeres-Bartho J, Faust Zs, Varga P: The expression of a progesterone-induced immunomodulatory protein in pregnancy lymphocytes. Am J Reprod Immunol 1995; 34:342-348.
7. Bulmer JN, Morrison L, Longfellow M, Ritson A: Leukocytes in human decidua: investigation of surface markers and function. In Cellular and Molecular Biology of the Materno-Fetal Relationship. G Chaouat, J Mowbroy (eds). Paris, London, Colloques INSERM, John Libbey Eurotext 1991, pp. 189-196.
8. Rukavina D, Rubesa G, Gudelj L, Haller H, Podack ER: Characteristics of perforin expressing lymphocytes within the first trimester decidua of human pregnancy. Am J Reprod Immunol 1995; 33:394-404.
9. Kagi D, Lederman B, Burki K, Seiler P, Odermatt B, Olsen KJ, Podack ER, Zinkernagel RM, Hengartner H: Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin deficient mice. Nature 1994; 369:31-37.
10. Liu C-C, Walsh CM, Young JD: Perforin: structure and function. Immunol Today 1995; 16:4-25.
11. King A, Loke YW: On the nature and function of human uterine granular lymphocytes. Immunol Today 1991; 12:432-435.
12. Laskarin G, Faust Zs, Strbo N, Sotosek V, Szekeres-Bartho J, Podack ER, Rukavina D: Progesterone directly and indirectly affects perforin expression in cytolytic cells. Am J Reprod Immunol 1999; 42:312-320.
13. Sotosek V, Laskarin G, Strbo N, Dohr G, Blaschitz A, Podack ER, Rukavina D: Decidual macrophages are the population of decidual adherent cells which regulates perforin expression in the cytolytic cells. Am J Reprod Immunol 1999; 42:76-82.
14. Hameed A, Fox WM, Kurman RJ, Hruban HR, Podack ER: Perforin expression in endometrium during the menstrual cycle. Int J Gynaecol Pathol 1995; 14:143-150.
15. King A, Birkby C, Loke YW: Early human decidual cells exhibit NK activity against the K562 cell line but not against first trimester trophoblast. Cell Immunol 1989; 118:337-344.
16. King A, Gardner L, Loke YW: Evaluation of oestrogen and progesterone receptor expression in uterine mucosal lymphocytes. Hum Reprod 1996; 11:1079-1082.
17. Stewart JA, Bulmer JN, Murdoch AP: Endometrial leukocytes: expression of steroid hormone receptors. J Clin Pathol 1998; 51:121-126.
18. Szekeres-Bartho J, Csernus V, Hadnagy J, Pacsa AS: Immunosuppressive effect of serum progesterone during pregnancy depends on the progesterone binding capacity of the lymphocytes. J Reprod Immunol 1983; 5:81-88.
19. Szekeres-Bartho J, Kinsky R, Chaouat G: The effect of a progesterone-induced immunologic blocking factor on NK-mediated resorption. Am J Reprod Immunol 1990; 24:105-107.
20. Faust Z, Laskarin G, Rukavina D, Szekeres-Bartho J: Progesterone induced blocking factor inhibits degranulation of NK cells. Am J Reprod Immunol 1999; 42:71-75.
21. Szekeres-Bartho J, Faust Zs, Varga P, Szereday L, Kelemen K: The immunological pregnancy protective effect of progesterone is manifested via controlling cytokine production. Am J Reprod Immunol 1996; 35:348-351.
22. Szereday L, Varga P, Szekeres-Bartho J: Cytokine production by lymphocytes in pregnancy. Am J Reprod Immunol 1997; 38:418-422.
23. Szekeres-Bartho J, Wegmann TG: A progesterone-dependent immunomodulatory protein alters the Th1/Th2 balance. J Reprod Immunol 1996; 31:81-95.
24. Piccinni MP, Beloni L, Livi C, Maggi E, Scarselli G, Romagnani S: Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nature Med 1998; 4:1020-1024.
25. Piccinni MP, Giudizi MG, Biagiotti R, Beloni L, Giannarini L, Sampognaro S, Parronchi P, Manetti R, Anninziato F, Livi C, Romagnani S, Maggi E: Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established th1 cell clones. J Immunol 1995; 155:128-133.
26. Chaouat G, Cayol V, Mairovitz V, Dubanchet S: Localization of the Th2 cytokines IL-3, IL-4, IL-10 at the fetomaternal interface during human and murine pregnancy and lack of requirement for Fas/Fas ligand interaction for a successful allogeneic pregnancy. Am J Reprod Immunol 1999; 42:1-13.
27. Strbo N, Laskarin G, Sotosek V, Vlastelic I, Podack ER, Rukavina D: The significance of IL-15 in regulation of perforin in the first trimester pregnancy decidual lymphocytes. Period Biol 1998; 100:64.
28. Mrozek E, Anderson P, Caligiuri MA: Role of interleukin-15 in the development of human CD56+ natural killer cells from CD34+ hematopoietic progenitor cells. Blood 1995; 87:2632-2640.
29. Ye W, Zheng LM, Young JD, Liu CC: The involvement of interleukin (IL) -15 in regulating the differentiation of granulated metrial gland cells in mouse pregnant uterus. J Exp Med 1996; 184:2405-2410.
30. Carson WE, Fehniger TA, Haldar S, Echert K, Lindermann MJ, Lai CF, Croce CM, Baumann H, Caligiuri MA: A potential role for interleukin-15 in the regulation of human natural killer cell survival. J Clin Invest 1997; 99:937-943.
31. Verma S, Hiby SE, Loke YW, King A: Human decidual natural killer cells express the receptor for and respond to the cytokine interleukin 15. Biol Reprod 2000; 62:959-968.
32. Puzanov IJ, Benett M, Kumar V: IL-15 can substitute for the marrow microenviroment in the differentiation of natural killer cells. J Immunol 1996; 157:4282-4285.
33. Kitaya K, Yasuda J, Yagi J, Tada Y, Fushiki S, Honjo H: IL-15 expression at human endometrium and decidua. Biol Reprod 2000; 63:683-687.
34. Anderson DM, Kumaki S, Ahdieh M, Bertle J, Tometsko M, Loomis A, Giri J, Copeland NG, Gilbert DJ, Jenkins NA: Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J Biol Chem 1995; 270:29862-29869.